Structure of PDB 8fks Chain L8 Binding Site BS01

Receptor Information

>8fks Chain L8 (length=135) Species: 9606 (Homo sapiens)

VFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMP
FKCMQLTDFILKFPHSAHQKYVRQAWQKADINTKWAATRWAKKIEARERK
AKMTDFDRFKVMKAKKMRNRIIKNEVKKLQKAALL

Ligand information

>8fks Chain L3 (length=1824)

gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcgg
aggagaagaaacuaaccaggauucccucaguaacggcgagugaacaggga
agagcccagcgccgaauccccgccccgggggcgcgggacauguggcguac
ggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugau
cgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgc
cgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagc
gggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaag
uaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggc
gugaaaccguuaagaggacgggugggguccgcgcaguccgcccggaggau
ucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgc
cgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucg
ggcccgaguguuacagcccccccggcagcagcacucgccgaaucccgggg
ccgagggagcgccgcgcucuccggccgggccaggccacgcgagcgcacgg
ggucggcggcgacgucggcuacccacccgacccgucuacacggaccaagg
agucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgc
aaggugggaucccgaggcgccgagggcgcaccaccggcccgucucgcccg
gggagguggagcacgagcgcacguguuaggacccgaaagauggugaacca
ucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuc
cgcaguuuuauccgggguaagaagcccggcucgagccgggcguggaaugc
gagugccuagugggccacuuuugguaagcagaacuggcgcugcgggauga
accgaacgccggguuaaggcgcccgaugccgacgcucacccagaaaaggu
guugguugauauagacagcaggacgguggccauggaagucggaauccgcu
aaggaguguguaacaacucaccugccgaaucaacuagcccugaaaaugga
uggcgcuggagcgucgggcccauacccggccgucgccggcagucacgcua
cgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcg
cgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaau
guuggaacaauguaggaccuacuauccagcgaaaccagccaagcuuggcu
cagcggggcuggcuuguggcggccaagcgcgacgucgcuuuuugauugug
aagcagaauucaccaacccuacugaugguuguugccaugguaauccugcu
caguacgagaggaaccgcagguucagacauuugguguaugugcuuggcug
aggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccu
cuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucggu
uggccucggauagccgguccccgggguccggugcggagugcccuucgucc
ugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgc
accgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugc
ugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauu
gaaagagcccucgacacgguuugu

........................<<<<<<...............>>>>>
.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>
>..<<<...<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>...
<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<.....
.>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>
>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....
<<<<<<.>>>>>>..>>>................................
..<<....>>...............<<<<....>>>>.............
..................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.
....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<<
<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<
<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>
>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>.>>>>>>....
..>>.>>>>>...>>>>>...>>>>>>>>..<<<<....>>>><<<<<<.
...<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>..
..<<<<<...<<<..<<<>>>..>>>....>>>>>.<<<<<<<<<.<<..
>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<..>>>>
>>......>.>>..<<<<<<......<<<....>>>..<<.<<<<<<<..
.<<<.<<<<<<<<.>>>>>>...<<<<<<<<..>>>>>>>>....>>>>>
>>>>>>>..>>..<<<<.<<<<<...[[>>>>>.>>>>....<<<.....
.>>>...<<<<<<<...<<<(((.......<<<<<....<<<....<<<.
<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>..
.......<<......>>...>>>>>...>>>>>>>>>>>>>.....>>>.
.)))......>>>>>..>>>...>>>>>>><<<<<<.<<<..........
.>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<.
...>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<....
..<<<<.....<<<<<.>>>>>..>>>>.>....>>.<<<<<<>>>>>><
<<<.<<<<]].......<<<<<<...<..>...>>>>>>........<<<
<<......>>>>>...>>>>.>>>>..<<<<<<.<..<<<..<.<<<<<.
................>>>>>.><<<<....<<<<...<.<..<<<<<<.
...>>>>>>....>...>>>>>...>>>><<<<<...<<<<<........
...>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<...
.<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..
<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>.
.............>>>>..>>>>>>>>.<<<<<.<.............>.
...<<<<<<<<<<.....<<<<....<<<<<......>>>>>...>>>>.
...>>.>>>>>.>>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fks Principles of human pre-60 S biogenesis.
• Resolution: 2.88 Å
• Binding residue (original residue number in PDB): F3 R4 R5 F17 H20 D29 N34 Q44 V45 R46 Q48 K53 Q56 P65 H69 Q70 K71 Y72 W91 K94 R98 K101 M113 K114 K117 M118 R121
• Binding residue (residue number reindexed from 1): F2 R3 R4 F16 H19 D28 N33 Q43 V44 R45 Q47 K52 Q55 P64 H68 Q69 K70 Y71 W90 K93 R97 K100 M112 K113 K116 M117 R120

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0045296 cadherin binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006364 rRNA processing
• GO:0006412 translation
• GO:0042273 ribosomal large subunit biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0014069 postsynaptic density
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0045202 synapse
• GO:0070062 extracellular exosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8fks, PDBe:8fks, PDBj:8fks
• PDBsum: 8fks
• PubMed: 37410842
• UniProt: P50914|RL14_HUMAN Large ribosomal subunit protein eL14 (Gene Name=RPL14)