Structure of PDB 8fkq Chain LU Binding Site BS01

Receptor Information

>8fkq Chain LU (length=102) Species: 9606 (Homo sapiens)

ALRYPMAVGLNKGHKVTKNVSKPRHSRRRGRLTKHTKFVRDMIREVCGFA
PYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAA
AK

Ligand information

>8fkq Chain L3 (length=1565)

gcgaccucagaucagacguggcgacccgcuggcauauuagucagcggagg
agaagaaacuaaccaggauucccucaguaacggcgagugaacagggaaga
gcccagcgccgaauccccgccccgggggcgcgggacauguggcguacgga
agacccgcuccccggcgccgcucguggggggcccaaguccuucugaucga
ggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgg
gcccgggucuucccggagucggguugcuugggaaugcagcccaaagcggg
ugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguac
cguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgug
aaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauuc
aacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccg
cgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggg
cccgaguguuacagcccccccggcagcagcacucgccgaaucccggggcc
gagggagcgccgcgcucuccggccgggccaggccacgcgagcgcacgggg
ucggcggcgacgucggcuacccacccgacccgucuacacggaccaaggag
ucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaa
ggugggaucccgaggccgccgagggcgcaccaccggccgcacgagcgcac
guguuaggacccgaaagauggugaaaccaucuaguagcugguucccuccg
aaguuucccucaggauagcuggcgcucucgcaguuuuauccgguggguaa
gaagccggcguggaaugcgagugccuagugggccacuuuuagaacuggcg
cugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucgg
cgcuggagcgucgggcccauacccggccgucgccggcagucacgcuacgc
cgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgg
gcccggguggagccgccgcaggugcagaucuuggugguaguagcaauguu
ggaacaauguaggaccuacuauccagcgaaaccucagcacugaugauguu
guugccaugguaauccugcucaguacgagaggaaccgcagguucagacau
uugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugu
gggcccgcccaggcggaacgauagcgccgcggagccucgguuggccucgg
auagccgguccccgggguccggugcggagugcccuucguccugggaaacg
gggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacgu
ucguggggaaccuggcgcuaaaccauucguagacgaccugcugggucggg
guuucguacguagcagagcagcucccucgcugcgaucuauugaaagagcc
cucgacacgguuugu

........................<<<<<<............>>>>>.>.
........<<....>>..<<<<<<.....<<.....>>....>>>>>>..
<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<
<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>
>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>
>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<
<<<.>>>>>>..>>>..................................<
<....>>...............<<<<....>>>>................
................<<<<<<<<.<<<<.<<...<<<<<<<<.<<<...
..<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<
<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<.
.>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>
>..........<<<<<<.<..>.<<<<<<.>>>>.>>.>>>>>>......
>>.>>>>>...>>>>>..>>>>>>>>>..<<<<....>>>><<<<<<...
.<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....
<<<<<...<<<..<<<.>>>..>>>....>>>>>.<<.>>....>>>>>>
>>>>>>>..<<.<...<<<<<<...>>>>>>......>.>>..<<<<<<.
...<.<<<....>>>.><<.<<<<<<<..<<<.<<<<<<<<...>>>>>>
...<<..>>....>>>>>>>>>>>>..>>..<<<<.<<<..>>>.>>>>.
...<<<......>>>...<<<<<<<...<<<(((.......<<<<<..))
)......>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>
>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....
>>>>>>>>...>>>>>>>>>>..>.....>>>>>>.<.....<......<
<<<.....<<<<<.>>>>>..>>>>.>....>.<<<<..>>>>....<<<
<<<.<..<<<....<<<<<.................>>>>>..<<<<...
.<<<<.....<..<<<<<<....>>>>>>....>....>>>>...>>>><
<<..>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<.....
...<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<
<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..........
....>>>>..>>>>>>>>.<<<<<.<.............>....<<<<<<
<<<<.....<<<<....<<<<<......>>>>>...>>>>....>>.>>>
>>.>>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fkq Principles of human pre-60 S biogenesis.
• Resolution: 2.76 Å
• Binding residue (original residue number in PDB): H15 V17 K23 R25 H26 S27 R28 R29 R30 G31 R32 L33 H36 R41 Y53 R76 R82 R85
• Binding residue (residue number reindexed from 1): H14 V16 K22 R24 H25 S26 R27 R28 R29 G30 R31 L32 H35 R40 Y52 R75 R81 R84

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8fkq, PDBe:8fkq, PDBj:8fkq
• PDBsum: 8fkq
• PubMed: 37410842
• UniProt: Q9Y3U8|RL36_HUMAN Large ribosomal subunit protein eL36 (Gene Name=RPL36)