Structure of PDB 7mqa Chain LM Binding Site BS01

Receptor Information
>7mqa Chain LM (length=2041) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TSLAQQLQRLALPQSDASLLSRDEVASLLFDPKEAATIDRDTAFAIGCTG
LEELLGIDPSFEQFEAPLFSQLAKTLERSVQTKAVNKQLDENISLFLIHL
SPYFLLKPAQKCLEWLIHRFHIHLYNQDSLIACVLPYHETRIFVRVIQLL
KINNSKHRWFWLLPVKQSGVPLAKGTLITHCYKDLGFMDFICSLVTKSVK
VFAEYPGSSAQLRVLLAFYASTIVSALVAAEDVSDNIIAKLFPYIQKGLK
SSLPDYRAATYMIICQISVKVTMENTFVNSLASQIIKTLTKIPSLIKDGL
SCLIVLLQRQKPESLGKKPFPHLCNVPDLITILHGISETYDVSPLLHYML
PHLVVSIIHHVTGEETEGMDGQIYKRHLEAILTKISLKNNLDHLLASLLF
EEYISYSSQEEMDSNKVSLLNEQFLPLIRLLESKYPRTLDVVLEEHLKEI
ADLKKQELFHQFVSLSTSGGKYQFLADSDTSLMLSLNHPLAPVRILAMNH
LKKIMKTSKEGVDESFIKEAVLARLGDDNIDVVLSAISAFEIFKEHFSSE
VTISNLLNLFQRAELSKNGEWYEVLKIAADILIKEEILSENDQLSNQVVV
CLLPFMVINNDDTESAEMKIAIYLSKSGICSLHPLLRGWEEALENVIKST
KPGKLIGVANQKMIELLADNINLGDPSSMLKMVEDLISVGEEESFNLKQK
VTFHVILSVLVSCCSSLKETHFPFAIRVFSLLQKKIKKLESVITAVEIPS
EWHIELMLDRGIPVELWAHYVEELNSTQRVAVEDSVFLVFSLKKFIYALK
APKSFPKGDIWWNPEQLKEDSRDYLHLLIGLFEMMLNGADAVHFRVLMKL
FIKVHLEDVFQLFKFCSVLWTYGSSLSNPLNCSVKTVLQTQALYVGCAML
SSQKTQCKHQLASISSPVVTSLLINLGSPVKEVRRAAIQCLQALSGVASP
FYLIIDHLISKAEEITSDAAYVIQDLATLFEELQREKKLKSHQKLSETLK
NLLSCVYSCPSYIAKDLMKVLQGVNGEMVLSQLLPMAEQLLEKIQKEPTA
VLKDEAMVLHLTLGKYNEFSVSLLNEDPKSLDIFIKAVHTTKELYAGMPT
IQITALEKITKPFFAAISDEKVQQKLLRMLFDLLVNCKNSHCAQTVSSVF
KGISVNAEQVRIELESYWQRVTLILELLQHKKKLRSPQILVPTLFNLLSR
CLEPLPQEQGNMEYTKQLILSCLLNICQKLSPDGGKIPKDILDEEKFNVE
LIVQCIRLSEMPQTHHHALLLLGTVAGIFPDKVLHNIMSIFTFMGANVMR
LDDTYSFQVINKTVKMVIPALIQSDVSRNVEEIVVKIISVFVDALPHVPE
HRRLPILVQLVDTLGAEKFLWILLILLFEQYVTKTVAILEADTEFWFSVC
CEFSVQHQIQSLMNILQYLLKLPEEEMLQVFNVETHTSKQLRHFKFLSVS
FMSQLLSSNNFLKKVVESGGPEILKGLEERLLETVLGYISAVAQSMERNA
DKLTVKFWRALLSKAYDLLDKVNALLPTETFIPVIRGLVGNPLPSVRRKA
LDLLNNKLQQNISWKKTIVTRFLKLVPDLLAIVQEQAINRQTALYTLKLL
CKNFGAENPDPFVPVLNTAVKLIAPERKEEKNVLGSALLCIAEVTSTLEA
LAIPQLPSLMPSLLTTMKNTSELVSSEVYLLSALAALQKVVETLPHFISP
YLEGILSQVIHLEKITSEMGSASQANIRLTSLKKTLATTLAPRVLLPAIK
KTYKQIEKNWKNHMGPFMSILQEHIGVMKKEELTSHQSQLTAFFLEALDF
VGKTENCIIDCLVAMVVKLSEVTFRPLFFKLFDWAKRLLTFYNLADCIAE
KLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSENDPEKCCLLLQFI
LNCLYKIFLFDTKERAEALMMPLVDQLENRLGGEEKFQERVTKHLIPCIA
QFSVADSLWKPLNYQILLKTRDSSPKVRFAALITVLALAEKLKENYIVLL
PESIPFLAELMEDECEEVEHQCQKTIQQLETVLGEPLQSYF
Ligand information
>7mqa Chain L2 (length=177) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacuauacuuucagggaucauaguguguuacuaaaccacgaggaagagag
guagcguuuucuccugagcgugaagccggcuuucuggcguugcuuggcug
caacugccgucagccauugaugaucguucuucucuccguauuggggagug
agagggagagaacgcggucugaguggu
..................................<<<<<.....<<....
...<<<<<<<<<<<<....<.......<<<<....<<<<<<<<......>
>>>>.>>>...>>>>.........>..<<<<<<<<<<.....>>>>>>.>
>>>>>>>>>>>>>>>...>>..>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7mqa Nucleolar maturation of the human small subunit processome.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		E1566 S1614 R1617 K1618 Q1663 A1664 I1665 E1707 S1752
Binding residue
(residue number reindexed from 1)		E1497 S1545 R1548 K1549 Q1586 A1587 I1588 E1630 S1675
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030515 snoRNA binding
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0016072 rRNA metabolic process
GO:0042254 ribosome biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0061351 neural precursor cell proliferation
GO:1902570 protein localization to nucleolus
GO:2000234 positive regulation of rRNA processing
Cellular Component
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:0034455 t-UTP complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7mqa, PDBe:7mqa, PDBj:7mqa
PDBsum7mqa
PubMed34516797
UniProtQ9H583|HEAT1_HUMAN HEAT repeat-containing protein 1 (Gene Name=HEATR1)

[Back to BioLiP]