Structure of PDB 7mqa Chain LO Binding Site BS01

Receptor Information

>7mqa Chain LO (length=819) Species: 9606 (Homo sapiens)

KFAYRFSNLLGTVYRRGNLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLP
LATRYNVKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGSVHS
VSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCID
WTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSL
DLYSLSQDGVLCMWQCDTPPEGLRLKKVKYSRLAKYFFNKEGDFNNLTAA
AFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDW
IAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDD
GKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDL
HRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLL
DVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTS
DALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKKAFTAL
CYSADGHSILAGGMSKFVCIYHVREQILMKRFEISCNLSLDAMEEFLNRR
KMTEFGNLALIDQDAGQEDGVAIPLPGVRKGDMSSRHFKPEIRVTSLRFS
PTGRCWAATTTEGLLIYSLDTRVLFDPFELDTSVTPGRVREALRQQDFTR
AILMALRLNESKLVQEALEAVPRGEIEVVTSSLPELYVEKVLEFLASSFE
VSRHLEFYLLWTHKLLMLHGQKLKSRAGTLLPVIQFLQKSIQRHLDDLSK
LCSWNHYNMQYALAVSKQR

Ligand information

>7mqa Chain L1 (length=1636)

accugguugauccugccaguagcauaugcuugucucaaagauuaagccau
gcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauu
aaaucaguuaugguuccuuuggucgcucgcuccuuacuuggauaacugug
guaauucuagagcuaauacaugccgacgggcgcugacccccggggggaug
cgugcauuuaucagaucaaaaccaacccgccccucgggcgggcgccggcg
gcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcg
gcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgcc
gugccuaccauggugaccacgggugacggggaaucaggguucgauuccgg
agagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcg
caaauuacccacucccgacccggggagguagugacgaaaaauaacaauac
aggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuu
aacgaggauccauuggagggcaagucuggugccagcagccgcgguagcuc
caauagcguauauuaaacugcaguuaaaaagcucguaguuggaucuuggg
agcgggcgggcgguccagccaccgcccguccccgccccuugccucucggc
gccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcc
ccgccuggauaccgcagcuaggaauaauggggaccgcgguucuaggaacu
gaggccaugauuaagagggacggccgggggcauucguauugcgccgcuag
aggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugc
caagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgau
cagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggc
ggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuu
ggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacg
gaagggcaccaccaggaguggagccugcggcacccggcccggacacggac
aggauugacagauugauagcucuuucucgauuccguggguuggugcaugg
ccguucguugguggagcgauuugguuaauuccgauaacgaacgagacucu
ggcaugcuagagggacaaguggcguucagccacccgagauugagcaauaa
caggucugugaugcccguccggggcacgcgcgcuacacugacuggcucag
cguguguacgccggcaggcgcgaaccccauucgugauggggaucggggau
uauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcg
uugauuaagucccugcccuuucacaccgcccgucgcuacuaccgauugga
ugguuuagugaggcccucggaucggccccgccggggucggcccacggccc
uggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaa
aguuccguaggugaaccugcggaaggaucauuaacg

..<<<<<.......>>>>>.<<.<<<<<<...<.<<.........<<<.<
<<..<<....<<....<<..........>>...>>.>>......<<....
....<<<.<....<<....<<<................<<.....<<.<<
.......>>.>>......>>.........<<<<...<<<<..>>>>...>
>>><<..<<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>
..>>...........>>>>>......>>...<<<<.<<<<......>>>>
>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.....
....>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.
>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>...
......<<<....<<<.....>>>..>>>......>>.>.....<<<<<<
<<<.<<<....>>>.>.>>>>.>>>>......<<..<...........>.
.>>.........<<<<<<.......<<<....>>>............>>>
>>>..>>>>>>.>>......<.<((.....<.<<...<<<.<<<<<.<<<
.<<<<<<<<<<<<<......>>>>>>>>>..>>>>>>>.<<<...<<<<.
<<..>>>>>>.>>>.<<<<<<.<.......<<..<<.......>>.<<<.
..>>>....>>......>.>>>..>>>.>><<.<<.<<<<<<<.>>>>>>
>.>>>>...>>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<
<<......>>>......>>>>>>>>..>>.......<<....>>...>>>
>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<..
.......>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<
<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>....
.>>>.>.>......................................<<<<
<<<<<<<<..<<..<<<<<..<<<.<<<<<<.<<<<<......<<<<<<.
......<<.<<<........>>>.>>.....>>>>>>....<<<.<<<<<
<<<<<.<<<.<<.<<....>>.<<......>>....>>.>>>....<<<.
..<...<..>..>.....<<<<<.....>>>>>........>>>....>>
>.>>.>>>>>..>>>...>>>>>>>.>>>>.>>>.....<<.<<<.....
........<<<<....>>>>......>>>.>>......<.....<<<<<.
<>.>>>>>.....>.....>>>>>.....<<<<<<<.........>>>>>
>>......>>...>>>>>>>.........>>>>>..<<<<.<<..<.<<<
<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>
>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>.>.>>.>>>>..
..<<<<<<<<<....>>>>>>>>>............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7mqa Nucleolar maturation of the human small subunit processome.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): D443 H445 R446 F450 D532 S533 W534
• Binding residue (residue number reindexed from 1): D399 H401 R402 F406 D488 S489 W490

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0031981 nuclear lumen
• GO:0032040 small-subunit processome
• GO:0034388 Pwp2p-containing subcomplex of 90S preribosome

External links

• PDB: RCSB:7mqa, PDBe:7mqa, PDBj:7mqa
• PDBsum: 7mqa
• PubMed: 34516797
• UniProt: Q15269|PWP2_HUMAN Periodic tryptophan protein 2 homolog (Gene Name=PWP2)