Structure of PDB 8rxh Chain LW Binding Site BS01

Receptor Information
>8rxh Chain LW (length=121) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASIKCGSRRKARRAHFQAPSHVRRVLMSAPLSKELRAKYNVRAMPVRKDD
EVIVKRGTFKGREGKVTACYRLKWVILIDKVNREKANGSTVAVGIHPSNV
EITKLKLTHHRKSILERKDRS
Ligand information
>8rxh Chain L1 (length=1677) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacucag
cggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaaga
gggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggc
acaaauaucauugugugguuggugcaggaguggcgaaauucaagcgaaaa
gcaaacccguugcugaauacaacccuucaugugaguauugagccaaagaa
gguguuagcccauugagccauaaaccugagcgccucaugaauaagcgagu
agcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaa
guuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaa
guuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugac
aaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugc
auuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaucu
ugggucuuggugaaaugagcggaguauuugagcugcgcacggcgcgccgc
acgcacugguuucuucuccgugaugcuccauguuggcgauggaaaugggg
ugcccccacccgucuugaaacacggaccaaggagucaaacagacgcgcaa
gggaggagauaugguugccaguacuucucucguacugaaagggagaugca
aaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacac
cgaccggcccuccguggguugcguuggagugugccuguuuggacccgaaa
gguggugaacuaugccugaacaaggugaagcccggggaaacccaggugga
ggccuguagcgaugcugacgugcaaaucgcucguaugauuuggguaucgg
agcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucc
cucaggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauu
agaggucgaccuauucucaaacuuuaaaugugcaaacaaaccgugccuua
gccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuu
cuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggauaugug
gcgucaaaacuuaugggcucauucucgauacgugaaaaggguguuggugg
auacaguuggacccaaccgaauccaccggccccgaaaauggaugacgcuu
aagcccaauuagugauugcccauuauuccuuugguaagggcggaaacaaa
uggagaaaguguagcccuuccgauguagauguggccuggagguuaggacg
aagcuuauggcgugagccuaagauggaccggccucuagugcagaucuugg
uuggcguagcaaagaucuaacggagauauacucaacaugcaacguuggau
acuggagcggggaaggauuucgugccaacggcacucguacacgaguuguu
cggaaacugagcacaacguuauaucguuuuguuaggaaagugaaggugug
ucggcggagcuguucgacugugaaaaggggcaacagagaaccugggauua
uauuccaaaaagaaauugcauguggga
.......................<<<<<......<......>.......>
>>>.>.........<<....>>..<<<<<<......<<.....>>....>
>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>
>............<<<<...<<<<<<<<.<<<<<......<<<......<
<<<.......>>>>.....<<........>>......>>>.<<.......
((.....>>)).....>>>>>...>>>..>>>>>.>>>>...........
.<<<<<<<........>>>>>>>......<<<<<........>>>>>..>
>>....................................<<....>>....
............<<<<....>>>>..........................
........<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<
<<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>........
.>>>>..>>>>........<<<<<.....<<<<<..<<.<<<<..>>>>.
..>>...>>>.>>..>>>>>.....<<<<...>>>>>>....>>>>>>>>
>>>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..
<<<..<<<.<............>>>>..>>>...<<....>>..<<<<<.
....>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>
><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<..<
<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>...
..>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...
<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<
....>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<<..
..<<<....>>>....>>>..>.>>...>>>>>>>.....<<<.<<<<<.
<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.
<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<
<<(((......<..<<<<........<...........<<<.<<<<<<<<
<<..................>>>>>>>>>>>>>..........))).>..
..>>>>.>.........>>>...>>>>>>><<<<.<<<<<..........
.>>>>.........>>>>>>>>>....>>>>>....<<<<<<<<......
...<<<..<<<....>>>.>>>.......>>>>>>>>........>>>>>
>..............<<<<<<<....................>>>>>>>.
...................<<<<<....<<.....>>..>>>>>....<<
..........<<.<<<<<......>>>>............<..<.<..<<
.....<...>....>>..>.>..>...>.>>..........<<<<.....
....>>....>>.>>............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		A2 S3 K5 C6 G7 R9 K11 A12 R13 H16 V26 L27 S29 P31 R43 R57 G58 T59 R84 K86 A87 N88 H97 S99 N100 R118 K119 R121
Binding residue
(residue number reindexed from 1)		A1 S2 K4 C5 G6 R8 K10 A11 R12 H15 V25 L26 S28 P30 R42 R56 G57 T58 R83 K85 A86 N87 H96 S98 N99 R117 K118 R120
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:0031981 nuclear lumen
GO:0097014 ciliary plasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum8rxh
PubMed38722744
UniProtQ4QAC5

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