Structure of PDB 5wlc Chain LV Binding Site BS01

Receptor Information

>5wlc Chain LV (length=362) Species: 1247190 (Saccharomyces cerevisiae BY4741)

VLKSTSANDVSVYQVSGTNVSRSLPDWIAKKRKRQLKNDLEYQNRVELIQ
DFEFSEASNKIKVSRDGQYCMATGTYKPQIHVYDFANLSLKFDRHTDAEN
VDFTILSDDWTKSVHLQNDRSIQFQNKGGLHYTTRIPKFGRSLVYNKVNC
DLYVGASGNELYRLNLEKGRFLNPFKLDTEGVNHVSINEVNGLLAAGTET
NVVEFWDPRSRSRVSKLYLENNIDNRPFQVTTTSFRNDGLTFACGTSNGY
SYIYDLRTSEPSIIKDQGYGFDIKKIIWLDNVGTENKIVTCDKRIAKIWD
RLDGKAYASMEPSVDINDIEHVPGTGMFFTANESIPMHTYYIPSLGPSPR
WCSFLDSITEEL

Ligand information

>5wlc Chain L1 (length=1025)

agauaguuaucugguugauccugccaguagucauaugcuugucucagcca
ugcagcucauuaaaucaguuaucguuuauuugauagucaugguauaacug
ugguaauucuagagcuaaaaucucgacccuuuggaagagauguauuuauu
agaucaaugucuucggacucuuugaugaauaacuuuucgaaucgcauggc
cuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaug
guaggauaguggccuaccaugguuucaacggguaacggggaauaaggguu
cgauuccggagagggagccugagaaacggcuaccacauccaaggaagggc
aggcuuacccaauccuaauucagggagguagugacaauaaauaacgauac
agggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuua
acgaggaacaauuggagggcaagucuggugccagcagccgcgguaauucc
agcuccaauagcguauauuagcucguaguugaacuauuaauagggacggu
cgggggcaucaguauucaauugucagaggugaaauucuuggauuuauuga
agacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaaga
acgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaagga
guauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccacca
ggaguggagccugcggcucaacacggggaaacucaccagguccagacaca
auauuugugggugguggugcaugugaugcccuuguucuggcgcgcgcuac
acugacggagccagcgagucuaaccuuggccgagaggucuugguaaaaac
uccgucggggaacgaggaauuccuaguaagcgcaagucaucagcuugcgu
ugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccggaac
uaauuccguaggugaaccugcggaa

.............................<<.<<<<<<........<<<.
<<<..<<<.......<<<..<<..<<....<<<..............<<.
<<<.....>>>.>>.....<<<<<..<<....>>..>>>>>....<<<<.
...<<<<.<<<....>>>...>>>>...>>>>.........<<<<..<<<
.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<.....<<<
<<<<<.......>>>>>>>>.>>......>>>....<<<...<.......
.>..>>>.>>>.<<.<<<..........>>>.>>.<.<<....>>.>.>>
>>>>..<<<....<<<.....>>>..>>>...............<<<<<<
<.<<<<<....>>>>>.>>>.>>>>......<<..<..<....>...>..
>>.........<<<<<<.......<<<....>>>................
..>>>>>>..>>>>>>>>..<.<<...<<<.<<...>>....<<<<<<.<
<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>
>.>>>......<<<....>>>..>>>>..>>.>>>.>>>...>>>...>>
.>.....<<<<<<...<...<<<<.........>>>>...>>>>>>>...
..............<<.........>>.....<<<<<<<<<<<<..<<.<
<<<<<..<<<.<<<<....................<<<<<......<<<<
<...>>>>>......<<<<<<..>>.>>>>.....>>>>>>>>>.>>>..
...<<<<<<<............<<<..<<<<....>>>>..>>>.....>
>>>>>>............>>>>>>....<<<<<<<.........>>>>>>
>......>>...>>>>>>>............>>>>>..<<<<.<<>>.>>
>>.<<<<<<<<<....>>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5wlc The complete structure of the small-subunit processome.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): R33 K34 K78 K92 R95 H96 R121 G130
• Binding residue (residue number reindexed from 1): R32 K33 K77 K91 R94 H95 R120 G129

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0005515 protein binding

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0030686 90S preribosome
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:5wlc, PDBe:5wlc, PDBj:5wlc
• PDBsum: 5wlc
• PubMed: 28945246
• UniProt: P48234|NOL10_YEAST Ribosome biogenesis protein ENP2 (Gene Name=ENP2)