Structure of PDB 8ia0 Chain LC Binding Site BS01 |
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| >8ia0 Chain C1 (length=2928)
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uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagc
ggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugga
gaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcca
cagagggugagagccccguauaguuggaagccaagccuguguaaagcucc
uucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauu
ucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagug
aucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaau
uguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccg
guguucucaccggugcacuccgccgggcucaggccagcaucgguucuggc
ggggggauaaaggcccagggaauguggcuccuccgggaguguuauagccc
uggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcu
ggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaa
gguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagc
uucggcgcaucaucgaccgauccugauguauucggauggauuugaguagg
agcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggug
aagccagaggaaacucugguggaggcucgcugacgugcaagaucgucaaa
ucugagcaugggggcgaaagacuaaccaucuaguagcugguuaccgccga
aguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcg
aaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggu
cgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaug
cgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucaga
caccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaa
gucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuag
cccugaaaauggauggcgcucaagcgucccacccauaccccgcccucagg
guagaaacgaugcccugaggaguaggcggccguggaggucagugacgaag
ccuagggcgugagcccgggucgaacggccucuagugcagaucuugguggu
aguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguu
ccaugugaacagcgguuggacauggguuagucgauccuaagccauaggga
aguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccg
guuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaa
cgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaac
ggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccgg
aagagcccgacacuucugucggguccggugcgcucucgacgucccuugaa
aauccgcgggagggaauaauucucacgccaggucguacucauaaccgcag
cagguccccaaggugaacagccucugguugauagaacaauguagauaagg
gaagucggcauccguaacuucgggaaaagggcucuaaggguugggcacgu
ugggcuuugggcggacgcccugggagcagagggccucuagccgggcaacc
ggccggcggcccucagcacccgggguugaagcccuuagcccggcgugcgg
uuaacaaccaacuuagaacugguacggacagggaaucugacgucuauagc
auugcgauggccagaaagugguguugacgcaaugugucugcccagugcuc
ugaaugucaaagugaagaaauucaaccaagcgcggguaaaaugccucguc
aucuaauuagugacgcgcauggauaacgagauucccacugucccuaucua
cuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggg
gaagacccuguugagcuugacucuaguuugacauugugaaaagacauagg
agguguagaauaggugggagcuucggcgccagugaaauaccacuacuccu
auuguuuuuuuacuuauucaaugugaagacauugucagguggggaguucc
uuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggaua
acuggcuuguggcggccaagcguagcgacgucgcuucggcucuuccuauc
auaccgaagcagaauucgguaagcguuggauuguucacccacuaauaggg
aaagcuggggaccgucgugagacagguuagucccuacugaugaacucguc
gcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauug
guuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcugg
auaauggcugaacgccucuaagucagaauccaugccagaacgcgacgaua
cuacccgcacguuguagacguauaagaauaggcuccggccucguauccua
gcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguau
ugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugu
gcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcug
aggguaagcccuccuucgccuagauuuc |
........................<<<<<<.....<<....>>......>
>>>>.>.........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....
<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((..
....<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>
.>>........<<<<<<<........>>>>>>>.....<<<<<<......
>>>>>>..>>>..................................<<...
.>>...............<<<<....>>>>....................
..............<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<
<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<
<<<<<.....<.<<<<<<<<......<<<<<<..>>>>>>.......>>>
>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>
>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<....<<<
<<<<<.<<<<..<<<...<<<<.....>>>>...>>>....<<<<<..<<
....>>...>>>>>.<<<<<<<<..............>>>.>>>.>>...
.>>>>.>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<.
..<<<<<<<....>>>>>>>....>>>>..<<<<<........>>>>>..
>>>>>>>>>..<<.<....>.>>.>>>>>>......>.>>...<<<<<..
..<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<..
......>>.>.....>>>>>....<<<.<<<<.<......>>>>>.>>>.
..>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....
<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<.
.........<<<.<<<<<<<<<<.......<<<<<.<<<...<<......
...>>...>>>.........<<......>>...>>>>>...>>>>>>>>>
>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<
<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<
<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.
....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...
<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<.
...>>>........<<<<<......>>>>>....>>>....>>...<<<<
<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......
<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<...((..>>>>.><...<
<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.
...><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.......
..>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<....
..>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<
.......<..<<<<<<.<.<<.................<<<<<.<<<<<.
.<.<<<..<<<<....<<<<<<<<.<<.<<<<<<<.<<.<<<<<....>>
>>>.>>.>>>>>>>.>>.>>>>>>>>....>>>>..>>>>...>>>>>..
....>>>>>......>>...>.>>>>>>..<<<<<<<<<..<<<<...<<
<<<<<....<<<<.....>>>>......>>>>>>>...<<<<<.<<<<<.
<<<<<.<<........>>.>>>>>....>>>>>>>>>>..<<<<..<<<<
<<.......>>>>>>.>>>>>>>>..>>.>>>>>>>.>...>>.>>>>>>
>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<
<....<<<<<<.<<<<<<.<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<
<<..........<<<<<..<<....>>............>>>>>.>>>>>
>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>>..>>>>>.<<
<<<<<..<<<<<.....>>>>>>>>>>>>....>>>>>.>.>>>>>>...
..........<<<<<<...<<...>>...>>>>>><<<<<<.<<<<<..<
.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>
>.>>>>>>.<<<<<<<....>>>.>>>>....>>>.>>>>>....<<<<<
<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<
<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..>>>>>.<<<
<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>..
...<<<<<.<<.<<<......<<.......<<<....>>>....>>....
....<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>....
..........>>>>>.>>>>>...<<<<<<<.............>>....
<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>..
.>>>....>>>>..>>>>>...>>>>>. |
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| PDB | 8ia0 Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis. |
| Resolution | 2.7 Å |
Binding residue
(original residue number in PDB) | R32 K37 H38 T41 M43 K45 N46 K47 R48 Q49 Y51 V53 S54 A57 H59 Q60 T61 S62 R70 A71 V72 A73 R74 P76 G82 T83 R85 Q88 N93 M94 R96 S97 R99 M100 F101 A102 P103 K105 W107 R108 K109 K113 N115 Q116 Q118 K119 R120 R139 Q142 T166 K186 K190 L191 R192 A193 G194 K195 M198 R199 R201 R206 R207 Y213 V223 K224 R227 N228 T234 A239 L240 N241 P247 G248 H250 K272 K273 F276 S288 I291 N292 T294 Q297 P303 K304 G305 E306 T309 K310 R311 A312 V314 Q315 K317 R321 N322 K323 Q324 R328 G342 E343 E348 G349 K350 P351 V354 L362 H363 |
Binding residue
(residue number reindexed from 1) | R29 K34 H35 T38 M40 K42 N43 K44 R45 Q46 Y48 V50 S51 A54 H56 Q57 T58 S59 R67 A68 V69 A70 R71 P73 G79 T80 R82 Q85 N90 M91 R93 S94 R96 M97 F98 A99 P100 K102 W104 R105 K106 K110 N112 Q113 Q115 K116 R117 R136 Q139 T163 K183 K187 L188 R189 A190 G191 K192 M195 R196 R198 R203 R204 Y210 V220 K221 R224 N225 T231 A236 L237 N238 P244 G245 H247 K269 K270 F273 S285 I288 N289 T291 Q294 P300 K301 G302 E303 T306 K307 R308 A309 V311 Q312 K314 R318 N319 K320 Q321 R325 G339 E340 E345 G346 K347 P348 V351 L359 H360 |
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