Structure of PDB 5t7v Chain LM Binding Site BS01

Receptor Information
>5t7v Chain LM (length=143) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RQTFMANESNIERKWYVIDAEGQTLGRLSSEVASILRGKNKVTYTPHVDT
GDYVIVINASKIEFTGNKETDKVYYRHSNHPGGIKSITAGELRRTNPERL
IENSIKGMLPSTRLGEKQGKKLFVYGGAEHPHAAQQPENYELR
Ligand information
>5t7v Chain B (length=2768) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gauuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgau
gaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuu
gauccagagauuuccgaauggggaaacccagcaugaguuaugucauguua
ucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaa
caucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcg
gcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguug
uaggacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaa
agaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucu
ugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugg
gaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaacca
guaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaa
ccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggc
gugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaag
caguaaauguggagccguagcgaaagcgagucugaauagggcguuuagua
uuuggucguagacccgaaaccaggugaucuacccuuggucagguugaagu
ucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagc
ggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcug
guucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggag
guagagcacuguuuggucagacaaacuccgaaugccaauuaauuuaacuu
gggagucagaacaugggugauaagguccguguucgaaagggaaacagccc
agaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugg
cguugcccagacaacuggagugcguaauagcucacuagucgagugacacu
gcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguc
cuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucgua
aggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaag
acgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcu
cguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggc
gauggauaacagguugauauuccuguaccaccuauaaucguaucgauggg
gggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagca
guaaggcugaguaauccgguacucgggcugagcugugauggggagaagac
auugugucuucgagucguugauuucacacugccgagaaaagccucuagau
agaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaa
uucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccc
cguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagcc
gcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcua
aaccguaaggugauguauaggggcugacgccugcccagugcuggaagguu
aagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaac
ggcggccguaacuauaacgguccuaagguagcgaaauuccuugucgggua
aguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgag
agacucggugaaaucauaguaccugugaagaugcagguuacccgcgacag
gacggaaagaccccguggagcuuuacuguagccugauauugaaauucggc
acagcuagcuguguuggcuuucuaacccgcaccacuuaucguggugggag
acagugucaggcgggcaguuugacuggggcggucgccuccuaaaagguaa
cggaggcgcucaaagguucccucagaaugguuggaaaucauucauagagu
guaaaggcauaagggagcuugacugcgagaccuacaagucgagcaggguc
gaaagacggacuuagugauccggugguuccgcauggaagggccaucgcuc
aacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguu
cacaucgacggggagguuuggcaccucgaugucggcucaucgcauccugg
ggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacg
cgagcuggguucagaacgucgugagacguucggucccuauccgucguggg
cguaggaaauuugagaggagcuguccuuaguacgagaggaccgggaugga
cauaccucugguguaccaguugucgugccaacggcauagcuggguagcua
uguguggacgggauaagugcugaaagcaucuaagcaugaagccccccuca
agaugagauuucccaacuucgguuauaagaucccucaaagaugaugaggu
uaauagguucgagguggaagcauggugacauguggagcugacgaauacua
aucgaucgaagacuuaau
..<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<...
...<<.<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>...
..>>>>>>>....>>....<<<....>>>.<<<<<<......>>>>>>..
<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<...
...>.......>>>>.>.........<<....>>..<<<<<......<<.
....>>.....>>>>>..(((....<<<<<..........>>>>>.....
.<<<<<<<<<...<.........<<<..<<<<<.<<<...<<<<<.....
.>>>>>((......<<<.....))>>>...>>>.>..>>>>..>>>...>
.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<
<<<..<<<<>>>>>..)))......]].>>>>>>>.]]............
...<<....>>....]].........<<<......>>>............
.}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>
...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<
<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>
>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<
<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>
>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>
>..<<<<<<....<<<<<....>>>>><<.<<<<<<...<<<<<<<<<..
....<<...<<<<<<..>>>>>>..>>.......>>>>.>>>>>..>>>>
>>..>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>
...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<
.<<<<........<<<.....<<......>>.....>>>....>>>>.>>
>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<
.....>>>>>>....>>>>>>..<<<<<<<.<.......<<<<<.<<...
.>>.>>>>>....>.>>>>>>>........>>>>>><......<.....<
<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<..
...>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>
..>>>....<<<<........>>>>.))<<<<<<<......<<<...<<<
<....<<<<...<<...<.......<<...[.....>>....<....<<<
<...<<<...................>>>...>>>>.....>.....<..
.........>........>....>>...>>>.>........>>>>..>>>
.....>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<......
.>>>..>>>>..<<<<....<<<<<<<..<<.........<.....<<<<
<.....<..>......>>>>><<<<<.<.<<<<....>>>>..>>>>>>.
...........<<<<<<<<<..<<<.........>>>..<<<<<<<....
.<<......>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<
..<<...<<<<<..<<....>>...>>>>>...>>..>>>>>>>>>..>>
>>><<<<<<.......>>>>>>........<...........<<<<<...
....>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>..>>>>>
>>.>>>>.>.....>.....<<<<<........>>>>>..<<<<<<<<.(
((.((......<<<<.((<<<<..<<<<<.<<<<<<<<<.<<<<.<<<<<
<.<<....>>.>>>>>>.>>>>....<<.<<<<<<.....>>>>>>>>..
...>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<..........
.>>>>>>..<....<<<<<<<...<<<<<<.......>>>>>>.....<<
.((.((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<
....>>>..>))))......<<<<<<<.((..>>>>..))>>>>>>>...
..........>>>>..))>>>>.......<<<<...<<<<<<...<<...
....>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<
<<<<......>>>>>>..>>>.<<<<.......>>>>.....>>>>>..>
...>>>.>>....<<<<<<<....>>>>>>>....))..)))>>>>>>>>
....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.
<<<<<....<<<...<<<<<<<<<<....].>>>>>..>>>>>...>>>.
.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.
......>>>>>>>..<<....>>.....<<<<<<<<.........>>>>.
...<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>
...>>>>....>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t7v Structural Basis for Linezolid Binding Site Rearrangement in theStaphylococcus aureusRibosome.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		R2 N8 E9 G27 R28 S31 S35 R38 K40 H48 T66 K69 Y76 H78 S79 G83 K86 G108 M109 P111 S112 R114 L115 K121 H133 A135 Q136
Binding residue
(residue number reindexed from 1)		R1 N7 E8 G26 R27 S30 S34 R37 K39 H47 T65 K68 Y75 H77 S78 G82 K85 G107 M108 P110 S111 R113 L114 K120 H132 A134 Q135
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0017148 negative regulation of translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5t7v, PDBe:5t7v, PDBj:5t7v
PDBsum5t7v
PubMed28487427
UniProtW8TUE6

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