Structure of PDB 5tcu Chain LG Binding Site BS01

Receptor Information
>5tcu Chain LG (length=43) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKRTYQPNKRKHSKVHGFRKRMSTKNGRKVLARRRRKGRKVLS
Ligand information
>5tcu Chain B (length=2755) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccaauga
aggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuuga
uccagagauuuccgaauggggaaacccagcaugaguuaugucauguuauc
gauaugugaauacauagcauaucagaaggcacacccggagaacugaaaca
ucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggc
gagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguugua
ggacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaaag
augaaucaaagaagguaauaauccuguagucgaaaauguugucucucuug
aguggauccugaguacgacggagcacgugaaauuccgucggaaucuggga
ggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccagu
accgugagggaaaggugaaaagcaccccggaaggggagugaaauagaacc
ugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgu
gccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagca
guaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauu
uggucguagacccgaaaccaggugaucuacccuuggucagguugaaguuc
agguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcgg
augaacugaggguagcggagaaauuccaaucgaaccuggagauagcuggu
ucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggaggu
agagcacuguuuggacgaggccgaauucagacaaacuccgaaugccaauu
aauuuaacuugggagucagaacaugggugauaagguccguguucgaaagg
gaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaa
aaggauguggcguugcccagacaacuaguagucgagugacacugcgccga
aaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuugga
caaugguaggagagcguucuaagggcguugaagcaugaucguaaggacau
guggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggug
agaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgc
ucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggau
aacagguugauauuccuguaccaccuauaaucgaucgauggggggacgca
guaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcu
gaguaauccgguacucgggcugagcugugauggggagaagacucuucgag
ucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcc
cguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcg
agcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggag
aaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcc
caagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugau
guauaggggcugacgccugcccggugcuggaagguuaagaggagugguua
gcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaacua
uaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgca
cgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaau
cauaguaccugugaagaugcagguuacccgcgacaggacggaaagacccc
guggagcuuuacuguagccugauauugaaauucggcacagcuagcugugu
uggcuuucuaacccgcaccacuuaucguggugggagacagugucaagcgg
gcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaa
gguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagg
gagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuua
gugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcu
accccggggauaacaggcuuaucucccccaagaguucacaucgacgggga
gguuuggcaccucgaugucggcucaucgcauccuggggcuguagucgguc
ccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucag
aacgucgugagacaguucggucccuauccgucgugggcguaggaaauuug
agaggagcuguccuuaguacgagaggaccgggauggacauaccucuggug
uaccaguugucgugccaacggcauagcuggguagcuauguguggacggga
uaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucc
caacuucgguuauaagaucccucaaagaugaugagguuaauagguucgag
guggaagcauggugacauguggagcugacgaauacuaaucgaucgaagac
uuaau
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.>.......>>>>.>.........<<....>>...<<<<......<<...
..>>.....>>>>...(((....<<<<<<<<....>>>>>>>>.......
<<<<<<<<...<.<........<..<<<<<<.<<<...<<<<<......>
>>>>((......<<<.....))>>>...>>>...>>>>>>...>.>.>.>
>>>>..>>>......<<<<<<<<.........>>>>>>>>......<<<<
<..<<<<>>>>>..)))......]].>>>>>>>.]]..............
.<<....>>....]].........<<<<....>>>>..............
....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>..
.<.<........>.>.<<<<<<....<<<<<<<.<<<<...<<<...<<<
.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>
.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<
<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>
....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>.
.<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<....
.<<<...<<<<<<<<..........>>>>>>>>..>>.>.....>>>>.>
>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<
<......>>>...<<<<.<<<...<<<(((.....<<<<<<.........
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.........))).....>>>>>>.>>>...>>>>>>><<<<<<.....>>
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>>...>>.>>>>>>>........>>>>>><......<.....<<<<<<..
.....>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>
>>>>>.....(<<<<.<<...<<<...<<<....>>>...>>>...>>..
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..................>>>..>>>>>.....>................
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..>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<
<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>...
....>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.
.<....>...>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>.....
>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<
<.[.<<<<..<<<<<.<<.<<<<<<.<<<<.<<<<<<<<<<..>>>>>>>
>>>.>>>>....<<.<<<<<.......>>>>>>>.....>>>>>>.>>..
>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...
<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>
>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]
......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>
...]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>
>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>
>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<
<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<..
.<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<.
..<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<.
<..<<<<.............>>>>...>>>>.>>>>.......>>>>>>>
.<<......>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<
<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>
>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5tcu Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.
Resolution3.9 Å
Binding residue
(original residue number in PDB)
K3 R4 T5 Y6 Q7 P8 N9 K10 R11 K12 H13 S14 K15 V16 H17 G18 F19 R20 R22 K26 N27 R34 R35 R37 K38 R40
Binding residue
(residue number reindexed from 1)
K2 R3 T4 Y5 Q6 P7 N8 K9 R10 K11 H12 S13 K14 V15 H16 G17 F18 R19 R21 K25 N26 R33 R34 R36 K37 R39
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5tcu, PDBe:5tcu, PDBj:5tcu
PDBsum5tcu
PubMed28487427
UniProtQ2FUQ0|RL34_STAA8 Large ribosomal subunit protein bL34 (Gene Name=rpmH)

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