Structure of PDB 8rxx Chain La Binding Site BS01

Receptor Information
>8rxx Chain La (length=125) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHHMKIKDLREKSKDDLLKTLTEYKKELSQLRVVQQTGGAETRLGRIRPI
RKSIARILTVLNQNERSNLKMFYADRKLRCKTPKVLRTKLTHRRRLALKE
NEKNRKTSRQMRQAHKFPKRVYAVK
Ligand information
>8rxx Chain L1 (length=1657) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucauugugugguuggugcaggaguggcgaaauucaagcgaaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacaagcgagua
gcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaag
uuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaag
uuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugaca
aagacaauggaaguaccuccauuucaacggccagaaccagcccuacugca
uuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaucuu
gggucuuggugaaaugagcggaguauuugagcugcgcacggcggccgcac
gcacugguuucuucuccgugaugcuccauguuggcgauggaaauggggug
cccccacccgucuugaaacacggaccaaggagucaaacagacgcgcaagg
gaggagauaugguugccaguacuucucucguacugaaagggagaugcaaa
augcaucuguggugugcacacgucaaauccguuugauuugcccaacaccg
accggcccuccguggguugcguuggagugugccuguuuggacccgaaagg
uggugaacuaugccugaacaaggugaagcccggggaaacccagguggagg
ccuguagcgaugcugacgugcaaaucgcucguaugauuuggguaucggag
cgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucccu
caggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauuag
agggaccuauucucaaacuuuaaaugugcaaacaaaccgugccuuagcca
acugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuuc
gguaagcggagcaggcgaugcggaaugaaccgcuuagggauauguggcgu
caaaacuuaugggcucauucucgauacgugaaaaggguguugguggauaa
auccaccggccccgaaaauggaugacgcuuaagcccaauuagugauugcc
cauuauuccuuugguaagggcggaaacaaauggagaaaguguagcccuuc
cgauguagauguggccuggagguuaggacgaagcuuauggcgugagccua
agauggaccggccucuagugcagaucuugguuggcguagcaaagaucuaa
cggagauauacucaacaugcaacguuggauacuggagcggggaaggauuu
cgugccaacggcacucguacacgaguuguucggaaacugagcacaacguu
auaucguuuuguuaggaaagugaaggugugucggcggagcuguucgacug
ugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugca
uguggga
......................<<<<<......<......>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
............<<<<...<<<<<<<<.<<<<<......<<<......<<
<<.......>>>>.....<<........>>......>>>.<<.......(
(.....>>)).....>>>>>...>>>..>>>>>.>>>>............
<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>
>....................................<<....>>.....
...........<<<<....>>>>...........................
.......<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<
<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>.........
>>>>..>>>>........<<<<<.....<<<<<<.<<.<<<<.>>>>...
>>.>.>>>.>>..>>>>>.....<<<<...>>>>>>....>>>>>>>>>>
>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..<<
<..<<<.<............>>>>..>>>...<<....>>..<<<<<...
..>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><
<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<...<<
<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....
>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<
.......>>......>>>>>>......>.>>...<<<<<....<.<<<..
..>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<...<.
<<<..>>>.>...>>..>>.>...>>>>>>>.....<<<.<<<<<.<<..
...>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<
<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<((
(......<..<<<<........<...........<<<.<<<<<<<<<<..
>>>>>>>>>>>>>..........))).>....>>>>.>.........>>>
...>>>>>>><<<<.<<<<<...........>>>>.........>>>>>>
>>>....>>>>>....<<<<<<<<.........<<<..<<<....>>>.>
>>.......>>>>>>>>........>>>>>>..............<<<<<
<<....................>>>>>>>....................<
<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<..
....>>>>............<.......<<...<......>...>>....
.>.....>.>>..........<<<<.........>>....>>.>>.....
.......
Receptor-Ligand Complex Structure
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PDB8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		R77 K78 R80 K82 H93 R94 L97 N102 N105 R106 K107 S109 M112 R113 H116 K117 K120 R121
Binding residue
(residue number reindexed from 1)		R76 K77 R79 K81 H92 R93 L96 N101 N104 R105 K106 S108 M111 R112 H115 K116 K119 R120
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
PDBsum8rxx
PubMed38722744
UniProtQ4Q8V7

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