Structure of PDB 8rxh Chain LA Binding Site BS01

Receptor Information
>8rxh Chain LA (length=258) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKTVLSCRKGNGSVYQVHGHKRLGPAKLRILDYAERHGYMRGVVKSIEHE
AGRGAALARVEFRHPYKFRRVKELMVAPEGMFTGQSVFCGQKAPLAIGNV
LPLGQITEGCIVCNVEAKPGDRGTLARASGDYCIIISHNHETGRTRLKLP
SGQKKSVPSTSRAMIGIISGGGRIEKPVLKAGNSFYRFRGKRNCWPKVRG
VARNPVEHPHGGGNHQHIGHPSTVSRHSPPGQKVGLIAARRTGRIRGGKA
VKGAWHPE
Ligand information
>8rxh Chain L1 (length=1677) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacucag
cggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaaga
gggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggc
acaaauaucauugugugguuggugcaggaguggcgaaauucaagcgaaaa
gcaaacccguugcugaauacaacccuucaugugaguauugagccaaagaa
gguguuagcccauugagccauaaaccugagcgccucaugaauaagcgagu
agcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaa
guuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaa
guuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugac
aaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugc
auuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaucu
ugggucuuggugaaaugagcggaguauuugagcugcgcacggcgcgccgc
acgcacugguuucuucuccgugaugcuccauguuggcgauggaaaugggg
ugcccccacccgucuugaaacacggaccaaggagucaaacagacgcgcaa
gggaggagauaugguugccaguacuucucucguacugaaagggagaugca
aaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacac
cgaccggcccuccguggguugcguuggagugugccuguuuggacccgaaa
gguggugaacuaugccugaacaaggugaagcccggggaaacccaggugga
ggccuguagcgaugcugacgugcaaaucgcucguaugauuuggguaucgg
agcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucc
cucaggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauu
agaggucgaccuauucucaaacuuuaaaugugcaaacaaaccgugccuua
gccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuu
cuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggauaugug
gcgucaaaacuuaugggcucauucucgauacgugaaaaggguguuggugg
auacaguuggacccaaccgaauccaccggccccgaaaauggaugacgcuu
aagcccaauuagugauugcccauuauuccuuugguaagggcggaaacaaa
uggagaaaguguagcccuuccgauguagauguggccuggagguuaggacg
aagcuuauggcgugagccuaagauggaccggccucuagugcagaucuugg
uuggcguagcaaagaucuaacggagauauacucaacaugcaacguuggau
acuggagcggggaaggauuucgugccaacggcacucguacacgaguuguu
cggaaacugagcacaacguuauaucguuuuguuaggaaagugaaggugug
ucggcggagcuguucgacugugaaaaggggcaacagagaaccugggauua
uauuccaaaaagaaauugcauguggga
.......................<<<<<......<......>.......>
>>>.>.........<<....>>..<<<<<<......<<.....>>....>
>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>
>............<<<<...<<<<<<<<.<<<<<......<<<......<
<<<.......>>>>.....<<........>>......>>>.<<.......
((.....>>)).....>>>>>...>>>..>>>>>.>>>>...........
.<<<<<<<........>>>>>>>......<<<<<........>>>>>..>
>>....................................<<....>>....
............<<<<....>>>>..........................
........<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<
<<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>........
.>>>>..>>>>........<<<<<.....<<<<<..<<.<<<<..>>>>.
..>>...>>>.>>..>>>>>.....<<<<...>>>>>>....>>>>>>>>
>>>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..
<<<..<<<.<............>>>>..>>>...<<....>>..<<<<<.
....>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>
><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<..<
<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>...
..>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...
<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<
....>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<<..
..<<<....>>>....>>>..>.>>...>>>>>>>.....<<<.<<<<<.
<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.
<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<
<<(((......<..<<<<........<...........<<<.<<<<<<<<
<<..................>>>>>>>>>>>>>..........))).>..
..>>>>.>.........>>>...>>>>>>><<<<.<<<<<..........
.>>>>.........>>>>>>>>>....>>>>>....<<<<<<<<......
...<<<..<<<....>>>.>>>.......>>>>>>>>........>>>>>
>..............<<<<<<<....................>>>>>>>.
...................<<<<<....<<.....>>..>>>>>....<<
..........<<.<<<<<......>>>>............<..<.<..<<
.....<...>....>>..>.>..>...>.>>..........<<<<.....
....>>....>>.>>............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		G2 K3 T4 R9 S14 V15 Y16 H19 H21 P26 K181 A182 G183 F186 Y187 N194 W196 V199 A203 R204 N205 V207 E208
Binding residue
(residue number reindexed from 1)		G1 K2 T3 R8 S13 V14 Y15 H18 H20 P25 K180 A181 G182 F185 Y186 N193 W195 V198 A202 R203 N204 V206 E207
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
PDBsum8rxh
PubMed38722744
UniProtQ4FWX5

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