Structure of PDB 8pv6 Chain LN Binding Site BS01

Receptor Information
>8pv6 Chain LN (length=202) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GALKYLEELSKKKQSDVVRFLLRVRCWEYRQLNVIHRASRPSRPDKARRL
GYKAKQGYVIYRVRVRRGGRKRPVPKGATYGKPTNQGVNQLKYQRSLRAT
AEERVGRRCSNLRVLNSYWVNQDSTYKYYEVILVDPNHKAIRRDPRINWI
CNPVHKHRECRGLTSTGKKSRGLNKGHRFNKTRAGRRKTWKRHNTLSLWR
YR
Ligand information
>8pv6 Chain C1 (length=3100) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agguugaccucggaucagguaggaggacccgcugaacuuaagcauaucaa
uaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgaguga
agcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuu
ggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacg
ccacagagggugagagccccguauaguuggaagccaagccuguguaaagc
uccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaa
auuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguaga
gugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacguga
aauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucau
ccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucu
ggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauag
cccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggau
gcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagu
caagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaag
ugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauuc
ggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaac
uaugcuuggauagggugaagccagaggaaacucugguggaggcucgcagc
gguucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagac
uaaucgaaccaucuaguagcugguuaccgccgaaguuuccggauagcagu
gucgaccuucaguuuuaugagagcgaaugauuagggacucgggggcgccu
ucauccauucucuguaagaagcccuuguuacuuaacugaacgugggcgaa
ugucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggau
gaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccac
aaaaggcguuaguacaucuugacagcaggacgguggccauggaagucgga
auccgcuaaggacuguguaacaacucaccugccgaauguacuagcccuga
aaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaa
acgaugcccugaggaguaggcggccguggaggucagugacgaagccuagg
gcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagc
aaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugu
gaacagcgguuggacauggguuagucgauccuaagccauagggaaguucc
guuucaaaggggcacucgugccccgggcgaaagggaagccgguuaauauu
ccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagac
gacggcgggggccccgggcagaguucucuuuucuucuuaacggucuauca
cccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccg
acacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgg
gagggaauaauucucacgccaggucguacucauaaccgcagcaggucccc
aaggugaacagccucugguugauagaacaauguagauaagggaagucggc
aaaauagauccguaacuucgggaaaaggauuggcucuaaggguugggcac
gugcgugcgguuaacaaccaacuuagaacugguacggacagggggaaucu
gacugucuaauuaaaacauagcauugcgauggccagaaagugguguugac
gcaaugugauuucgcccagugcucuaugucaaagugaagaaauucaacca
agcgcggguaaacggcgggaguaacuaugacucucuuaagguuaacgaga
uucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgg
gcuuggcaaaaucagcggggaaagaagacccuguugagcuugacucuagu
uugacauugugaaaagacauaggagguguagaauaggugggagcuucggc
gccagugaaauaccacuacuccuauuguuuuuuuacuuauucaaugaagc
ggggcuggacuugcguccaacuucuggaguuaagguccuucgcgggccga
cccggguugaagacauugucagguggggaguuugggcacaucugcaggug
uccuaaggggggcucauggagaacagaaaucuccaguagaacaaaagggu
aaaaguccccuugauuuugauuuuugugaauacaaaccaugaaagugugg
ccccuuuagucccucgaaauuugaggcuagaggaaguuaccacagggaug
gcuuguggcggccaagcguucauagcgacgucgcuuugauccuucgaugu
cggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguac
ccacuaauagggaacgagcuggguuuagaccgucgugagacagguuaguu
uuacccuacugaugaacucgucgcaaugguaauucagcuuaguacgagag
gaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagug
ccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaa
uccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaa
uaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaag
uggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaau
ccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagagua
gccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc
...........................<<<<<<.....<......>....
..>>>>>.>...<.....<<....>>..<<<<<......<<.....>>..
...>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>.
...<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.(
(......<<<.....))>>>.>..>>..>>>.>>>..>>>>....>>>>>
>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((
((((>>>>>..>>>....>.............................<<
....>>...............<<<<....>>>>.................
.................<<<<.<<<<<<.<...<<.<<<<<<<<<.....
<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<
<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......
>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>
>>>>>>....>>>>>>>.>>>>..<<<<........>>>><<<<<<...<
<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>
>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>
>...>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<...<<<<<<....
.<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<
<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>
>......>>>>>>......>.>>...<<<<<......<<..>>..<<<<<
<<<<.....<<.<<<<<<<.........<<....<<<...<<<<<..>>>
>>.>>>..>>..>>>>>...<<<<.<<<<.<......>>>>>.>>>>.>>
>>.>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<...
...>>>...<<<<<<<...<<<(((.....<<<<<<.....<<.......
...<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>.
..>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..
........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<....
.....>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<
<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<
.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<
...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>
........<<<<<......>>>>>.>>>....>>...<<<<<........
>>>>>))<<<<.<<<<.<<<....<<<....>>>...<..{<<<<<<...
<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<
<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<
<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.
..>.....>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>
.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........
<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.<<<<
<..>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<
<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......
>>>>>>>......<<<..<<<<<<..<<<.....<<<<....>>>>....
.>>>.>>>>..>>>>><<<<<<.......>>>>>>..........>>.>>
>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<.......
.>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<
<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>
............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<
<<<..<<<<<....>>>>>..........}...<<<<<.....>>>>>..
>>>>..>>>>>.....>>>>>>>>..>>>>>...<<.<<<<<<..>>>>>
>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<....((>>
....>>>>>>>...<<<.<<<<<....>>>>.>>>>.<<<....>>>...
))<<<<<<<..<<<<.))))))>>>>>>>>>>>.>>>>..>>>>>>>...
......<<<<<<...<<.......>>...>>>>>>...............
<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<...>.
>>>.....>>>>.....>>>>......<<<<<<<....>>>.>>>>....
....>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<............
.....>>>>>.><<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>
>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...
>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.....
..<<<....>>>....>>........<<<<.....<<<.<<<<<......
.>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<
<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<
<<......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pv6 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.
Resolution2.94 Å
Binding residue
(original residue number in PDB)
G2 K5 E8 K12 K14 Q15 R20 R24 W28 R31 N34 V35 S40 R41 R44 K47 R49 R50 L51 K54 A55 K56 Q57 R67 R68 G69 G70 R71 K72 R73 P74 K77 G78 Y81 G82 K83 P84 N86 Q87 N90 Q91 K93 Y94 Q95 R96 R105 R108 S111 N112 W120 S125 Y127 K128 N138 K140 R144 R147 W150 P154 V155 H156 K157 H158 C161 R162 L164 S166 K170 S171 R172 L174 K176 G177 H178 R179 F180 N181 K182 R184 R187 R188 K189 W191 K192 R193 H194 S198 W200 R201 Y202 R203
Binding residue
(residue number reindexed from 1)
G1 K4 E7 K11 K13 Q14 R19 R23 W27 R30 N33 V34 S39 R40 R43 K46 R48 R49 L50 K53 A54 K55 Q56 R66 R67 G68 G69 R70 K71 R72 P73 K76 G77 Y80 G81 K82 P83 N85 Q86 N89 Q90 K92 Y93 Q94 R95 R104 R107 S110 N111 W119 S124 Y126 K127 N137 K139 R143 R146 W149 P153 V154 H155 K156 H157 C160 R161 L163 S165 K169 S170 R171 L173 K175 G176 H177 R178 F179 N180 K181 R183 R186 R187 K188 W190 K191 R192 H193 S197 W199 R200 Y201 R202
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8pv6, PDBe:8pv6, PDBj:8pv6
PDBsum8pv6
PubMed37921038
UniProtG0RZ88

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