Structure of PDB 7mqa Chain LH Binding Site BS01

Receptor Information
>7mqa Chain LH (length=746) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRVVRCGGSELNFRRAVFSADSKYIFCVSGDFVKVYSTVTEECVHILHGH
RNLVTGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALF
TLAQAEDSVFVIVNKEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQ
SPKCIAFGNEGVYVAAVREFYLSVYFFKKKTTSRFTLSSSRNKKHAKNNF
TCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYTYTCLHWHHDMVMDLAF
SVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSPAGDLFC
TSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPG
HLQFYSLQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVE
QRQEKETELELQMKLWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKS
EQPTLVTASKDGYFKVWILTDDSDIYKKAVGWTCDFVGSYHKYQATNCCF
SEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAGKIRHLCFGRLTCSKYL
LGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQSSVGSD
LFVFKPSEPRPLYIQKGISREKVQWGVFVPRDVPESFTSEAYQWLNRSQF
YFLTKSQSLLTFSTKTTPFYFILGKHRNELVQLPLTENIPAISELLHTPA
HVLPSAAFLCSMFVNSLLLSKDIIHQLSKSEEKELRKFRKIDYSWI
Ligand information
Receptor-Ligand Complex Structure
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PDB7mqa Nucleolar maturation of the human small subunit processome.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		K200 H201 K237 Y239 Y241 C243 H245 W246 H247 H248 E280 F285 P287 R288 D382
Binding residue
(residue number reindexed from 1)		K194 H195 K231 Y233 Y235 C237 H239 W240 H241 H242 E274 F279 P281 R282 D376
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:2000234 positive regulation of rRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0032040 small-subunit processome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7mqa, PDBe:7mqa, PDBj:7mqa
PDBsum7mqa
PubMed34516797
UniProtQ8IWA0|WDR75_HUMAN WD repeat-containing protein 75 (Gene Name=WDR75)

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