Structure of PDB 4v3p Chain Lc Binding Site BS01

Receptor Information

>4v3p Chain Lc (length=124) Species: 4565 (Triticum aestivum)

MSSGKVKAGELWNKSKDDLTKQLAELKTELGQLRIQKVASSGSKLNRIHD
IRKSIARVLTVINAKQRAQLRLFYKNKKYAPLDLRAKQTRAIRRRLSPDE
KSRVLEKTKKRTVHFPQRKFAIKA

Ligand information

>4v3p Chain L1 (length=3352)

gcgcgaccccaggucaggcgggacuaccgcugaguuuaagcauauaaaua
agcggaggagaagaaacuuacaaggauuccccuaguaacggcgagcgaac
cgggagcagcccaagaaucgggcggcugugccguccgaauuguagucugg
agaggcguccucagcgacggaccgggcccaaguccccuggaaaggggcgc
cugggagggugagagccccguccggcccggacccugucgccccacgaggc
gccgucaacgagucggguuguuugggaaugcagcccaaaucgggcgguag
acuccguccaaggcuaaauacaggcgagagaccgauagcgaacaaguacc
gcgagggaaagaugaaaaggacuuugaaaagagagucaaagagugcuuga
aauugccgggagggaagcggaugggggccggcgaugcgccccggccguau
gcggaacggcucuugcugguccgccgcucggcucggggcguggacuguug
ucggccgcgccggcggccaaagcccgggggcuccgcgcccccggcagccg
ucgucggcacggccgguacccgcgcgccgaaaggcgugccccucggggca
cugcgcugcaacgcccugcgggcuccccauccgacccgucuugaaacacg
gaccaaggagucugacaugcgugcgagucgacggguucugaaaccuggga
ugcgcaaggaagcugacgagcgggaggcccucacgggccgcaccgcuggc
cgacccugaucuucugugaaggguucgaguuggagcacgccugucgggac
ccgaaagauggugaacuaugccugagcggggcgaagccagaggaaacucu
gguggaggcucgaagcgauacugacgugcaaaucguucgucugacuuggg
uauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaa
guuucccucaggauagcuggagcccauuacgaguucuaucagguaaagcc
aaugauuagaggcauuggggacgcaacguccucgaccuauucucaaacuu
uaaauagguaggauggcgcggcugcuucggugagccgugccauggaaucg
ggugcuccaagugggccauuuuugguaagcagaacuggcgaugcgggaug
aaccggaagccggguuacggugcccaacugcgcgcuaaccuagaacccac
aaaggguguuggucgauuaagacagcaggacgguggucauggaagucgaa
auccgcuaaggaguguguaacaacucaccugccgaaucaacuagccccga
aaauggauggcgcugaagcgcgcgacccacacccggccaucugggcgagu
gccaugccccgaugaguaggagggcgcggcggccaugcaaaacccgggcg
cgagcccgggcggagcggccgucggugcagaucuuggugguaguagcaaa
uauucaaaugagaacuuugaaggccgaagaggagaaagguuccaugugaa
cggcacuugcacauggguaagccgauccuaagggaagggguaaccccggc
agauagcgcgaucacgcgcauccccgaaagggaaucggguuaagauuccc
gagccggguguggcgguugacggcgacguuaggaaguccggagacgccgg
cgggggccucgggaagaguuaucuuuucugcuuaacggccugccaacccu
ggaaacgguucagccggagguagguccaguggccggaagagcacacgucg
cgcgguguccggugcgcccccggcggcccaugaaaauccggaggaccgag
uaccgucacgcccggucguacucauaaccgcaucaggucuccaaggugaa
cagccucuggccaauggaacaauguaggcaagggaagucggcaaaacgga
uccguaacuucgggaaaaggauuggcucugaggacugggcucgggggucc
cggccccgaacccgucggcugucggcggauugcucgagcugcucacgcgg
cgagagcgggucgccgcgugccggccgggggacggaccgggaaucgcccc
uucgggggcuuuccccgagcaugaaacagucgacucagaacugguacgga
caaggggaauccgacuguuuaauuaaaacaaagcauugcgaugguccucg
cggaugcugacgcaaugugauuucugcccagugcucugaaugucaaagug
aagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucu
uaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaugaau
uaacgagauucccacugucccugucuacuauccagcgaaaccacagccaa
gggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuug
acucuaguccgacuuugugaaaugacuugagagguguaggauaaguggga
gcccucacgggcgcaagugaaauaccacuacuuuuaacguuauuuuacuu
auuccgugggucggaagcggggcaugccccaaggcccggucuuaccgggc
cgauccgggcggaagacauugucagguggggaguuuggcuggggcggcca
aucuguuaaaagauaacgcagguguccuaagaugagcucaacgagaacag
aaaucucguguggaacaaaaggguaaaagcucguuugauucugauuucca
guacgaauacgaaccgugaaagcguggccuaucgauccuuuagacuucgg
aguuugaagcuagaggugucagaaaaguuaccacagggauuacuggcuug
uggcagccaagcguucauagcgacguugcuuuuugauccuucgaugucgg
cucuuccuaucauugcgaagcagaauucaccaaguguuggauuguucacc
caccaauagggaacgugagcuggguuuagaccgucgugagacagguuagu
uuuacccuacugaugacagugucgcgauaguaauucaaccuaguacgaga
ggaaccguugauucacacaauuggucaucgcgcugguugaaaagccagug
gcgcgaagcuaccgugugccggauuaugacugaacgccucuaagucagaa
uccaagcuagcaugcgacgccugcgcccgccgcccgccccgacccacguu
aggggcgcuugcgcccccaagggcccgugccauuggcuaagccgguccgg
ccgaagugccgcggucggccgccucgaagcucccuucccaacgggcggug
ggcuaauccuuugcagacgacuuaaauacgcgacggggauuguaaguggc
agaguggccuugcugccacgauccacugagaucccgcgucgcacggauuc
gu

...........................<<<<.....<......>......
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.<<<<<<.<<<<.<<<<<<<.<<<<<<<.....<<<<......>>>>.((
......<<<.....))>>>....>>>>>>>...>>>>>>>.....>>>>>
>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..[[
....>>>>>..>>>................................<.<<
....>>...>...........<<<<....>>>>.................
...................<<<<<<<<<<.<<...<<<<<<<<<<<<..<
<<<<<.<<<<....>>>>.>>>>.>>..>>>>.>>>>>>>>....<<<<<
<<<<<<<.<<<<<<<<.......<<<<<<<<.....>>>>>>>>......
>>>>>>>>.>>>>>>>.....<<<<<<<....>>><<<<<<....>>>>>
>.>>>>..>>>>>....>>.>>>.>>>>>>>....<<<<........>>>
><<<<<<.....<<<<<.<<<<<<..<<...<<<<<<....>>>>>>...
.>>...<<....>>....<<<<<<.<<<<<....>>>>>.>.>>>>>...
<<<<<<<...<....>...>>>>>.>>.......>>>>>>.>>>>>...<
<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>
>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>
>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<...
.<.<<<....>>>.><.<<<<<<......<<...<<<<<<...<<<<<..
...<...<.<<<..(<<<<<<......)>>>>>>.>>>.>...>...>>>
>>....>>>>>>..<<<<<<<<<<<....>>.>>>>>>>>>.......>>
...>>>>>>..>..<<<<.<<<<<.....>>>>>.>>>>....<<<....
..>>>...<<<<<<<...<<<(((.....<<<<<<...............
...<<<.<<<<<<.<<<.......<<<<<.<<....<<.........>>.
...>>.........<<......>>...>>>>>...>>>.>>>>>>>>>..
........)))...{..>>>>>>.>>>...>>>>>>><<<<.<<<<<...
....>>>>>.>>>>....>>>>>>..<<<<<<<<........<<<<<<<.
...>>>>>>>......>>>>>>>>........>>>>>><<.....<<...
..<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...
<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>...
.....<<<<<....>>>>>...>>>....>>>..<<<<<........>>>
>>))<<<<<<<<<.<<<..<<<....>>>...<...<<<<<<...<<<<.
<<<.<<..<<<...<<<<.......>>>>..<.....<..........<<
.....<<<<...>>>>......>>.........>......>.<<.<<...
..>>>>...>>>.....>>>>>.>>>>.........>>>>>>...>....
.>>>.>>>>>>>>>.>>>..>>.....<<......>>>>>>>..<<<...
..>>>...>>>>..<<<<.....<<<<<<<.<<...............<<
<<<.....<..>......>>>>><<.<<<<<<<<<<<.<<<<<<<<<<<<
<<<..<<<..<<<<<<<<<<<.<<<<<<.<<<<<<..<<<<<....>>>>
>..>>>>>>.>>>>>>>>.>>>>>>..>>>..>>>.>>>>>>...<<<<<
....>>>>>..>>>>>>>>>......>>>>>..>>>>>>.>>........
....<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<...
.>>>.......>>>>>>>...<<<.<<<..<<<<<<....<<<.....<<
<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>.
.......<...........<<<<<.......>>>>>.....>....>>>.
...>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<
<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..
<<<<<.<<<.<<<...<<<<<<<<<.<<<<<<<...........<<<<..
<<<......>>>............>>>>..>>>>>>>..>>>>>>>>>..
.<<<<<....<<<<<...<<<<....>>>>..<<<<<<<<...>>>>>>>
>..>>>>.>>>>>>......>>>.>>>..>>>>>...<<<.....>>>..
<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<....
...>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<...
....>>>>..>>>.<<<....>>>.>>))).......<<<<<<.<<<<..
..]].>>>>>>>>>>..........>>>>..>>>>>>.......<<.<..
.<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<
<..<<<<<..<<<.<.<<<......>>>.>...>>>.<<<.........>
>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>...
.>>..>>>.>>>>>....<<<<<<...<<<<.<.<<<<<...........
......>>>>>.><<<<<....<<<...<<<<<<<<<......>>>>...
>>>>>..>>>...>>>>>..<<<...<<<<<...........>>>>>...
>>>..>>>>.....>>>>>>.....<<<<<<<<<<<....<<.<<....}
..<<<<<....>>>>>....>>..<<<.((...>>>....<<<<<<<<<<
<......>>>>.>>>>>>>.))......<...>..>>....>>>>>>>>>
>>..<<<<.<.............>.....<<<<<<<<..<<....<<<<.
...<<<<<......>>>>>...>>>>...>>..>>.>>>>>>...>>>>.
..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v3p The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes.
• Resolution: 34.0 Å
• Binding residue (original residue number in PDB): R94 R95 D99 R103 K109 R111 R118 F120
• Binding residue (residue number reindexed from 1): R94 R95 D99 R103 K109 R111 R118 F120

Gene Ontology

Molecular Function

• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v3p, PDBe:4v3p, PDBj:4v3p
• PDBsum: 4v3p
• PubMed: 25376914
• UniProt: Q8L805|RL35_WHEAT Large ribosomal subunit protein uL29 (Gene Name=RPL35)