Structure of PDB 8g5y Chain LW Binding Site BS01

Receptor Information
>8g5y Chain LW (length=118) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKVELCSFSGYKIYPGHGRRYARTDGKVFQFLNAKCESAFLSKRNPRQIN
WTVLYRRKHKKGQSRTRRAVKFQRAITGASLADIMAKRNQKPEVRKAQRE
QAIRAAKEAKKAKQASKK
Ligand information
>8g5y Chain S2 (length=1680) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaa
cugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucg
cgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggcc
gaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuau
caacuuucgaugguagucgccgugccuaccauggugaccacgggugacgg
ggaaucaggguucgauuccggagagggagccugagaaacggcuaccacau
ccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggaggu
agugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaa
ugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucugg
ugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcu
gcaguuaaaaagcucguaguuggaucuuuuuacuuugaaaaaauuagagu
guucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaa
uaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaa
gagggacggccgggggcauucguauugcgccgcuagaggugaaauucuug
gaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuuca
uuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucgua
guuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccau
gacccgccgggcagcuuccgggaaaccaaagucuuuggguuccgggggga
guaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacca
ggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccgg
cccggacacggacaggauugacagauugauagcucuuucucgauuccgug
ggugguggugcauggccguucuuaguugguggagcgauuugucugguuaa
uuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccg
agcggucggcgucccccaacuucuuagagggacaaguggcguucagccac
ccgagauugagcaauaacaggucugugaugcccuuagauguccggggcug
cacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcag
gcgcggguaacccguugaaccccauucgugauggggaucggggauugcaa
uuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugc
guugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgau
uggaugguuuagugaggcccucggaucggccccgccggcggagcgcugag
aagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguu
uccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<..................<<.....
<<.<<<.....>>>.>>......>>.........<<<<...<<<<<....
..>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>.
..<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<..
..<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<
.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<
<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>
..>...>>.>.....<<<<<<<<<.<<<....>>.>.>>>>>.>>>>...
...<<..<...........>..>>.........<<<<<((......<<<<
.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>........
.<.<((.....<.<<...<<<.<<.....<<<<<<.<.......<<...<
.......>.<<<<.......>>>>...>>......>.>>>..>>>.....
...<.<<.<<<<<<<...............>>>>>>>.>>.>....>>..
..<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>...
...>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>.
..>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...
>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>
>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<..
....<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..
<<<<<..<<<.<<<<<.......<<........>>..........<<<<<
.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>
...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<....
..>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<....
...>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>
........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....
>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>
>>>.>>>....>.........>>>.>>............<<<<<......
....>>>>>...........>>>>>.....<<<<<<<<.......>>>>>
>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<...
.<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<..>>>>...>>>>>.
..>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<
<<<<<<<<<..>>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g5y mRNA decoding in human is kinetically and structurally distinct from bacteria.
Resolution2.29 Å
Binding residue
(original residue number in PDB)
R73 K77 I109 A112 K113 K116
Binding residue
(residue number reindexed from 1)
R67 K71 I103 A106 K107 K110
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0045296 cadherin binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0010458 exit from mitosis
GO:0021554 optic nerve development
GO:0031290 retinal ganglion cell axon guidance
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8g5y, PDBe:8g5y, PDBj:8g5y
PDBsum8g5y
PubMed37020024
UniProtP83731|RL24_HUMAN Large ribosomal subunit protein eL24 (Gene Name=RPL24)

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