Structure of PDB 8ia0 Chain Lc Binding Site BS01

Receptor Information
>8ia0 Chain Lc (length=98) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAQSIGAKLALVIKSGKVVLGYRSTLKALRSGKAKLILIAANTPPLRKSE
LEYYSMMSKTPVHHYSGTNIELGTACGKLFRCSTMAILDAGDSDILAD
Ligand information
>8ia0 Chain C1 (length=2928) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagc
uucggcgcaucaucgaccgauccugauguauucggauggauuugaguagg
agcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggug
aagccagaggaaacucugguggaggcucgcugacgugcaagaucgucaaa
ucugagcaugggggcgaaagacuaaccaucuaguagcugguuaccgccga
aguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcg
aaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggu
cgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaug
cgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucaga
caccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaa
gucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuag
cccugaaaauggauggcgcucaagcgucccacccauaccccgcccucagg
guagaaacgaugcccugaggaguaggcggccguggaggucagugacgaag
ccuagggcgugagcccgggucgaacggccucuagugcagaucuugguggu
aguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguu
ccaugugaacagcgguuggacauggguuagucgauccuaagccauaggga
aguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccg
guuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaa
cgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaac
ggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccgg
aagagcccgacacuucugucggguccggugcgcucucgacgucccuugaa
aauccgcgggagggaauaauucucacgccaggucguacucauaaccgcag
cagguccccaaggugaacagccucugguugauagaacaauguagauaagg
gaagucggcauccguaacuucgggaaaagggcucuaaggguugggcacgu
ugggcuuugggcggacgcccugggagcagagggccucuagccgggcaacc
ggccggcggcccucagcacccgggguugaagcccuuagcccggcgugcgg
uuaacaaccaacuuagaacugguacggacagggaaucugacgucuauagc
auugcgauggccagaaagugguguugacgcaaugugucugcccagugcuc
ugaaugucaaagugaagaaauucaaccaagcgcggguaaaaugccucguc
aucuaauuagugacgcgcauggauaacgagauucccacugucccuaucua
cuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggg
gaagacccuguugagcuugacucuaguuugacauugugaaaagacauagg
agguguagaauaggugggagcuucggcgccagugaaauaccacuacuccu
auuguuuuuuuacuuauucaaugugaagacauugucagguggggaguucc
uuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggaua
acuggcuuguggcggccaagcguagcgacgucgcuucggcucuuccuauc
auaccgaagcagaauucgguaagcguuggauuguucacccacuaauaggg
aaagcuggggaccgucgugagacagguuagucccuacugaugaacucguc
gcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauug
guuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcugg
auaauggcugaacgccucuaagucagaauccaugccagaacgcgacgaua
cuacccgcacguuguagacguauaagaauaggcuccggccucguauccua
gcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguau
ugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugu
gcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcug
aggguaagcccuccuucgccuagauuuc
........................<<<<<<.....<<....>>......>
>>>>.>.........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<<......
>>>>>>..>>>..................................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<
<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.....<.<<<<<<<<......<<<<<<..>>>>>>.......>>>
>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<....<<<
<<<<<.<<<<..<<<...<<<<.....>>>>...>>>....<<<<<..<<
....>>...>>>>>.<<<<<<<<..............>>>.>>>.>>...
.>>>>.>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<.
..<<<<<<<....>>>>>>>....>>>>..<<<<<........>>>>>..
>>>>>>>>>..<<.<....>.>>.>>>>>>......>.>>...<<<<<..
..<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<..
......>>.>.....>>>>>....<<<.<<<<.<......>>>>>.>>>.
..>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....
<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<.
.........<<<.<<<<<<<<<<.......<<<<<.<<<...<<......
...>>...>>>.........<<......>>...>>>>>...>>>>>>>>>
>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<
<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<
<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.
....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...
<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<.
...>>>........<<<<<......>>>>>....>>>....>>...<<<<
<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......
<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<...((..>>>>.><...<
<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.
...><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.......
..>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<....
..>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<
.......<..<<<<<<.<.<<.................<<<<<.<<<<<.
.<.<<<..<<<<....<<<<<<<<.<<.<<<<<<<.<<.<<<<<....>>
>>>.>>.>>>>>>>.>>.>>>>>>>>....>>>>..>>>>...>>>>>..
....>>>>>......>>...>.>>>>>>..<<<<<<<<<..<<<<...<<
<<<<<....<<<<.....>>>>......>>>>>>>...<<<<<.<<<<<.
<<<<<.<<........>>.>>>>>....>>>>>>>>>>..<<<<..<<<<
<<.......>>>>>>.>>>>>>>>..>>.>>>>>>>.>...>>.>>>>>>
>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<
<....<<<<<<.<<<<<<.<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<
<<..........<<<<<..<<....>>............>>>>>.>>>>>
>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>>..>>>>>.<<
<<<<<..<<<<<.....>>>>>>>>>>>>....>>>>>.>.>>>>>>...
..........<<<<<<...<<...>>...>>>>>><<<<<<.<<<<<..<
.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>
>.>>>>>>.<<<<<<<....>>>.>>>>....>>>.>>>>>....<<<<<
<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<
<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..>>>>>.<<<
<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>..
...<<<<<.<<.<<<......<<.......<<<....>>>....>>....
....<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>....
..........>>>>>.>>>>>...<<<<<<<.............>>....
<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>..
.>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ia0 Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Resolution2.7 Å
Binding residue
(original residue number in PDB)
L28 G29 Y30 R31 S32 K35 P52 R55 F88 R89 C90 S91
Binding residue
(residue number reindexed from 1)
L20 G21 Y22 R23 S24 K27 P44 R47 F80 R81 C82 S83
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function

View graph for
Cellular Component
External links
PDB RCSB:8ia0, PDBe:8ia0, PDBj:8ia0
PDBsum8ia0
PubMed37129998
UniProtG0SEI0

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