Structure of PDB 8rxx Chain LF Binding Site BS01

Receptor Information
>8rxx Chain LF (length=149) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVSRKSPEYTTLRKSCAPGAIAIILAGRFRGRRAVILKQLPHNGPLVVSG
PMKYNGVPIRRIDSRYVIATSTTVDISSVDTAPITAEVFQRPKAEKPTLV
SDARAQLQKKIDAALIAAIKKDAQGKEKAGYLRSVFTVKPGDAPHRWNW
Ligand information
>8rxx Chain L1 (length=1657) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucauugugugguuggugcaggaguggcgaaauucaagcgaaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacaagcgagua
gcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaag
uuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaag
uuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugaca
aagacaauggaaguaccuccauuucaacggccagaaccagcccuacugca
uuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaucuu
gggucuuggugaaaugagcggaguauuugagcugcgcacggcggccgcac
gcacugguuucuucuccgugaugcuccauguuggcgauggaaauggggug
cccccacccgucuugaaacacggaccaaggagucaaacagacgcgcaagg
gaggagauaugguugccaguacuucucucguacugaaagggagaugcaaa
augcaucuguggugugcacacgucaaauccguuugauuugcccaacaccg
accggcccuccguggguugcguuggagugugccuguuuggacccgaaagg
uggugaacuaugccugaacaaggugaagcccggggaaacccagguggagg
ccuguagcgaugcugacgugcaaaucgcucguaugauuuggguaucggag
cgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucccu
caggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauuag
agggaccuauucucaaacuuuaaaugugcaaacaaaccgugccuuagcca
acugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuuc
gguaagcggagcaggcgaugcggaaugaaccgcuuagggauauguggcgu
caaaacuuaugggcucauucucgauacgugaaaaggguguugguggauaa
auccaccggccccgaaaauggaugacgcuuaagcccaauuagugauugcc
cauuauuccuuugguaagggcggaaacaaauggagaaaguguagcccuuc
cgauguagauguggccuggagguuaggacgaagcuuauggcgugagccua
agauggaccggccucuagugcagaucuugguuggcguagcaaagaucuaa
cggagauauacucaacaugcaacguuggauacuggagcggggaaggauuu
cgugccaacggcacucguacacgaguuguucggaaacugagcacaacguu
auaucguuuuguuaggaaagugaaggugugucggcggagcuguucgacug
ugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugca
uguggga
......................<<<<<......<......>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
............<<<<...<<<<<<<<.<<<<<......<<<......<<
<<.......>>>>.....<<........>>......>>>.<<.......(
(.....>>)).....>>>>>...>>>..>>>>>.>>>>............
<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>
>....................................<<....>>.....
...........<<<<....>>>>...........................
.......<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<
<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>.........
>>>>..>>>>........<<<<<.....<<<<<<.<<.<<<<.>>>>...
>>.>.>>>.>>..>>>>>.....<<<<...>>>>>>....>>>>>>>>>>
>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..<<
<..<<<.<............>>>>..>>>...<<....>>..<<<<<...
..>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><
<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<...<<
<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....
>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<
.......>>......>>>>>>......>.>>...<<<<<....<.<<<..
..>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<...<.
<<<..>>>.>...>>..>>.>...>>>>>>>.....<<<.<<<<<.<<..
...>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<
<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<((
(......<..<<<<........<...........<<<.<<<<<<<<<<..
>>>>>>>>>>>>>..........))).>....>>>>.>.........>>>
...>>>>>>><<<<.<<<<<...........>>>>.........>>>>>>
>>>....>>>>>....<<<<<<<<.........<<<..<<<....>>>.>
>>.......>>>>>>>>........>>>>>>..............<<<<<
<<....................>>>>>>>....................<
<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<..
....>>>>............<.......<<...<......>...>>....
.>.....>.>>..........<<<<.........>>....>>.>>.....
.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		R21 T27 T28 L29 N60 D80 R82 Y83 K110 K113 P114
Binding residue
(residue number reindexed from 1)		R4 T10 T11 L12 N43 D63 R65 Y66 K93 K96 P97
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
PDBsum8rxx
PubMed38722744
UniProtQ4Q4D3

[Back to BioLiP]