Structure of PDB 8rxx Chain LQ Binding Site BS01

Receptor Information
>8rxx Chain LQ (length=201) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSLKLQARLASSILGCGRARVWLDPNEAVEIQNANSRKSVRKLIKDGFII
RKPVKVHSRARWRKMKEAKDMGRHNGVGRREGSREARMPSKELWMRRLRI
LRRLLRKYRADKKIDRHVYRDLYMRAKGNVFRNKRNLVEHIHKIKNEKKK
ERQLAEQLAAKHLRDEQNRNKARKQELKKREKERERARRDDAAAAAQKKK
A
Ligand information
>8rxx Chain L1 (length=1657) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucauugugugguuggugcaggaguggcgaaauucaagcgaaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacaagcgagua
gcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaag
uuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaag
uuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugaca
aagacaauggaaguaccuccauuucaacggccagaaccagcccuacugca
uuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaucuu
gggucuuggugaaaugagcggaguauuugagcugcgcacggcggccgcac
gcacugguuucuucuccgugaugcuccauguuggcgauggaaauggggug
cccccacccgucuugaaacacggaccaaggagucaaacagacgcgcaagg
gaggagauaugguugccaguacuucucucguacugaaagggagaugcaaa
augcaucuguggugugcacacgucaaauccguuugauuugcccaacaccg
accggcccuccguggguugcguuggagugugccuguuuggacccgaaagg
uggugaacuaugccugaacaaggugaagcccggggaaacccagguggagg
ccuguagcgaugcugacgugcaaaucgcucguaugauuuggguaucggag
cgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucccu
caggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauuag
agggaccuauucucaaacuuuaaaugugcaaacaaaccgugccuuagcca
acugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuuc
gguaagcggagcaggcgaugcggaaugaaccgcuuagggauauguggcgu
caaaacuuaugggcucauucucgauacgugaaaaggguguugguggauaa
auccaccggccccgaaaauggaugacgcuuaagcccaauuagugauugcc
cauuauuccuuugguaagggcggaaacaaauggagaaaguguagcccuuc
cgauguagauguggccuggagguuaggacgaagcuuauggcgugagccua
agauggaccggccucuagugcagaucuugguuggcguagcaaagaucuaa
cggagauauacucaacaugcaacguuggauacuggagcggggaaggauuu
cgugccaacggcacucguacacgaguuguucggaaacugagcacaacguu
auaucguuuuguuaggaaagugaaggugugucggcggagcuguucgacug
ugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugca
uguggga
......................<<<<<......<......>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
............<<<<...<<<<<<<<.<<<<<......<<<......<<
<<.......>>>>.....<<........>>......>>>.<<.......(
(.....>>)).....>>>>>...>>>..>>>>>.>>>>............
<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>
>....................................<<....>>.....
...........<<<<....>>>>...........................
.......<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<
<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>.........
>>>>..>>>>........<<<<<.....<<<<<<.<<.<<<<.>>>>...
>>.>.>>>.>>..>>>>>.....<<<<...>>>>>>....>>>>>>>>>>
>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..<<
<..<<<.<............>>>>..>>>...<<....>>..<<<<<...
..>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><
<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<...<<
<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....
>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<
.......>>......>>>>>>......>.>>...<<<<<....<.<<<..
..>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<...<.
<<<..>>>.>...>>..>>.>...>>>>>>>.....<<<.<<<<<.<<..
...>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<
<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<((
(......<..<<<<........<...........<<<.<<<<<<<<<<..
>>>>>>>>>>>>>..........))).>....>>>>.>.........>>>
...>>>>>>><<<<.<<<<<...........>>>>.........>>>>>>
>>>....>>>>>....<<<<<<<<.........<<<..<<<....>>>.>
>>.......>>>>>>>>........>>>>>>..............<<<<<
<<....................>>>>>>>....................<
<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<..
....>>>>............<.......<<...<......>...>>....
.>.....>.>>..........<<<<.........>>....>>.>>.....
.......
Receptor-Ligand Complex Structure
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PDB8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		V2 S3 L4 R9 L10 R19 W23 L24 P26 S37 R38 R42 K92 W95 M125 K128 G129 N130
Binding residue
(residue number reindexed from 1)		V1 S2 L3 R8 L9 R18 W22 L23 P25 S36 R37 R41 K91 W94 M124 K127 G128 N129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
PDBsum8rxx
PubMed38722744
UniProtQ4QJ37

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