Structure of PDB 7z3n Chain LB Binding Site BS01

Receptor Information
>7z3n Chain LB (length=387) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHRKYEAPRHGSLAFLPRKRAARHRGRVKSFPKDDPKKPVHLTAAMGYKA
GMTTIVRDLDRPGAKAHKKEVVEAVTIIDCPPMVVVGLVGYIETPRGLRS
LTTVWAEHLSDEVKRRFYKNWYKSKKKAFTKYAKKYAENNGASITRELER
IKKYCTVVRVLAHTQIRKTPLKQKKAHLMEIQINGGSVADKVEFGRSLFE
KPVTIDTIFEKDEMIDVIAVTKGHGFVGVTARWGTKKLPRKTHKGLRKVA
CIGAWHPSHVQWTVARAGQMGYHHRTSVNHKIYRIGKGDDEANASTETDL
TKKKITPMGGFVRYGEVNNDYVMIKGSVPGVKKRIMTLRKSLFTHTSRKA
LEKVELKWIDTSSEFGHGAFQTAAEKKQFMGTLKKDL
Ligand information
>7z3n Chain 1 (length=3191) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guugaccucggaucagguaggaggacccgcugaacuuaagcauaucaaua
agcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaag
cggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuugg
agaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgcc
acagagggugagagccccguauaguuggaagccaagccuguguaaagcuc
cuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaau
uucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagu
gaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaa
uuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucaucc
gguguucucaccggugcacuccgccgggcucaggccagcaucgguucugg
cggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcc
cuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugc
uggcguaauggucaccagcgacccgucuugaaacacggaccaaggaguca
agguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagug
aacguaggugagagcuucggcgcaucaucgaccgauccugauguauucgg
auggauuugaguaggagcguuaagccuuggacccgaaagauggugaacua
ugcuuggauagggugaagccagaggaaacucugguggaggcucgcagcgg
uucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagacua
aucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagca
gugucgaccuucaguuuuaugagguaaagcgaaugauuagggacucgggg
gcgauuuuuagccuucauccauucucaaacuuuaaauauguaagaagccc
uuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggcc
auuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguua
aggugccggaguggacgcucaucagacaccacaaaaggcguuaguacauc
uugacagcaggacgguggccauggaagucggaauccgcuaaggacugugu
aacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaag
cgucccacccauaccccgcccucaggguagaaacgaugcccugaggagua
ggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaa
cggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaac
uugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacaug
gguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucg
ugccccguguggcgaaagggaagccgguuaauauuccggcaccuggaugu
ggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggcccc
gggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuu
gucuggagauaggguuuaauggccggaagagcccgacacuucugucgggu
ccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucuc
acgccaggucguacucauaaccgcagcagguccccaaggugaacagccuc
ugguugauagaacaauguagauaagggaagucggcaaaauagauccguaa
cuucgggaaaaggauuggcucuaaggguugggcacguugcggcgugcggu
uaacaaccaacuuagaacugguacggacagggggaaucugacugucuaau
uaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauu
ucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggg
uaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucguc
aucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccu
aucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaauca
gcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaa
agacauaggagcuccuauuguuuuuuuacuuauucaaugaagcggggcug
gacuugcguccaacuucuggaguuaagguccuucgcgggccgacccgggu
ugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaa
ccauaacgcagguguccuaaggggggcucauggagaacagaaaucuccag
uagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauac
aaaccaugaaaguguggccuaucgauccuuuagucccucgaaauuugagg
cuagaggugccagaaaaguuaccacagggauaacuggcuuguggcggcca
agcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccua
ucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauag
ggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccua
cugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcu
gauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaag
cuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugcc
agaacgcgacgauacuacccgcacguuguagacguauaagaauaggcucc
ggccucguauccuagcaggcgauuccuccgccggccucgaaguggccguc
gguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugca
gacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguu
guuacgaucugcugaggguaagcccuccuucgccuagauuu
.........................<<<<<<.....<......>......
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.>>>>...[[[..<<.......<<.<<<....>>>.>>.......>>...
.<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((.
.....<<<.....))>>>....>>..>>.>>>>..>>>>....>>>>>>>
>.>>........<<<<<<<........>>>>>>>.....(((((..<<<<
<<)))))..]]]..................................<<..
..>>...............<<<<....>>>>...................
...............<<<<.<<<<<<.....<<.<<<<<<<<<<....<<
<<<<....>>>>>>.....>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<
<<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>
>>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>
>>>>.....>>>>>>.>>>>..<<<<........>>>><<<<<<....<<
<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.
......<<<<<..<<<..>>>...>>>>>.<<<<<<<<...<<....>>.
..>>>.>>>.>>....>>>>.>>>>>>>>..<<.<...<<<<<<.....<
<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<.
.<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>.
.....>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<
<<<<<<.....<<.<<<<<<<.....<<<....<<<....<<<...<<<<
<<........>>>>>>.>>>....>>>..>>.>.....>>>>>...<<<<
.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<
<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..
.<<<((......<<<<<<.....<<..........<<<.<<<<<<<<<<.
......<<<<<.<<<...<<.........>>...>>>.........<<..
....>>...>>>>>...>>>>>>>>>>>>>...........)).>>...>
>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....
>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>
>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......
>>>>>><<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>
>....((<<<<<<...<<<...<<<....>>>........<<<<<.....
.>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<
<.<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<
<<<.<<<<.......>>>>.><...<<<<<....<<<<<<....<<<...
..>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>
>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>...>
>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.
.>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....
<<..>>.....>>>>><<.<<<<<<<<<<<.<<<<<<<..>>>>>>>...
...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.....
....>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<
<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>
>..>>>>><<<<<<.......>>>>>>........<...........<<<
<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>
>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[
[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<
<<<<<.<<<<..>>>>..>>>>>>>>>>>...<<<<<.....<<<<..<<
<<<....>>>>>..............<<<<<.....>>>>>..>>>>..>
>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<....
.......>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.
....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>
>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))
))))))..........]]]]..}}]]]].......<<..<<.<<<<<<..
.<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<.
.<.<<<<<<<......>>>>>>..>.>.<<<.........>>>.....>>
>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.
]]]]]....<<<<<<<..<<<<.<.<<<<<.................>>>
>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>
>>>..>>>>>.<<<<...<<<<.............>>>>...>>>>.>>>
>....>>>>>>>.....<<<<<....<<<......<<.......<<<<..
>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>
>>....>>>>..............>>>...>>>>>...<<<<<<<.....
........>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......
>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z3n Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.
Resolution3.2 Å
Binding residue
(original residue number in PDB)
S2 H3 K5 E7 A8 P9 R10 H11 G12 S13 A15 P18 K20 R21 H25 K30 S31 M53 T55 A75 Y92 P96 R97 L99 R100 S101 L102 T104 R116 R117 K120 Y123 K124 K128 A129 K132 Y133 R151 Y155 R168 Q174 K175 K176 E181 T222 K223 G224 H225 G226 F227 G229 K237 K238 R241 K242 T243 H244 K245 G246 R248 K249 A251 C252 A255 W256 H257 S259 H260 V261 T264 R267 A268 H275 R276 N280 G310 R314 Y315 S328 P330 V332 R335 S364 E365 F366 H368 K377 M381 L384 K385 K386
Binding residue
(residue number reindexed from 1)
S1 H2 K4 E6 A7 P8 R9 H10 G11 S12 A14 P17 K19 R20 H24 K29 S30 M52 T54 A74 Y91 P95 R96 L98 R99 S100 L101 T103 R115 R116 K119 Y122 K123 K127 A128 K131 Y132 R150 Y154 R167 Q173 K174 K175 E180 T221 K222 G223 H224 G225 F226 G228 K236 K237 R240 K241 T242 H243 K244 G245 R247 K248 A250 C251 A254 W255 H256 S258 H259 V260 T263 R266 A267 H274 R275 N279 G309 R313 Y314 S327 P329 V331 R334 S363 E364 F365 H367 K376 M380 L383 K384 K385
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7z3n, PDBe:7z3n, PDBj:7z3n
PDBsum7z3n
PubMed37081320
UniProtG0RXW1

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