Structure of PDB 8pv3 Chain LC Binding Site BS01

Receptor Information
>8pv3 Chain LC (length=363) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRPTVTVFGADGKPTGATEVLPKVFSAPIRPDIVKHVHTGMAKNKRQPYA
VSEKAGHQTSAESWGTGRAVARIPRVSGGGTHRAGQGAFGNMCRSGRMFA
PTKIWRKWHVKINQGQKRFATASALAASAVAPLLMARGHQVSTVPEVPLV
VDSAAVAGDAVAKTAAAYKLLKAIGAGPDVEKVKKSKKLRAGKGKMRGRR
HRQRRGPLIVYSPEHDGKELVKGFRNIPGVETCPVDALNLLQLAPGGHLG
RFIVWTSAAIKQLDAVYESKKGFFLPANIVSQADLSRLINSTEIQSVLRA
PKGEARTKRACVQKKNPLRNKQIMLRLNPYASTFAKEKLGEVKAEEGKPP
KVPASFKELLHEA
Ligand information
>8pv3 Chain C1 (length=2998) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agguugaccucggaucagguaggaggacccgcugaacuuaagcauaucaa
uaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgaguga
agcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuu
ggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacg
ccacagagggugagagccccguauaguuggaagccaagccuguguaaagc
uccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaa
auuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguaga
gugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacguga
aauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucau
ccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucu
ggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauag
cccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggau
gcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagu
caagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaag
ugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauuc
ggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaac
uaugcuuggauagggugaagccagaggaaacucugguggaggcucgcagc
gguucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagac
uaaucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauag
cagugucgaccuucaguuuuaugagguaaagcgaaugaacuuuaaauaug
uaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgaca
cuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaa
cgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcg
uuaguacaucuugacagcaggacgguggccauggaagucggaauccgcua
aggacuguguaacaacucaccugccgaauguacuagcccugaaaauggau
ggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcc
cugaggaguaggcggccguggaggucagugacgaagccuagggcgugagc
ccgggucgaacggccucuagugcagaucuuggugguaguagcaaauacuu
caaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagcg
guuggacauggguuagucgauccuaagccauagggaaguuccguuucaaa
ggggcacucgugccccguguggcgaaagggaagccgguuaauauuccggc
accuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacgg
cgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccug
gaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacu
ucugucggguccggugcgcucucgacgucccuugaaaauccgcgggaggg
aauaauucucacgccaggucguacucauaaccgcagcagguccccaaggu
gaacagccucugguugauagaacaauguagauaagggaagucggcaaaau
agauccguaacuucgggaaaaggauuggcucuaaggguugggcacgugcg
ugcgguuaacaaccaacuuagaacugguacggacagggggaaucugacug
ucuaauuaaaacauagcauugcgauggccagaaagugguguugacgcaau
gugauuucguagccaaauggauuaacgagauucccacugucccuaucuac
uaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcgggg
aaagaagacccuguugagcuugacucuaguuugacauugugaaaauuuuu
acuuauucaaugaagcggggcuggacuugcguccaacuucuggaguuaag
guccuucgcgggccgacccggguugaagacauugucagguggggaguuug
gcuggggcggcacaucugugcagguguccuaaggggggcucauggagaac
agaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuu
cagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccu
cgaaauuugaggcuagaggugccagaaaaguuaccacagggauggcuugu
ggcggccaagcguucauagcgacgucgcuuugauccuucgaugucggcuc
uuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccac
uaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuu
acccuacugaugaacucgucgcaaugguaauucagcuuaguacgagagga
accgcugauucagauaauugguuuuugcgguuguccgaccgggcagugcc
gcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauc
caugccagaacgcgacgauacuacccgcacguuguagacguauaagaaua
ggcuccggccucguauccuagcaggcgauuccuccgccggccucgaagug
gccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaaucc
uuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagc
cuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc
...........................<<<<<<.....<...<..>....
..>>>>>.>...[.....<<....>>..<<<<<......<<.>...>>..
...>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>.
...<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.(
(......<<<.....))>>>.>..>>..>>.>>>>..>>>>....>>>>>
>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((
((((>>>>>..>>>....].............................<<
....>>...............<<<<....>>>>.................
.................<<<<.<<<<<<.<...<<.<<<<<<<<<.....
<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<
<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......
>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>
>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<
<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>
>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>
>...>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<...<<<<<<....
.<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<
<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>
>......>>>>>>......>.>>...<<<<<......<<<....>>>..<
<<<<<<<<.....<<.<<<<<<<.....<<<........>>.>.....>>
>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>
>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>..
.<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<
<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>...
......<<......>>...>>>>>...>>>>>>>>>>>>>..........
))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>
>>>>>>....>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>
>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<
<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<...
..>>.>>>>>>....((<<<<<<...<<<<..<<<....>>>........
<<<<<......>>>>>...>>>>....>>...<<<<<........>>>>>
))<<<<.<<<<.<<<....<<<....>>>...<.{.<<<<<<...<<<<.
<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<<<<<<
....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<...
...>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>..
...>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<
.....>>>>..>>>>..<<<<.....<<<<<<<.<<..............
.<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.<<<<<..>>
>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<
<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>
>>...........<<..>>......>>.>>>>>>>.....>>.>>>>>>>
..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<
........<<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<..>>>>
>>...<<<<<.....<<<<..<<<<<....>>>>>...........}..<
<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...
....<<<<<<.<<<<<<....>>>>>>>>...<<<<<<<...<<<<<<..
.....>>>>>>.....<<......>>....>>>>>>>....<<<<.<.<<
<.....>>>.>>>>>.<<<....>>>..>>>>.<<...<<<<<<<..<<<
<.))))))>>>>>>>>>>>.....>>..>>>>..>>>>>>>.........
<<<<<<...<<.......>>...>>>>>>...............<<<<..
.<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.
....>>>>.......>>>>......<<<<<<<....>>>.>>>>......
..>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<..............
...>>>>>.><<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>
>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>
>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......
<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>
>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<
<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<
......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pv3 Structural insights into coordinating 5S RNP rotation with ITS2 pre-RNA processing during ribosome formation.
Resolution2.8 Å
Binding residue
(original residue number in PDB)
R32 I35 H38 T41 A44 K45 N46 K47 R48 Q49 Y51 V53 S54 A57 H59 Q60 T61 S62 T68 G69 R70 V72 A73 R74 I75 P76 G81 G82 T83 H84 R85 Q88 N93 M94 R96 S97 R99 M100 F101 A102 P103 K105 W107 R108 K109 K113 I114 N115 Q116 Q118 K119 R120 R139 Q142 K165 T166 K187 K190 L191 R192 A193 G194 K195 K197 M198 R199 R201 R204 R206 R207 Y213 K220 V223 K224 R227 N228 T234 D238 N241 P247 G248 H250 K272 K273 S288 I291 N292 T294 Q297 P303 K304 G305 E306 R308 T309 K310 R311 A312 V314 Q315 K317 R321 N322 K323 Q324 R328 E343 V344 K345 E348 G349 K350 P351 V354 F358 L362 H363
Binding residue
(residue number reindexed from 1)
R30 I33 H36 T39 A42 K43 N44 K45 R46 Q47 Y49 V51 S52 A55 H57 Q58 T59 S60 T66 G67 R68 V70 A71 R72 I73 P74 G79 G80 T81 H82 R83 Q86 N91 M92 R94 S95 R97 M98 F99 A100 P101 K103 W105 R106 K107 K111 I112 N113 Q114 Q116 K117 R118 R137 Q140 K163 T164 K185 K188 L189 R190 A191 G192 K193 K195 M196 R197 R199 R202 R204 R205 Y211 K218 V221 K222 R225 N226 T232 D236 N239 P245 G246 H248 K270 K271 S286 I289 N290 T292 Q295 P301 K302 G303 E304 R306 T307 K308 R309 A310 V312 Q313 K315 R319 N320 K321 Q322 R326 E341 V342 K343 E346 G347 K348 P349 V352 F356 L360 H361
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8pv3, PDBe:8pv3, PDBj:8pv3
PDBsum8pv3
PubMed37921038
UniProtG0SFC3

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