Structure of PDB 7azs Chain L2A Binding Site BS01

Receptor Information
>7azs Chain L2A (length=272) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVKKFKPYTPSRRFMTVADFSEITKTEPEKSLVKPLKKTGGRNNQGRITV
RFRGGGHKRLYRIIDFKRWDKVGIPAKVAAIEYDPNRSARIALLHYVDGE
KRYIIAPDGLQVGQQVVAGPDAPIQVGNALPLRFIPVGTVVHAVELEPKK
GAKLARAAGTSAQIQGREGDYVILRLPSGELRKVHGECYATVGAVGNADH
KNIVLGKAGRSRWLGRRPHVRGAAMNPVDHPHGGGEGRAPRGRPPASPWG
WQTKGLKTRKRRKPSSRFIIAR
Ligand information
>7azs Chain 16SA (length=1511) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagaca
ugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgg
gugaguaacgcgugggugaccuacccggaagagggggacaacccggggaa
acucgggcuaaucccccauguggacccgccccuugggguguguccaaagg
gcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggg
uaauggcccaccaaggcgacgacggguagccggucugagaggauggccgg
ccacaggggcacugagacacgggccccacuccuacgggaggcagcaguua
ggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggagg
aagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgac
gaggggacugacgguaccgggguaauagcgccggccaacuccgugccagc
agccgcgguaauacggagggcgcgagcguuacccggauucacugggcgua
aagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaa
ccgugggggagcgugggauacgcucaggcuagacggugggagaggguggu
ggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccga
uggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgu
ggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugc
gcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcg
ccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggg
gcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaa
ccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugc
cccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgu
gccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguua
guugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgg
gaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcg
acacacgugcuacaaugcccacuacaaagcgaugccacccggcaacgggg
agcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccga
ccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggug
aauacguucccgggccuuguacacaccgcccgucacgccaugggagcggg
cucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcc
cgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcu
ggaucaccucc
...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.
<<<..<<<..<<.<<<<<<<<<.<...>.>>>>>>>>>.>>>>>......
<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<....
..>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<
<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.
......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>
>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>
........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.
.....<<<<....>>>>.....>>>>....<<<<<........<<<<...
..>>>>..........>>>>>......<<<<<(((...<<<<<.....<<
.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.
....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....
>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<
....<<<<<<<.<..<<<......>>>.....>.>>>>>>>.........
..<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<
<<...<<...<<<<.........>>>>...>>>>>>>>..........<<
<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>
>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<
<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>.....
.....<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....
<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<
<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<
<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>
>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...
>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>.
.>>....>>>.....>>>>>>>...........<<<<<<<........>>
>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>.
.....>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<
<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>
>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>
...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7azs Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Q166 K202
Binding residue
(residue number reindexed from 1)		Q165 K201
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0016740 transferase activity
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7azs, PDBe:7azs, PDBj:7azs
PDBsum7azs
PubMed36827973
UniProtP60405|RL2_THET8 Large ribosomal subunit protein uL2 (Gene Name=rplB)

[Back to BioLiP]