Structure of PDB 8i9r Chain LP Binding Site BS01

Receptor Information
>8i9r Chain LP (length=154) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRYAATEIAPTKSARARGSYLRVSFKNTRETAQAINGWKLQRALTFLQNV
IDKKEAVPMRRYAGSTGRTAQGKQWGVSRARWPVKSAQFLIGLLKNAEAN
ADAKGLDTGNLIIKHIQVNQAPKQRRPYMSNPCHIELILTEAEETVQKSE
AVVR
Ligand information
>8i9r Chain C1 (length=2048) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaaggugagag
cuucggcgcaucaucgaccgauccugauguauucggauggauuugaguag
gagcguuaagccuuggacccgaaagauggugaacuaugcuugagcauggg
ggcgaaagacuaaucgaaccaucuaguagcugguuaccgccgaaguuucc
cucaggauagcagugucgaccuucaguuuuaugagguaaagcuuuaaaua
uguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucga
cacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccg
aacgcgggguuaaggugccggaguggacgcucacaaaaggcguuaguaca
ucuuauguacuagcccugggcgcucaagcgucccacccauaccccgcccu
caggguagaaacgaugcccugaggaguaggcggccguggaggucagugac
gaagccuagggcgugagcccgggucgaacggccucuagugcagaucuugg
ugguaguagcaaauacuucaaugagaaggugaacagccucugugauagaa
caauguagauaagggaagucacugucccuaucuacuaucuagcgaaacca
cagccaagggaacgggcuuggcaaaaucagcggggaagacccuguugagc
uugacucuaguuugacauugugaaaagacauaggagguguagaauaggug
ggagcuucggcgccagugaaauaccacuacuccuauuguuuuuuuacuua
uucaaugugaagacauugucagguggggaguuggcggcacaucugugcag
guguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaag
gguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaa
guguggccuccuuuagucccucgaaauuugaggcuagaggagaaaaguua
ccacagggaugaccgucgugagacagguuaguucccuacugauacucguc
gcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauug
guuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcugg
auuccaugccagaacgcgacgauaacccgcacgguagacguauaagaaua
ggcuccggccucguauccuagcaggcgauuccuccgccggccucgaagug
gccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaaucc
uuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagc
cuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc
.........................<<<<<.....<......>......>
>>>>...........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<<......
>>>>>>..>>>..................................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<<....<<.<<<<<<<<<<.<<.<<<
<<<....>>>>>>>>...>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>
>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<........>>>><<<<<<...<<<<
<<<<<.<<<<..<<<...<<<<.....>>>>...>>>.....<<<<<..<
<....>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>..
..>>>>.>>>>>>>>>.<<.<..<<<<<<<...<<<<<<<..>>>>>.>>
..<<<..(((((.>>>.>>>>>>...>..>.>>...<<<<<......<<<
....>>>..<<<<<<<<<<....<<.<<<<<<<.<.<.........>.>.
>>>>>....<<..<<<<.<......>>>>>.>>.......>>>>..>>>>
>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>
...<<<<<<<...<<<(((.....<<<<<<.......<<<..<<<<<<<<
<...>>>>>>>>>.>>>.)))......>>>>>>.>>>...>>>>>>><<<
<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<...
...<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>
><<.....<<.......<<<..<<<............>>>..>>><<<<.
....<<<<<<.<<<<<<<<.>>>.>>>>>>>>>>>..>>>>>>....>>.
(..<<<<<......).>>>>>......<<<.<<......<<<<<<.<<<<
<<.<<<<<..<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<
<......................>>>>>.>>>>>>>.>>>>>>>>>>...
<<<<...>>>>.....>>>>>>>...>>>>>.<<<...<<<<<<<..>>>
>>>>.....<<<<<<<...<<<<<<.......>>>>>>.....<<.....
.>>....>>>>>>>....<<<<.<.<<<.....>>>.>>>>>.<<<....
>>>..>>>.<<<<<<<..<<<<<<...>>>>>>>>>>>>>....>>>>>.
>.>>>>>>....<<<<<....>>>.>>.))))).>>..>>>....<<<<<
<<..<<<<...<<<<<.................>>>>>..<<<<<...<<
<<.<<<<<<<<<<<<<....>>>>>..>>>>>>>>>>>>..>>>>>.<<<
<.>>>>.>>>>....>>>>>>>...<<<<<...<<......<<.......
<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>
>>>>.>>>....>>>>..............>>....>>>>>...<<<<<<
<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<
......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
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PDB8i9r Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		V2 R3 R16 R18 S20 Y21 S25 F26 R30 K54 R62 Y63 A64 T67 R82 W83 K86 N101 H116 V119 R126 R127 Y139 M140 S141 N142 E154 V157 Q158 K159
Binding residue
(residue number reindexed from 1)		V1 R2 R15 R17 S19 Y20 S24 F25 R29 K53 R61 Y62 A63 T66 R81 W82 K85 N100 H115 V118 R125 R126 Y128 M129 S130 N131 E143 V146 Q147 K148
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8i9r, PDBe:8i9r, PDBj:8i9r
PDBsum8i9r
PubMed37129998
UniProtG0SGY1

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