Structure of PDB 7mqa Chain LQ Binding Site BS01

Receptor Information

>7mqa Chain LQ (length=830) Species: 9606 (Homo sapiens)

KQYLRYVASAVFGVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRK
GEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN
GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQ
ALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEK
RLITGASDSELRVWDIAYLPEDRILSCRKAGSIMREGRDRVVNLAVDKTG
RILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHPEVNVEMSL
QDEIQRVTNIKTSAKIKSFDLIHSELKAVFLLQNNLVELYSLNPVRTSRI
TIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALC
SFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQR
GFVTGGADKSVKFWDFERLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLL
DCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWG
LDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQ
TLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMER
EATVKAAERIMEAIELYREETAKMKEHKAICKNPILMAYGSISPSAYVLE
IFKGIKSSELEESLLVLPFSYVPDILKLFNEFIQLGSDVELICRCLFFLL
RIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMAGLDYLKRECE
AKSEVMFFADATSHLEEKKRKRKKREKLIL

Ligand information

>7mqa Chain L1 (length=1636)

accugguugauccugccaguagcauaugcuugucucaaagauuaagccau
gcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauu
aaaucaguuaugguuccuuuggucgcucgcuccuuacuuggauaacugug
guaauucuagagcuaauacaugccgacgggcgcugacccccggggggaug
cgugcauuuaucagaucaaaaccaacccgccccucgggcgggcgccggcg
gcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcg
gcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgcc
gugccuaccauggugaccacgggugacggggaaucaggguucgauuccgg
agagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcg
caaauuacccacucccgacccggggagguagugacgaaaaauaacaauac
aggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuu
aacgaggauccauuggagggcaagucuggugccagcagccgcgguagcuc
caauagcguauauuaaacugcaguuaaaaagcucguaguuggaucuuggg
agcgggcgggcgguccagccaccgcccguccccgccccuugccucucggc
gccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcc
ccgccuggauaccgcagcuaggaauaauggggaccgcgguucuaggaacu
gaggccaugauuaagagggacggccgggggcauucguauugcgccgcuag
aggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugc
caagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgau
cagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggc
ggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuu
ggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacg
gaagggcaccaccaggaguggagccugcggcacccggcccggacacggac
aggauugacagauugauagcucuuucucgauuccguggguuggugcaugg
ccguucguugguggagcgauuugguuaauuccgauaacgaacgagacucu
ggcaugcuagagggacaaguggcguucagccacccgagauugagcaauaa
caggucugugaugcccguccggggcacgcgcgcuacacugacuggcucag
cguguguacgccggcaggcgcgaaccccauucgugauggggaucggggau
uauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcg
uugauuaagucccugcccuuucacaccgcccgucgcuacuaccgauugga
ugguuuagugaggcccucggaucggccccgccggggucggcccacggccc
uggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaa
aguuccguaggugaaccugcggaaggaucauuaacg

..<<<<<.......>>>>>.<<.<<<<<<...<.<<.........<<<.<
<<..<<....<<....<<..........>>...>>.>>......<<....
....<<<.<....<<....<<<................<<.....<<.<<
.......>>.>>......>>.........<<<<...<<<<..>>>>...>
>>><<..<<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>
..>>...........>>>>>......>>...<<<<.<<<<......>>>>
>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.....
....>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.
>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>...
......<<<....<<<.....>>>..>>>......>>.>.....<<<<<<
<<<.<<<....>>>.>.>>>>.>>>>......<<..<...........>.
.>>.........<<<<<<.......<<<....>>>............>>>
>>>..>>>>>>.>>......<.<((.....<.<<...<<<.<<<<<.<<<
.<<<<<<<<<<<<<......>>>>>>>>>..>>>>>>>.<<<...<<<<.
<<..>>>>>>.>>>.<<<<<<.<.......<<..<<.......>>.<<<.
..>>>....>>......>.>>>..>>>.>><<.<<.<<<<<<<.>>>>>>
>.>>>>...>>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<
<<......>>>......>>>>>>>>..>>.......<<....>>...>>>
>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<..
.......>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<
<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>....
.>>>.>.>......................................<<<<
<<<<<<<<..<<..<<<<<..<<<.<<<<<<.<<<<<......<<<<<<.
......<<.<<<........>>>.>>.....>>>>>>....<<<.<<<<<
<<<<<.<<<.<<.<<....>>.<<......>>....>>.>>>....<<<.
..<...<..>..>.....<<<<<.....>>>>>........>>>....>>
>.>>.>>>>>..>>>...>>>>>>>.>>>>.>>>.....<<.<<<.....
........<<<<....>>>>......>>>.>>......<.....<<<<<.
<>.>>>>>.....>.....>>>>>.....<<<<<<<.........>>>>>
>>......>>...>>>>>>>.........>>>>>..<<<<.<<..<.<<<
<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>
>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>.>.>>.>>>>..
..<<<<<<<<<....>>>>>>>>>............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7mqa Nucleolar maturation of the human small subunit processome.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): Q22 K127 E193 W195 R281 K366 R419 K474 Y588 K591 R613 N614 K616 D624 C625 K627 S628 F630
• Binding residue (residue number reindexed from 1): Q18 K123 E189 W191 R240 K317 R360 K415 Y519 K522 R544 N545 K547 D555 C556 K558 S559 F561

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0030515 snoRNA binding

Biological Process

• GO:0030490 maturation of SSU-rRNA
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0031965 nuclear membrane
• GO:0032040 small-subunit processome
• GO:0034388 Pwp2p-containing subcomplex of 90S preribosome

External links

• PDB: RCSB:7mqa, PDBe:7mqa, PDBj:7mqa
• PDBsum: 7mqa
• PubMed: 34516797
• UniProt: Q9UNX4|WDR3_HUMAN WD repeat-containing protein 3 (Gene Name=WDR3)