Structure of PDB 8rxh Chain LK Binding Site BS01

Receptor Information
>8rxh Chain LK (length=169) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSHYICAGRLVRILRGPRQDRVGVIVDIVDANRVLVENPEDAKMWRHVQN
LKNVEPLKYCVSVSRNCSAKALKDALASSKALEKYAKTRTAARVEAKKAC
AVSTDFERYQLRVARRSRAHWARKVFDEKDAKTPVSWHKVALKKMLKKAA
KMDSTEGAKRRMQKAIAAR
Ligand information
>8rxh Chain L1 (length=1677) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacucag
cggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaaga
gggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggc
acaaauaucauugugugguuggugcaggaguggcgaaauucaagcgaaaa
gcaaacccguugcugaauacaacccuucaugugaguauugagccaaagaa
gguguuagcccauugagccauaaaccugagcgccucaugaauaagcgagu
agcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaa
guuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaa
guuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugac
aaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugc
auuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaucu
ugggucuuggugaaaugagcggaguauuugagcugcgcacggcgcgccgc
acgcacugguuucuucuccgugaugcuccauguuggcgauggaaaugggg
ugcccccacccgucuugaaacacggaccaaggagucaaacagacgcgcaa
gggaggagauaugguugccaguacuucucucguacugaaagggagaugca
aaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacac
cgaccggcccuccguggguugcguuggagugugccuguuuggacccgaaa
gguggugaacuaugccugaacaaggugaagcccggggaaacccaggugga
ggccuguagcgaugcugacgugcaaaucgcucguaugauuuggguaucgg
agcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucc
cucaggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauu
agaggucgaccuauucucaaacuuuaaaugugcaaacaaaccgugccuua
gccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuu
cuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggauaugug
gcgucaaaacuuaugggcucauucucgauacgugaaaaggguguuggugg
auacaguuggacccaaccgaauccaccggccccgaaaauggaugacgcuu
aagcccaauuagugauugcccauuauuccuuugguaagggcggaaacaaa
uggagaaaguguagcccuuccgauguagauguggccuggagguuaggacg
aagcuuauggcgugagccuaagauggaccggccucuagugcagaucuugg
uuggcguagcaaagaucuaacggagauauacucaacaugcaacguuggau
acuggagcggggaaggauuucgugccaacggcacucguacacgaguuguu
cggaaacugagcacaacguuauaucguuuuguuaggaaagugaaggugug
ucggcggagcuguucgacugugaaaaggggcaacagagaaccugggauua
uauuccaaaaagaaauugcauguggga
.......................<<<<<......<......>.......>
>>>.>.........<<....>>..<<<<<<......<<.....>>....>
>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>
>............<<<<...<<<<<<<<.<<<<<......<<<......<
<<<.......>>>>.....<<........>>......>>>.<<.......
((.....>>)).....>>>>>...>>>..>>>>>.>>>>...........
.<<<<<<<........>>>>>>>......<<<<<........>>>>>..>
>>....................................<<....>>....
............<<<<....>>>>..........................
........<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<
<<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>........
.>>>>..>>>>........<<<<<.....<<<<<..<<.<<<<..>>>>.
..>>...>>>.>>..>>>>>.....<<<<...>>>>>>....>>>>>>>>
>>>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..
<<<..<<<.<............>>>>..>>>...<<....>>..<<<<<.
....>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>
><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<..<
<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>...
..>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...
<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<
....>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<<..
..<<<....>>>....>>>..>.>>...>>>>>>>.....<<<.<<<<<.
<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.
<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<
<<(((......<..<<<<........<...........<<<.<<<<<<<<
<<..................>>>>>>>>>>>>>..........))).>..
..>>>>.>.........>>>...>>>>>>><<<<.<<<<<..........
.>>>>.........>>>>>>>>>....>>>>>....<<<<<<<<......
...<<<..<<<....>>>.>>>.......>>>>>>>>........>>>>>
>..............<<<<<<<....................>>>>>>>.
...................<<<<<....<<.....>>..>>>>>....<<
..........<<.<<<<<......>>>>............<..<.<..<<
.....<...>....>>..>.>..>...>.>>..........<<<<.....
....>>....>>.>>............
Receptor-Ligand Complex Structure
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PDB8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		R17 G18 P19 R20 N34 K45 W47 H49 V50 N55 N68
Binding residue
(residue number reindexed from 1)		R15 G16 P17 R18 N32 K43 W45 H47 V48 N53 N66
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum8rxh
PubMed38722744
UniProtQ4QBJ1

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