Structure of PDB 8rxh Chain Lb Binding Site BS01

Receptor Information
>8rxh Chain Lb (length=68) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKSKNHTNHNQSSKNHRNGIKGPVPLHLHNSKRGSWLPALVNARRVRKHN
QKAALKKRRERIAAFAAK
Ligand information
>8rxh Chain L1 (length=1677) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacucag
cggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaaga
gggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggc
acaaauaucauugugugguuggugcaggaguggcgaaauucaagcgaaaa
gcaaacccguugcugaauacaacccuucaugugaguauugagccaaagaa
gguguuagcccauugagccauaaaccugagcgccucaugaauaagcgagu
agcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaa
guuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaa
guuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugac
aaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugc
auuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaucu
ugggucuuggugaaaugagcggaguauuugagcugcgcacggcgcgccgc
acgcacugguuucuucuccgugaugcuccauguuggcgauggaaaugggg
ugcccccacccgucuugaaacacggaccaaggagucaaacagacgcgcaa
gggaggagauaugguugccaguacuucucucguacugaaagggagaugca
aaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacac
cgaccggcccuccguggguugcguuggagugugccuguuuggacccgaaa
gguggugaacuaugccugaacaaggugaagcccggggaaacccaggugga
ggccuguagcgaugcugacgugcaaaucgcucguaugauuuggguaucgg
agcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucc
cucaggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauu
agaggucgaccuauucucaaacuuuaaaugugcaaacaaaccgugccuua
gccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuu
cuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggauaugug
gcgucaaaacuuaugggcucauucucgauacgugaaaaggguguuggugg
auacaguuggacccaaccgaauccaccggccccgaaaauggaugacgcuu
aagcccaauuagugauugcccauuauuccuuugguaagggcggaaacaaa
uggagaaaguguagcccuuccgauguagauguggccuggagguuaggacg
aagcuuauggcgugagccuaagauggaccggccucuagugcagaucuugg
uuggcguagcaaagaucuaacggagauauacucaacaugcaacguuggau
acuggagcggggaaggauuucgugccaacggcacucguacacgaguuguu
cggaaacugagcacaacguuauaucguuuuguuaggaaagugaaggugug
ucggcggagcuguucgacugugaaaaggggcaacagagaaccugggauua
uauuccaaaaagaaauugcauguggga
.......................<<<<<......<......>.......>
>>>.>.........<<....>>..<<<<<<......<<.....>>....>
>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>
>............<<<<...<<<<<<<<.<<<<<......<<<......<
<<<.......>>>>.....<<........>>......>>>.<<.......
((.....>>)).....>>>>>...>>>..>>>>>.>>>>...........
.<<<<<<<........>>>>>>>......<<<<<........>>>>>..>
>>....................................<<....>>....
............<<<<....>>>>..........................
........<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<
<<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>........
.>>>>..>>>>........<<<<<.....<<<<<..<<.<<<<..>>>>.
..>>...>>>.>>..>>>>>.....<<<<...>>>>>>....>>>>>>>>
>>>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..
<<<..<<<.<............>>>>..>>>...<<....>>..<<<<<.
....>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>
><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<..<
<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>...
..>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...
<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<
....>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<<..
..<<<....>>>....>>>..>.>>...>>>>>>>.....<<<.<<<<<.
<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.
<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<
<<(((......<..<<<<........<...........<<<.<<<<<<<<
<<..................>>>>>>>>>>>>>..........))).>..
..>>>>.>.........>>>...>>>>>>><<<<.<<<<<..........
.>>>>.........>>>>>>>>>....>>>>>....<<<<<<<<......
...<<<..<<<....>>>.>>>.......>>>>>>>>........>>>>>
>..............<<<<<<<....................>>>>>>>.
...................<<<<<....<<.....>>..>>>>>....<<
..........<<.<<<<<......>>>>............<..<.<..<<
.....<...>....>>..>.>..>...>.>>..........<<<<.....
....>>....>>.>>............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		K5 N6 H7 T8 N9 H10 N11 Q12 S13 K15 H17 R18 N19 P26 H28 L29 H30 N31 S32 K33 R34 L38 N43 R45 R46 V47 R48 K49 H50 N51 Q52 R60 R62
Binding residue
(residue number reindexed from 1)		K4 N5 H6 T7 N8 H9 N10 Q11 S12 K14 H16 R17 N18 P25 H27 L28 H29 N30 S31 K32 R33 L37 N42 R44 R45 V46 R47 K48 H49 N50 Q51 R59 R61
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum8rxh
PubMed38722744
UniProtQ4Q178

[Back to BioLiP]