Structure of PDB 6zme Chain LC Binding Site BS01 |
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| >6zme Chain L5 (length=3773)
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cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcggguccggccgugucggcgg
cccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggc
cgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccggg
acggcugggaaggcccggcggggaagguggcucgggggcccccgaguguu
acagcccccccggcagcagcacucgccgaaucccggggccgagggagcga
gacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggc
caccccucccacggcgcgaccgcucggggcggacuguccccagugcgccc
cgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccg
aagagggggacggcggagcgagcgcacggggucggcggcgacgucggcua
cccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcg
agucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccg
gcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgag
ggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacga
gcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcga
agccagaggaaacucugguggagguccguagcgguccugacgugcaaauc
ggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuagua
gcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacc
cgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuu
ggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagc
ccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggcc
acuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguua
aggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugau
auagacagcaggacgguggccauggaagucggaauccgcuaaggagugug
uaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcugga
gcgucgggcccauacccggccgucgccggcagucgagaguggacgggagc
ggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgc
ugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcag
gugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggc
cgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucg
guccugagagaugggcgagcgccguuccgaagggacgggcgauggccucc
guugcccucggccgaucgaaagggagucggguucagauccccgaauccgg
aguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgau
cccggagaagccggcgggagccccggggagaguucucuuuucuuugugaa
gggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuu
ggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuug
aaaauccgggggagaggguguaaaucucgcgccgggccguacccauaucc
gcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagg
uaagggaagucggcaagccggauccguaacuucgggauaaggauuggcuc
uaagggcugggucggucgcggccggcgccuagcagccgacuuagaacugg
ugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaagg
cccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugu
caaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaug
acucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaug
aauggaugaacgagauucccacugucccuaccuacuauccagcgaaacca
cagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguu
gagcuugacucuagucuggcacggugaagagacaugagagguguagaaua
agugggaggcccccggcgcccccccgguguccccgcgaggggcccggggc
gggguccgccggcccugcgggccgccggugaaauaccacuacucugaucg
uuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucg
cuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcucc
ggggacagugccagguggggaguuugacuggggcgguacaccugucaaac
gguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccgu
ggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauaca
gaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagc
aggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaa
gcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuau
cauugugaagcagaauucaccaagcguuggauuguucacccacuaauagg
gaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuac
ugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgc
agguucagacauuugguguaugugcuuggcugaggagccaauggggcgaa
gcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcc
caggcggaacgauacggcagcgccgcggagccucgguuggccucggauag
ccggucccccgccgggguccggugcggagugcccuucguccugggaaacg
gggcgcggcuggaaaggcggccgcccccucgcccgucacgcaccgcacgu
ucguggggaaccuggcgcuaaaccauucguagacgaccugcuucuggguc
gggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagu
cagcccucgacacaaggguuugu |
.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....
>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>...
..>>>>>..<<<<<<<<<<....<<<<<<<........<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>...>>>>>>.>..>>>>>>>>>>.......<<<<<<<........>>>
>>>>.....(((((..<<<<<<)))))..]]]..................
................<<....>>...............<<<<....>>>
>..................................<<<<<<<<..<<<.<
<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<.
...<<<<<.<<<..<<<<..>>>>>>>>>>>>>..>>..>>>>...>>>>
>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<
<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>...
....>>>>.>>>>>........>>>>>>..>>>>>>>>>>>.........
...........<<<<<<.<<<<<<<............>>>>>>>.<<<<<
<.<<<<.<<<<<<<<<<<.<<<<<.<<<<.<..............>.>>>
>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.
....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...
>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<.
.<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<
<<......>>>>>>>..<<<<<...<<<..<<<..(((...(((>>>..>
>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....
>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<...
.<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>
>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>.
.>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<.........
.............<<<.<<<<<<<<<...<<<....<<<..<.<<<....
<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<
<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<
<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..
.<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<
.......<<<<<.<<....<<.........>>....>>.........<<.
.....>>...>>>>>...>>>>>>>>>>>>>..........))).>>...
>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))...))).
..<.....>..................>>>>>>>>>....>>>>>>.<.<
<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>
..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<
<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<
<<<<...<<....<<<....>>>..........<<.<<<<<...<...>.
..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<
....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<
<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<
<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>
.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.....
....>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<
......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<
<<.<<...............<<<<<....<....>.....>>>>><<.<<
<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>..
..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<
<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<
.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......
>>>>>.........<...........<<<<<.......>>>>>.....>.
....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>.
...<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{
{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<..<<...............
.....................<........................>...
..............................................>>..
.>>>>>>>>...<<<<<.....<<<<........<........>......
.............<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>
>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<.....
......>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..
...<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>
>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.))))
)))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...
<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..
<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>
>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]
]]]].....<<<<<<.<..<<<..<.<<<<<.................>>
>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...
>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>
>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<
<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<
<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..........
....>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<
<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>.
...>>>>.>>>.>>..>>>>>.. |
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| PDB | 6zme Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. |
| Resolution | 3.0 Å |
Binding residue
(original residue number in PDB) | M1 R33 N38 F39 T42 L44 R45 K46 N47 N48 R49 Q50 Y52 V54 S55 A58 H60 T62 S63 T69 G70 R71 A72 V73 A74 R75 P77 V79 R80 G83 T84 R86 Q89 N94 M95 R97 R100 M101 F102 P104 W108 R109 R110 R114 N116 T118 Q119 R121 K140 K163 T164 K165 K181 K182 Y184 R188 R190 A191 G192 K193 K195 M196 R197 R199 R204 R205 K219 R222 N223 K234 L235 P242 G243 H245 R268 K269 K274 R291 L293 R303 P305 R306 K307 K308 I309 H310 R311 R312 K316 N321 L322 R323 I324 K327 K333 T339 R342 Q343 N346 H347 R350 |
Binding residue
(residue number reindexed from 1) | M1 R33 N38 F39 T42 L44 R45 K46 N47 N48 R49 Q50 Y52 V54 S55 A58 H60 T62 S63 T69 G70 R71 A72 V73 A74 R75 P77 V79 R80 G83 T84 R86 Q89 N94 M95 R97 R100 M101 F102 P104 W108 R109 R110 R114 N116 T118 Q119 R121 K140 K163 T164 K165 K181 K182 Y184 R188 R190 A191 G192 K193 K195 M196 R197 R199 R204 R205 K219 R222 N223 K234 L235 P242 G243 H245 R268 K269 K274 R291 L293 R303 P305 R306 K307 K308 I309 H310 R311 R312 K316 N321 L322 R323 I324 K327 K333 T339 R342 Q343 N346 H347 R350 |
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| Enzyme Commision number |
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