Structure of PDB 6sxo Chain LY Binding Site BS01

Receptor Information
>6sxo Chain LY (length=134) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKFNPFVTSDRSKNRKRHFNAPSHIRRKIMSSPLSKELRQKYNVRSMPIR
KDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIH
PSKVVITRLKLDKDRKKILERKAKSRQVGKEKGK
Ligand information
>6sxo Chain L5 (length=268) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaaaagaacuuugaagagagaguucaagagggcguucaaacgagaacu
uugaaucggguucagauccccgaaucuuggaaagcgucgcgguuccggcg
gcguaagggcugggucggucgggcuggggcgcgaagcggggcugggcgcg
cgccgcggcuggacgaggcggcgacucuggacgcgagccgggcccuuccc
guggaucgccccagcugcggcgggcgucgcgcggcgccucgccucggccg
gcgccuagcagccgacuu
..........<<<......>>>..............<<<<<<.......>
>>>>><<<<<........>>>>>..........<<<<<<<.......>>>
>>>><<<<<<<<..<<<<<<<.<<<<<<<<<....<<<<<...<<<<.<<
.<<<<<<.<<<<<............>>>>>.>>>>.>>>>.>>>>..>>>
>>....>>>>>>>>>...<<<<<<<.<<<..>>>.>>>>.>>>.>>>>>>
>.......>>>>>..>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6sxo MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R87 K89 A90 N91
Binding residue
(residue number reindexed from 1)		R87 K89 A90 N91
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0048027 mRNA 5'-UTR binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0034644 cellular response to UV
GO:0042273 ribosomal large subunit biogenesis
GO:0045727 positive regulation of translation
GO:0071479 cellular response to ionizing radiation
GO:0071480 cellular response to gamma radiation
GO:1902164 positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1904803 regulation of translation involved in cellular response to UV
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sxo, PDBe:6sxo, PDBj:6sxo
PDBsum6sxo
PubMed32034140
UniProtP61254|RL26_HUMAN Large ribosomal subunit protein uL24 (Gene Name=RPL26)

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