Structure of PDB 5wlc Chain LW Binding Site BS01

Receptor Information
>5wlc Chain LW (length=438) Species: 1247190 (Saccharomyces cerevisiae BY4741) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QTKDKKLRAGLKKIDEQYKKAVSSAAATDYLLPESNGYLEPENELEKTFK
VQQSEIKSSVDVSTANKALDLSLKEFGPYHIKYAKNGTHLLITGRKGHVA
SMDWRKGQLRAELFLNETCHSATYLQNEQYFAVAQKKYTFIYDHEGTELH
RLKQHIEARHLDFLPYHYLLVTAGETGWLKYHDVSTGQLVSELRTKAGPT
MAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIAIDRS
GYYMATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSISDTGLLALSRG
PHVTLWKDALKLSGDSKPCFGSMGGNPHRNTPYMSHLFAGNKVENLGFVP
FEDLLGVGHQTGITNLIVPGAGEANYDALELNPFETKKQRQEQEVRTLLN
KLPADTITLDPNSIGSVDKRSSTIRLNAKDLAQTTMDA
Ligand information
>5wlc Chain L0 (length=488) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaagacaagugcuugucguucguuaauggccucgucaaacgguggagaga
gucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaau
ugacauggguugaugcguauugagagauacaauuugggaagaaauuccca
gaguguguuucuuuugcguuuaaccugaacagucucaucgugggcaucuu
gcgauuccauuggugagcagcgaaggauuugguggauuacuagcuaauag
caaucuauuucaaagaauucaaacuugggggaaugccuuguugaauauuc
uucaaguguaaccuccucucaaaucagcgauaucaaacguaccccgugaa
acaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagu
gcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuug
aacagagagcauuuccggcagcagagauuucagcuguu
<<<<<<<<<..>>>>>>.>>>............<<<<<<<<.<<...<<<
<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>...>>.>>>......>
>>>>..<<<<<<..<<<<<..<<<<<<<<<<.<<<<<<<<....>>>>>>
>>.>>>>>>>>>>.>>>>>.>>>>>>.......<<<<<<<<<<<......
.....>>>>>.>>>>>>.........................<<<...>>
>.........................<<<<<..<<<<<<<..<<<..>>>
..>>>>.>>.>>>>>>.....<<<<<<...<<<<<<<<<<<<<<<<....
....>>>>>>>.>.>>>>>>>>....>>>>>>..................
...............<<<<<<<<.<<<.<<<<<<<<......>>>>.>>>
>.>>>...>>>>.>>>><<<<<.<<<..>>>.>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5wlc The complete structure of the small-subunit processome.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		F84 K85 Q143 K172 H179 I191 T211 W213 K215 L224 E227 K231 A232 G233 R274 P316 F355 G356 S357 M358 G359 G360 R364 A374 Q426
Binding residue
(residue number reindexed from 1)		F49 K50 Q108 K137 H144 I156 T176 W178 K180 L189 E192 K196 A197 G198 R239 P281 F320 G321 S322 M323 G324 G325 R329 A339 Q391
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0030688 preribosome, small subunit precursor
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5wlc, PDBe:5wlc, PDBj:5wlc
PDBsum5wlc
PubMed28945246
UniProtP40055|UTP7_YEAST U3 small nucleolar RNA-associated protein 7 (Gene Name=UTP7)

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