Structure of PDB 8fky Chain LU Binding Site BS01

Receptor Information

>8fky Chain LU (length=102) Species: 9606 (Homo sapiens)

ALRYPMAVGLNKGHKVTKNVSKPRHSRRRGRLTKHTKFVRDMIREVCGFA
PYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAA
AK

Ligand information

>8fky Chain L3 (length=2585)

gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcgg
aggagaagaaacuaaccaggauucccucaguaacggcgagugaacaggga
agagcccagcgccgaauccccgccccgggggcgcgggacauguggcguac
ggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugau
cgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgc
cgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagc
gggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaag
uaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggc
gugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggag
gauucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggug
cgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggc
ucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccg
gggccgagggagcgccgcgcucuccggccgggccaggccacggagcgcac
ggggucggcggcgacgucggcuacccacccgacccgucuugaaacacgga
ccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccg
uggcgcaaggugggaucccgaggcccgccgagggcgcaccaccggcccgu
cucgcccggggagguggagcacgagcgcacguguuaggacccgaaagaug
gugaacuaugcaagccagaggaaacucugguggguauaggggcgaaagac
uaaccaucuaguagcugguucccuccgaaguuucccggauagcuggcgcu
cucgcgcaguuuuauccgguggguaagaagcccggcucgagccgggcgug
gaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcg
ggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagac
cccagaaaagguguugguugauauagacagcaggacgguggccauggaag
ucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagc
ccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccg
gcagucacgcuacgccgcgacgaguaggagggccgcugcggugagccuug
aagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggu
gguaguagcuucaaacgagaacuuugaaggccgaaguggagaaggguucc
auguacaugggucagucgguccuagggacgggcgauggccuccggcccgc
cggggagucggguucagauccccgaauccggaguggcggagaugggcgcc
gcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcggga
gccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaau
ggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccg
gcggcguccggugagcucucgcuggcaauccgggggagaggguguaaauc
ucgcgccgggccguacccuccaaggugaacagccucuggcaauguaggua
agggaagucgggaauccgauucccacugucccuaccuacuauccagcgaa
accacagccaagggaacgggcuuggcggaaucagcggggagaagacccug
uugagcuugacucuagucuggcacggugaagagacaugagagguguagaa
uaagugggaggcggccgccggugaaauaccacuacucugaucguuuuuuc
cagugccagguggggaguuauccuucugaccuuuuggguuuuaagcagga
ggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgc
gacgucgcuuuuugaugaugucggcucuuccuaucauugugaagcagaau
ucaccaagcguuggauuguucacccacuaauagggaacgugagcugggga
ccgucgugagacagguuagucccuacugaugguuguugccaugguaaucc
ugcucaguacgagaggaaccgcagguucagacauuugguggugcuuggcu
gaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgcc
ucuaagucagaaucccgcccaggcggaacgauacagcgccgcggagccuc
gguuggccucggauagccgguccccgggguccggugcggagugcccuucg
uccugggaaacggggcgcggccggagaggcggccgcccccucgcccguca
cgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgacc
ugcuucugggucgggguuucguacguagcagagcagcucccucgcugcga
ucuauugaaagucagcccucgacacaaggguuugu

........................<<<<<<...............>>>>>
.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>
>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..
<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<.....
.>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>
>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....
<<<<<<.>>>>>>..>>>................................
..<<....>>...............<<<<....>>>>.............
.....................<<<<<<<<..<<<.<<...<<<<<<<<.<
<<.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>..
.<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<
<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>
>>>>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>>>>>>>..
....>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><
<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>....
.>>>....<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<
<<<.<<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<
<<...<<<<<...<<<<<<<....>>>>>>>...>>>>><<.<....>.>
>.>>>>>>......>.>>..<<<<<<......<<<.>>>..<<.<<<<<<
<....<<<.<<<<<<<<...>>>>>>...<<<<<<<<..>>>>>>>>...
.>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<
<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..
........<<<.<<<<<<<<<<.....<.<<<<<.<<<...<<.......
..>>...>>>.........<<......>>...>>>>>.>.>>>>>>>>>>
>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<
<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<....
..<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>>
<<.....<<<<<<<<.......>>>>>>.<<<.....<<<<..<<...<<
<<<..>>>>>....((<<<<<...<<...<<<<...........>>>>.>
>..>...<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<
....>>>>>>>...<<<....>>>......<<<<<<<...<<<<<<<<<<
<..<<<<<<<<<<.......>>>>>>.....<<<<.<<<<.<<<<.....
<<<.....>>>.....>>>>>>>>..>>>>......<<<<<<<.......
>>>>>>>>>>>....>>>>>>>>>>>..>>>>>>>.............>>
.>>>.>>>>>>>>..>>>>>>.<<<<.....>>>>..>>>...<<<<<<.
<<<<<<<<..<<<<<<.>>>>>>.>>>.>>>>>>>>>>>......>>...
.>>...<<<<<<........>>>>>>....<<<<.<<<<......<<<<<
<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<........
..<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>
..>>>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>>>>
>>........>>>>>.>.>>>>>>.............<<<<<<...<..>
...>>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<......>
>>>>...>.>.<<<.....))..>>>.....>>>>>....>>>>>>..<<
<<<<<....>>>.>>>>...>>>>.>>>>..<<<<<<.<..<<<..<.<<
<<<.................>>>>>.><<<<....<<<<.<<.<<<<<<<
....>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<.......
....>>>>>...>>>>>.>>>...>.>>>>>>..<<<<<<<.<<..<<<<
....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<
<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>
>>..............>>>>..>>>>>>>>><<<<<.<............
.>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..
>>>>>....>>....>>>>.>>>.>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fky Principles of human pre-60 S biogenesis.
• Resolution: 2.67 Å
• Binding residue (original residue number in PDB): H15 V17 R25 H26 S27 R28 R29 R30 G31 R32 L33 T34 H36 R41 Y53 R76 R82 R85
• Binding residue (residue number reindexed from 1): H14 V16 R24 H25 S26 R27 R28 R29 G30 R31 L32 T33 H35 R40 Y52 R75 R81 R84

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8fky, PDBe:8fky, PDBj:8fky
• PDBsum: 8fky
• PubMed: 37410842
• UniProt: Q9Y3U8|RL36_HUMAN Large ribosomal subunit protein eL36 (Gene Name=RPL36)