Structure of PDB 5t7v Chain LP Binding Site BS01

Receptor Information
>5t7v Chain LP (length=136) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLLPKRVKYRRQHRPKTTGRSKGGNYVTFGEFGLQATTTSWITSRQIESA
RIAMTRYMKRGGKVWIKIFPHTPYTKKPLEVRMGAGKGAVEGWIAVVKPG
RILFEVAGVSEEVAREALRLASHKLPVKTKFVKREE
Ligand information
>5t7v Chain B (length=2768) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gauuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgau
gaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuu
gauccagagauuuccgaauggggaaacccagcaugaguuaugucauguua
ucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaa
caucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcg
gcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguug
uaggacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaa
agaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucu
ugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugg
gaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaacca
guaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaa
ccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggc
gugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaag
caguaaauguggagccguagcgaaagcgagucugaauagggcguuuagua
uuuggucguagacccgaaaccaggugaucuacccuuggucagguugaagu
ucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagc
ggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcug
guucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggag
guagagcacuguuuggucagacaaacuccgaaugccaauuaauuuaacuu
gggagucagaacaugggugauaagguccguguucgaaagggaaacagccc
agaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugg
cguugcccagacaacuggagugcguaauagcucacuagucgagugacacu
gcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguc
cuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucgua
aggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaag
acgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcu
cguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggc
gauggauaacagguugauauuccuguaccaccuauaaucguaucgauggg
gggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagca
guaaggcugaguaauccgguacucgggcugagcugugauggggagaagac
auugugucuucgagucguugauuucacacugccgagaaaagccucuagau
agaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaa
uucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccc
cguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagcc
gcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcua
aaccguaaggugauguauaggggcugacgccugcccagugcuggaagguu
aagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaac
ggcggccguaacuauaacgguccuaagguagcgaaauuccuugucgggua
aguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgag
agacucggugaaaucauaguaccugugaagaugcagguuacccgcgacag
gacggaaagaccccguggagcuuuacuguagccugauauugaaauucggc
acagcuagcuguguuggcuuucuaacccgcaccacuuaucguggugggag
acagugucaggcgggcaguuugacuggggcggucgccuccuaaaagguaa
cggaggcgcucaaagguucccucagaaugguuggaaaucauucauagagu
guaaaggcauaagggagcuugacugcgagaccuacaagucgagcaggguc
gaaagacggacuuagugauccggugguuccgcauggaagggccaucgcuc
aacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguu
cacaucgacggggagguuuggcaccucgaugucggcucaucgcauccugg
ggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacg
cgagcuggguucagaacgucgugagacguucggucccuauccgucguggg
cguaggaaauuugagaggagcuguccuuaguacgagaggaccgggaugga
cauaccucugguguaccaguugucgugccaacggcauagcuggguagcua
uguguggacgggauaagugcugaaagcaucuaagcaugaagccccccuca
agaugagauuucccaacuucgguuauaagaucccucaaagaugaugaggu
uaauagguucgagguggaagcauggugacauguggagcugacgaauacua
aucgaucgaagacuuaau
..<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<...
...<<.<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>...
..>>>>>>>....>>....<<<....>>>.<<<<<<......>>>>>>..
<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<...
...>.......>>>>.>.........<<....>>..<<<<<......<<.
....>>.....>>>>>..(((....<<<<<..........>>>>>.....
.<<<<<<<<<...<.........<<<..<<<<<.<<<...<<<<<.....
.>>>>>((......<<<.....))>>>...>>>.>..>>>>..>>>...>
.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<
<<<..<<<<>>>>>..)))......]].>>>>>>>.]]............
...<<....>>....]].........<<<......>>>............
.}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>
...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<
<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>
>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<
<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>
>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>
>..<<<<<<....<<<<<....>>>>><<.<<<<<<...<<<<<<<<<..
....<<...<<<<<<..>>>>>>..>>.......>>>>.>>>>>..>>>>
>>..>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>
...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<
.<<<<........<<<.....<<......>>.....>>>....>>>>.>>
>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<
.....>>>>>>....>>>>>>..<<<<<<<.<.......<<<<<.<<...
.>>.>>>>>....>.>>>>>>>........>>>>>><......<.....<
<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<..
...>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>
..>>>....<<<<........>>>>.))<<<<<<<......<<<...<<<
<....<<<<...<<...<.......<<...[.....>>....<....<<<
<...<<<...................>>>...>>>>.....>.....<..
.........>........>....>>...>>>.>........>>>>..>>>
.....>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<......
.>>>..>>>>..<<<<....<<<<<<<..<<.........<.....<<<<
<.....<..>......>>>>><<<<<.<.<<<<....>>>>..>>>>>>.
...........<<<<<<<<<..<<<.........>>>..<<<<<<<....
.<<......>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<
..<<...<<<<<..<<....>>...>>>>>...>>..>>>>>>>>>..>>
>>><<<<<<.......>>>>>>........<...........<<<<<...
....>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>..>>>>>
>>.>>>>.>.....>.....<<<<<........>>>>>..<<<<<<<<.(
((.((......<<<<.((<<<<..<<<<<.<<<<<<<<<.<<<<.<<<<<
<.<<....>>.>>>>>>.>>>>....<<.<<<<<<.....>>>>>>>>..
...>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<..........
.>>>>>>..<....<<<<<<<...<<<<<<.......>>>>>>.....<<
.((.((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<
....>>>..>))))......<<<<<<<.((..>>>>..))>>>>>>>...
..........>>>>..))>>>>.......<<<<...<<<<<<...<<...
....>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<
<<<<......>>>>>>..>>>.<<<<.......>>>>.....>>>>>..>
...>>>.>>....<<<<<<<....>>>>>>>....))..)))>>>>>>>>
....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.
<<<<<....<<<...<<<<<<<<<<....].>>>>>..>>>>>...>>>.
.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.
......>>>>>>>..<<....>>.....<<<<<<<<.........>>>>.
...<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>
...>>>>....>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t7v Structural Basis for Linezolid Binding Site Rearrangement in theStaphylococcus aureusRibosome.
Resolution3.6 Å
Binding residue
(original residue number in PDB)
P4 R6 Y9 R11 H13 R14 T17 K22 G24 R45 Q46 S49 W65 H71 E80 V81 R82 M83 G84 A85 G86 K87 H123 K124 K128
Binding residue
(residue number reindexed from 1)
P4 R6 Y9 R11 H13 R14 T17 K22 G24 R45 Q46 S49 W65 H71 E80 V81 R82 M83 G84 A85 G86 K87 H123 K124 K128
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:5t7v, PDBe:5t7v, PDBj:5t7v
PDBsum5t7v
PubMed28487427
UniProtA0A077V4G0

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