Structure of PDB 8i9x Chain LX Binding Site BS01

Receptor Information
>8i9x Chain LX (length=137) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKAAKGAQAKKAAQAALKGVHSSTTFHRPKTLVLSRAPKYPRKSIPHEPR
LDEHKIIIHPLNTEGALKKIEEQNTLVFIVDVKANKAQIKQALKKLYDID
TVKINTLIRPDGTKKAFARLTPDVDALDIAATKLGLV
Ligand information
>8i9x Chain C1 (length=2658) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagc
uucggcgcaucaucgaccgauccugauguauucggauggauuugaguagg
agcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggug
aagccagaggaaacucugguggaggcucgcugacgugcaagaucgucaaa
ucugagcaugggggcgaaagacuaaccaucuaguagcugguuaccgccga
aguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcg
aaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggc
auucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcg
augcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucauc
agacaccacaaaaggcguuaguacaucuugacagcaggacgguggccaug
gaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguac
uagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccuc
aggguagaaacgaugcccugaggaguaggcggccguggaggucagugacg
aagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggu
gguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaag
guuccaugugaacagcgguuggacauggguuagucgauccuaagccauag
ggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaag
ccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacu
gaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuu
aacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggc
cggaagagcccgacacuucugucggguccggugcgcucucgacgucccuu
gaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccg
cagcagguccccaaggugaacagccucugguugauagaacaauguagaua
agggaagucggcuccguaacuugguacggacaggggaaucugcgagauuc
ccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcu
uggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuug
acauugugaaaagacauaggagguguagaauaggugggagcuucggcgcc
agugaaauaccacuacuccuauuguuuuuuuacuuauucaaugugaagac
auugucagguggggaguuccuuuagucccucgaaauuugaggcuagagga
gaaaaguuaccacagggauaacuggcuuguggcggccaagcguagcgacg
ucgcuuuuuggaugcggcucuuccuaucauaccgaagcagaauucgguaa
gcguuggauuguucacccacuaauagggaacgugagcuggaccgucguga
gacagguuagucccuacugaugaacucgucgcaaugguaauucagcuuag
uacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgacc
gggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucua
agucagaauccaugccagaacgcgacgauacuacccgcacguuguagacg
uauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccgg
ccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgg
gaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagca
guagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgcc
uagauuuc
........................<<<<<<.....<<....>>......>
>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<<......
>>>>>>..>>>....>.............................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<
<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>
>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<
<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>....<<<<<..<<
....>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>...
.>>>>.>>>>>>>>>.<<.<..<<<<<<<...<.<<<<<<<<<..<<<<.
..<<<<<<<....>>>>>>>...>.>>>..<<<<<........>>>>>..
>>>>>>>>>>.<<.<....>.>>.>>>>>>>.....>.>>...<<<<<..
..<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<..
......>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>
.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>.
...<<<......>>>...<<<<<<<...<<<((......<<<<<<.....
.<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<...
......>>...>>>.........<<......>>...>>>>>...>>>>>>
>>>>>>>...........)).>....>>>>>>.>>>...>>>>>>><<<<
<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<....
..<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>>
<<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<
...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<
<<....>>>........<<<<<......>>>>>....>>>....>>...<
<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>....
...<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<...((..>>>>.><.
..<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>
>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>....
.....>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<.
.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<.
<<<<<<<<....<<<<<<.<..>.>>>>>>...<<<<<<<<<>>.>>>>>
>>>>>.>>>>>>>>>>>..>>>>>>....>>....<<<<<........>>
>>>....<<<<<..<<<........<<<<<<.<<<<<<.<<<<<.<<<<<
<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>...
.........>>>>>.>>>>>>>.>>>>>>>>>>...<<<<...>>>>...
..>>>>>>>>..>>>>>.<<<<<<<..<<<<<<...>>>>>>>>>>>>>.
...>>>>>.>.>>>>>>.............<<<<<<...<<...>>...>
>>>>>.....((...<<<<<<<<<<..<.<<<<<<<......>>>>>>>.
..>.<<<.....))..>>>.....>>>>>....>>>>>.<<<<<<<....
>>>.>>>>....>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<....
.............>>>>>.><<<<<...<<<<....<<<<<<<<<<))..
>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........
>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<.....
.<<.......<<<<..>>>>....>>........<<<<.....<<<.<<<
<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>
>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<
<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>.
..>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8i9x Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		F45 H46 R47 T50 L53 R55 A56 P57 K58 Y59 R61 T82 E83 K88 Q92 N104 K105 K122 N124 T125 L126 I127 P129 K133 K134 F136 R138
Binding residue
(residue number reindexed from 1)		F26 H27 R28 T31 L34 R36 A37 P38 K39 Y40 R42 T63 E64 K69 Q73 N85 K86 K103 N105 T106 L107 I108 P110 K114 K115 F117 R119
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8i9x, PDBe:8i9x, PDBj:8i9x
PDBsum8i9x
PubMed37129998
UniProtG0S507

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