Structure of PDB 8hl5 Chain L34E Binding Site BS01

Receptor Information
>8hl5 Chain L34E (length=77) Species: 330779 (Sulfolobus acidocaldarius DSM 639) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPQQRSGSFRKVFVKLPSGKSTIHYERRKDNIARCGMCKKPLNGVKNNYT
YKYSKTEKRPERVYGGYLCHKCLESLI
Ligand information
>8hl5 Chain A23S (length=2991) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagccucccgguggauggcucggcucgggcaccgaagaagggcgcggcaa
gcagcgaaaugcucgggugaggcgcaagcagccguugaccccgagguccc
cuaaugggauauccugccggguuccggcgcccgguuuauaacuggguggg
aaccccccgaacggaaacaucuuaguagggggaggaaaagaaaucaauug
agauccccugaguaggggcgaccgaaagggggacagcccaaacuaaaccu
gccgaugauaagucgguggggaugugguguuacgaccucuagccugaggu
ugaccucggcuuuccuaaccuaucuagccgaacuccccuggaacgggggg
ccauagagggugaaagccccguaggcuaaagauagguggaaaguggcuag
agguagaguaccauccccugguuugggggugggaaguuaggggacacgug
ccucuaaggcuaaauaugucccgagaccgauagcaaacuaaguaccguga
gggaaagcugaaaagaaccccggaagggggagugcaaagagccugaaacc
gggugguuauacaggguguggcucgaaagaagugaacccuuccgaaggaa
aggggcgcaagcccuuaguacgaggaagggcgaucggggucacgccuuuc
gucuugaaacacgggccggggaguucacaucaguggcgagcuuaaggaga
uuaucuccgaaggcauagggaaaccaagugcccgcagccuaguuucuagg
cgaggggcagggucugucagggccugaagccacugaugugaggcuagaaa
ccgggcgaucuaguccggggcaggcugaaggugggggaaaccccacugga
gggccgaauagggguucugacgugcaauucguucccuugaccucggacua
ggggcaaaagaccaaucuagcccggugauagcuaguuccccccgaaaugc
guccuagcgcagccucccuaaaggcagcucgcgggguagagugacagauc
gggggcuccaggcgccuggggcuuccggucuaacuccgaacccacgagcg
ccgaagaaggggggagugggucacucggcguaagguuggguggcaaaagg
ggaacaacccagaccuggguuaaggccccaaagucccggcuaagugccaa
cgaaaaggcgucuccagccuuagacagcgggaaggugggcccagcagcag
ccauccucuaaggagugcguaacagcucacccgccgaggcuggaggcccu
aaagauuggucggggcucaagccgggcgccgagacccaggagggggucuc
uacugagauccucugguaggggggcgcugugaugggguagaagguggguc
gugagauccacuggacccgucacaggugcagaucccggcgguaguaacag
cgaaggggggugagaaucccccucgccggaagggcaaggguuucccggca
acguucgucagccgggaguuagcguccuaagguagggccuaauagguacc
uaccgaaagggaaagggguuaacauuccccugccucccggguaggugcgg
uaacgcaagccagacuccugacggauugggguagggagaguaggaccacc
guccuacccaagcacucaagcccuuggagagccguaacggugagaagagg
gcgaaggugugaugggccuuccguuaggaggguucuccugaucccuaguc
cccaugaaaagggagucuggaacgaucccgggagaccguaccuagaaccg
acacuggugcccgggugagaagcccaaggcgucugagggguaacccaggc
uagggaacucggcaaauuagccccguaacuucgggagaaggggugccuau
cgugguuuaacaaagccacgauaggucgcagugaccagagggaccugacu
guuuaauaaaaacauagguccccgcuagcccgaaaggguguguacggggg
cuaaauccuggccacuggugguugguuaaauccggguucaaccgggcgaa
gccccaccgaaggccggggguacccucuuaagguagccaaaugccuugcc
ggguaaguuccggcgcgcaugaauggaucaacgcggucccuacuguccca
gccuggggccucgugaacgcccugagccggugcacaguccggcaucuccc
uacaccgagagaagaccccguggagcuucaccgcagccuggcguuguccc
ucgggcguuuaugcguagaguaggugggaggggucgaaccuguccuuucg
ggggcaggggacccgaaagugaaacaccacccauggacgcucgagggacu
aaccucucgaaagagaggaacaacgucaggugggcgguucggcuggggcg
gcacucccgcgaaaagauaacacgggagcccaaaggucggcucaggcggu
acagaacgccgccguagagcgcaagggcaaaagccggccugacgugaccc
uuccaaguacggggucacgacgcgaaagcggggccuagcgaacgcucgug
cccccacacgugggggccgggcaugacagaaaaguuaccccggggauaac
agggucgucgcgggcgagagcucacaucgaccccgcgguuugcuacaucg
augucggcucuucccacccuggaggugcagcugccuccaaggguagggcu
gcccgcccguuaaaggggagcgugagcuggguuuagaccgucgcgagaca
ggucggacucuaaggguagggagugcggaccgcuugaggggaaggaaccc
cuaguacgagaggaacaggguuccggggccuccaguuuaccgguuguccg
guagggcaaugccgggcagccgcgcccugagggguaaccgcugaaagcau
cuaagcgggaaccccuccccuaaaagaggcggucaggcgccggggccuuc
cccuagaagaggggguugaugggguggggauguaagcuccaagguuguaa
gaccgaggaguuuaguccgccacucccaaucaggcuccccc
<.<<<.<<<<<<.....<<..<<<<<<<<<<<<.....<<<<<<<.((..
((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>
>>...<<<....>>><<<<<<.>>>>>><<<<<<<<...>>>>>>>>>>.
..<<<<<<....<<<....>>>.....>>>>>.>.........<<....>
>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<
<<<<<<.....>>>>>>>>>.....>>>......<<<<<<<<<<<<<<<<
..>>>>>><<<<<<<...<<<<<<<.<<<.....<<<<......>>>>.(
(......<<<.....))>>>...>>>...>>>>>>>.>>>>>>>>>>>>>
>>>>......<<<<<<<<......>>>>>>>>.......<<<<.((((((
>>>>...>>>......>>.>>>>>>.>>................<<....
>>....>>.........<<<<.....>>>>.................>>>
>>>.>>>>......<<<<<<<<<<....<<......<<<<<<<...<...
.<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>..<<
<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<
...>>>>>...>>>...<<....>>...<<<<<...<<<<.......>>>
>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<<<..<
<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>...
..>>>....<<<<<....<<........>>..>>>>>...>>>>>>>>>.
..<<.......>>......>>>>>>...>..>>>>..<<<<<<....<<<
<<....>>>>><<<<<<<<...<<<.<<<<<.<<<...<<<....<<<<<
<<<<<<<<<<<<<>>>>>>>>>>>>>>>>>>..>>.>...>>>.>>>>>>
>>......>>>>>>.>>..<<<<<<.<<<.....>>>.>>>>>>....<<
<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...
.....<<<.<<<<<<<<<<.......<<<<..<<....<<.........>
>....>>.........<<......>>....>>>>...>>>>>>>>>>>>>
...........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<<<<
....>>>>>>>>>>....>>>>>><<<<<<<<<.<<<.....<<<<<<<<
....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><......<<..
....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<..
..<.....>..>>>>>>....<.{<<<...<<<<<<.<<.....>>..>>
>>>>....>>>..<<<<<........>>>>>.><<<<<<<<.....<<<.
...>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<<.[[[
>>>>>>>....<<<<.<..<<<<<<.....<<<<...>>>>.....>>>>
>>...>>>>>.....<<<<<<<....>>>>>>>>>>>>>...>>>>>>>>
>.........>>>>>>>>>>......>>>>>>>>.}....>>.....<<.
.....>>.>>>><<<<.....>>>>..>>>>...<<<<.....<<<<<<<
<.<<...............<<<<<.....<..>......>>>>><<<<<<
<<<<<<<......>>>>>>>>>>>>>............<<<<<<<<<..<
<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>
>>..<<<<.<<<..<<<<<<<..<<<<...<<<<<......>>>>>...>
>>>>>>>>..>>>>><<<<<..>>>>>....................<<<
<<<.....>>>>>>..........>>>>...>>.>>>>>>>.....>>.>
>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<
<<<.<<..<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<
<<<<<<<<<.<<<.........<<<<<..<<<...........<.<....
.>.>.......>>>............>>>>>>>>.>>>>>>>>>>>>>>.
..<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>
>>..<<<<<.............>>>>>.(<<...<<<<<<<...<<<<<<
.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<<<<<
<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<
<<<<..))))))>>>>>>>>>>..........>>>>..>>>>>>......
.<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>....
.....<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.
....>>>>......>>>>...>...>>>.......<<<<<<<....>>>.
>>>>....>>...>>>>>>>>>>....<<<<<<<..<<<<<..<<<<<<<
.................>>>>>>><<<<<.....<<...<<<<<<<<<<]
]].>>>>>..>>>>>...>>...>>>>>.<<<<<...<<<<<........
...>>>>>...>>>>>>>>>>......>>>>>>>.<<..>><<<<<<<<<
<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<<<....
>>>>..>>>>>...>>>>.>>>>>.>>>...>>>>>>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8hl5 Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome
Resolution5.72 Å
Binding residue
(original residue number in PDB)
S3 P4 Q5 Q6 R12 K13 F15 V16 K17 L18 P19 S20 G21 K22 R29 R30 K31 N33 I34 A35 R36 C37 G38 M39 C40 N45 G46 K48 Y55 S56 K57 T58 E59 R61 P62 E63 R64 Y66 Y69
Binding residue
(residue number reindexed from 1)
S1 P2 Q3 Q4 R10 K11 F13 V14 K15 L16 P17 S18 G19 K20 R27 R28 K29 N31 I32 A33 R34 C35 G36 M37 C38 N43 G44 K46 Y53 S54 K55 T56 E57 R59 P60 E61 R62 Y64 Y67
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8hl5, PDBe:8hl5, PDBj:8hl5
PDBsum8hl5
PubMed37604686
UniProtO05981|RL34_SULAC Large ribosomal subunit protein eL34 (Gene Name=rpl34e)

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