Structure of PDB 7mqa Chain LR Binding Site BS01

Receptor Information

>7mqa Chain LR (length=772) Species: 9606 (Homo sapiens)

FKTNYAVERKIEPFYKGGKAQLDQTGQHLFCVCGTRVNILEVASGAVLRS
LEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLWKAIHTA
PVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFH
PDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTM
LSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGL
YFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTA
TADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLK
VFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQ
VMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSNGP
ILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGV
FSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASV
LKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRL
DDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVVRQQELDNLLHEKRY
LRALGLAISLDRPHTVLTVIQAIRRDPEACEKLEATMLRLRRDQKEALLR
FCVTWNTNSRHCHEAQAVLGVLLRREAPEELLAYEGVRAALEALLPYTER
HFQRLSRTLQAAAFLDFLWHNM

Ligand information

>7mqa Chain L1 (length=1636)

accugguugauccugccaguagcauaugcuugucucaaagauuaagccau
gcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauu
aaaucaguuaugguuccuuuggucgcucgcuccuuacuuggauaacugug
guaauucuagagcuaauacaugccgacgggcgcugacccccggggggaug
cgugcauuuaucagaucaaaaccaacccgccccucgggcgggcgccggcg
gcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcg
gcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgcc
gugccuaccauggugaccacgggugacggggaaucaggguucgauuccgg
agagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcg
caaauuacccacucccgacccggggagguagugacgaaaaauaacaauac
aggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuu
aacgaggauccauuggagggcaagucuggugccagcagccgcgguagcuc
caauagcguauauuaaacugcaguuaaaaagcucguaguuggaucuuggg
agcgggcgggcgguccagccaccgcccguccccgccccuugccucucggc
gccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcc
ccgccuggauaccgcagcuaggaauaauggggaccgcgguucuaggaacu
gaggccaugauuaagagggacggccgggggcauucguauugcgccgcuag
aggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugc
caagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgau
cagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggc
ggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuu
ggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacg
gaagggcaccaccaggaguggagccugcggcacccggcccggacacggac
aggauugacagauugauagcucuuucucgauuccguggguuggugcaugg
ccguucguugguggagcgauuugguuaauuccgauaacgaacgagacucu
ggcaugcuagagggacaaguggcguucagccacccgagauugagcaauaa
caggucugugaugcccguccggggcacgcgcgcuacacugacuggcucag
cguguguacgccggcaggcgcgaaccccauucgugauggggaucggggau
uauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcg
uugauuaagucccugcccuuucacaccgcccgucgcuacuaccgauugga
ugguuuagugaggcccucggaucggccccgccggggucggcccacggccc
uggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaa
aguuccguaggugaaccugcggaaggaucauuaacg

..<<<<<.......>>>>>.<<.<<<<<<...<.<<.........<<<.<
<<..<<....<<....<<..........>>...>>.>>......<<....
....<<<.<....<<....<<<................<<.....<<.<<
.......>>.>>......>>.........<<<<...<<<<..>>>>...>
>>><<..<<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>
..>>...........>>>>>......>>...<<<<.<<<<......>>>>
>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.....
....>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.
>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>...
......<<<....<<<.....>>>..>>>......>>.>.....<<<<<<
<<<.<<<....>>>.>.>>>>.>>>>......<<..<...........>.
.>>.........<<<<<<.......<<<....>>>............>>>
>>>..>>>>>>.>>......<.<((.....<.<<...<<<.<<<<<.<<<
.<<<<<<<<<<<<<......>>>>>>>>>..>>>>>>>.<<<...<<<<.
<<..>>>>>>.>>>.<<<<<<.<.......<<..<<.......>>.<<<.
..>>>....>>......>.>>>..>>>.>><<.<<.<<<<<<<.>>>>>>
>.>>>>...>>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<
<<......>>>......>>>>>>>>..>>.......<<....>>...>>>
>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<..
.......>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<
<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>....
.>>>.>.>......................................<<<<
<<<<<<<<..<<..<<<<<..<<<.<<<<<<.<<<<<......<<<<<<.
......<<.<<<........>>>.>>.....>>>>>>....<<<.<<<<<
<<<<<.<<<.<<.<<....>>.<<......>>....>>.>>>....<<<.
..<...<..>..>.....<<<<<.....>>>>>........>>>....>>
>.>>.>>>>>..>>>...>>>>>>>.>>>>.>>>.....<<.<<<.....
........<<<<....>>>>......>>>.>>......<.....<<<<<.
<>.>>>>>.....>.....>>>>>.....<<<<<<<.........>>>>>
>>......>>...>>>>>>>.........>>>>>..<<<<.<<..<.<<<
<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>
>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>.>.>>.>>>>..
..<<<<<<<<<....>>>>>>>>>............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7mqa Nucleolar maturation of the human small subunit processome.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): H422 R522 N724 S725 R726 R773
• Binding residue (residue number reindexed from 1): H412 R506 N708 S709 R710 R757

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0034511 U3 snoRNA binding

Biological Process

• GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006364 rRNA processing
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0030686 90S preribosome
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:7mqa, PDBe:7mqa, PDBj:7mqa
• PDBsum: 7mqa
• PubMed: 34516797
• UniProt: Q12788|TBL3_HUMAN Transducin beta-like protein 3 (Gene Name=TBL3)