Structure of PDB 7ug7 Chain LB Binding Site BS01

Receptor Information
>7ug7 Chain LB (length=271) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITT
RHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGER
RYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKG
GQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHM
LRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQ
TKGKKTRSNKRTDKFIVRRRS
Ligand information
>7ug7 Chain 16 (length=1514) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccua
acacaugcaagucgaacgguaacagguuugcugacgaguggcggacgggu
gaguaaugucugggaaacugccugauggagggggauaacuacuggaaacg
guagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggc
cucuugccaucggaugugcccagaugggauuagcuaguaggugggguaac
ggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccac
acuggaacugagacacgguccagacuccuacgggaggcagcaguggggaa
uauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaaga
aggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguu
aauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacucc
gugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuac
ugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaaucccc
gggcucaaccugggaacugcaucugauacuggcaagcuugagucucguag
agggggguagaauuccagguguagcggugaaaugcguagagaucuggagg
aauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugc
gaaagcguggggagcaaacaggauuagauacccugguaguccacgccgua
aacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcg
uuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaa
uugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaa
cgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagauga
gaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagc
ucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauc
cuuuguugccagcgguccggccgggaacucaaaggagacugccagugaua
aacuggaggaagguggggaugacgucaagucaucauggcccuuacgacca
gggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcga
gagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaa
cucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccac
ggugaauacguucccgggccuuguacacaccgcccgucacaccaugggag
uggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccac
uuugugauucaugacuggggugaagucguaacaagguaaccguaggggaa
ccugcgguuggauc
........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<....
.<<<.<<<..<<<..<<.<<..<<<.....>>>>>..>>>>>......<<
.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>
>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>
>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<......
...>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>
.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.....
....<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.....
.<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<..
.....>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<
<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>........
..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<
<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<..
.<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>.
..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>
....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>....
......<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.
....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).
]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......
..>>..........<<<<<<<......<.<<<<<..<<<<<<<....>>>
>>>>...<<....>>..>>>>>.>...<<.<<<..<<<<<<.......<<
<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<
<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<....
.>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>
>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....
>>>...>>....>>>.....>>>>>>>......<....<<<<<<<.....
...>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>
>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<
<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...
>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....
>>>>>>>>>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ug7 The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		R175 M201
Binding residue
(residue number reindexed from 1)		R174 M200
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0032297 negative regulation of DNA-templated DNA replication initiation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990082 DnaA-L2 complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ug7, PDBe:7ug7, PDBj:7ug7
PDBsum7ug7
PubMed35500116
UniProtP60422|RL2_ECOLI Large ribosomal subunit protein uL2 (Gene Name=rplB)

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