Structure of PDB 8i9t Chain LP Binding Site BS01

Receptor Information
>8i9t Chain LP (length=154) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRYAATEIAPTKSARARGSYLRVSFKNTRETAQAINGWKLQRALTFLQNV
IDKKEAVPMRRYAGSTGRTAQGKQWGVSRARWPVKSAQFLIGLLKNAEAN
ADAKGLDTGNLIIKHIQVNQAPKQRRPYMSNPCHIELILTEAEETVQKSE
AVVR
Ligand information
>8i9t Chain C1 (length=2132) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaaguga
acguaggugagagcuucggcgcaucaucgaccgauccugauguauucgga
uggauuugaguaggagcguuaagccuuggacccgaaagauggugaacaac
caucuaguagcugguuaccgccgaaguuucccucaggauagcagugucga
ccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcc
cuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggc
cauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguu
aaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacau
cuugacagcaggacgguggccauggaagucggaauccgcuaaggacugug
uaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaa
gcgucccacccauaccccgcccucaggguagaaacgaugcccugaggagu
aggcggccguggaggucagugacgaagccuagggcgugagcccgggucga
acggccucuagugcagaucuuggugguaguagcaaauuugauagaacaau
guagauaagggaagucggcgggaaucugcgagauucccacugucccuauc
uacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcg
gggaagacccuguugagcuugacucuaguuugacauugugaaaagacaua
ggagguguagaauaggugggagcuucggcgccagugaaauaccacuacuc
cuauuguuuuuuuacuuauucaaugugaagacauugucagguggggaguu
ccuuuagucccucgaaauuugaggcuagaggagaaaaguuaccacaggga
uaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuuggaug
ucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguu
cacccacuaauagggaacguggaccgucgugagacagguuagucccuacu
gaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcuga
uucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcu
accaucugcuggauaauggcugaacgccucuaagucagaauccaugccag
aacgcgacgauaacccgcacguagacguauaagaauaggcuccggccucg
uauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauu
cgcguauugcaaagacacgcgcgggaucaaauccuuugcagacgacuuag
augugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucu
gcugaggguaagcccuccuucgccuagauuuc
........................<<<<<<.....<......>......>
>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<<......
>>>>>>..>>>....>.............................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<<....<<.<<<<<<<<<<.<<.<<<
<<<....>>>>>>>>...>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>>
>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<
<<<<<.<<<<..<<<...<<<<.....>>>>...>>>...<<....>>..
.....<<<<<..<<....>>...>>>>>.<<<<<<<<....<....>...
.>>>.>>>.>>....>>>>.>>>>>>>>>.<<.<..<<<<<<<.....>>
>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<<
....<<.<<<<<<<.....<<<........>>.>.....>>>>>....<<
..<<<<.<......>>>>>.>>.......>>>>..>>>>>>>>.>>..<<
<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<.
..<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<
.......<<<<<.<<<...<<.........>>...>>>.........<<.
.....>>...>>>>>...>>>>>>>>>>>>>..........))).>>...
>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>...
.>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...
>>>>>>>>>>..>.....>>>>>><<.....<.........<<<<.....
<<<<<<.<<<<<<<<....<<<<<<<<<>>.>>>>>>>>>>.>>>>>>>>
>>>..>>>>.>....>>....<<<<<........>>>>>....<<<<<.<
<<.....<<<<<<.<<<<<<.<<<<<..<<<<<<<..<<<<<<<<<<<<<
<<<<..........<<<<<......................>>>>>.>>>
>>>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>...>>>>>.
<<<<<<<..<<<<<<...>>>>>>>>>>>>>....>>>>>.>.>>>>>>.
............<<<<<<...<<.......>>...>>>>>>.....((..
......<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.....)
)..>>>.....>>>>>..>..<<<<<<<....>>>.>>>>....>>>.>>
>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>
.><<<<<...<<<<...<<<<<<<<<<<....>>>>>..>>>>>>..>>>
>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>.
...>>>>>>>...<<<<<.<<.......<<.......<<<....>>>...
.>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>
>>>..............>>.>>>>>...<<<<<<<.............>>
....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>
>>...>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8i9t Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Resolution3.6 Å
Binding residue
(original residue number in PDB)
V2 R3 R16 R18 S20 Y21 S25 F26 K27 R30 Q34 R43 R62 Y63 A64 S66 T67 R69 T70 K74 R82 W83 V85 K86 N97 N101 H116 Q118 V119 R126 R127 P138 Y139 M140 T156 V157 Q158 K159
Binding residue
(residue number reindexed from 1)
V1 R2 R15 R17 S19 Y20 S24 F25 K26 R29 Q33 R42 R61 Y62 A63 S65 T66 R68 T69 K73 R81 W82 V84 K85 N96 N100 H115 Q117 V118 R125 R126 P127 Y128 M129 T145 V146 Q147 K148
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8i9t, PDBe:8i9t, PDBj:8i9t
PDBsum8i9t
PubMed37129998
UniProtG0SGY1

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