Structure of PDB 7azs Chain L22B Binding Site BS01

Receptor Information
>7azs Chain L22B (length=113) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEAKAIARYVRISPRKVRLVVDLIRGKSLEEARNILRYTNKRGAYFVAKV
LESAAANAVNNHDMLEDRLYVKAAYVDEGPALKRVLPRARGRADIIKKRT
SHITVILGEKHGK
Ligand information
>7azs Chain 23SB (length=2875) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucaagaugguaagggcccacgguggaugccucggcacccgagccgauga
aggacguggcuaccugcgauaagccagggggagccgguagcgggcgugga
ucccuggauguccgaaugggggaacccggccggcgggaacgccggucacc
gcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagag
gagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggacc
agccuaaaccguccggcuuguccgggcggggucguggggcccucggacac
cgaauccccagccuagccgaagcuguugggaagcagcgccagagagggug
aaagccccguaggcgaaagguggggggauaggugaggguacccgaguacc
ccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggc
uaaguacuccgggugaccgauagcgcaccaguaccgugagggaaagguga
aaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuaca
agcagucacggccccgcaagggguuguggcgugccuauugaagcaugagc
cggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguag
ggaaaccgaguccgaacagggcgcaaacggcccgaaaaguccgcggccgu
ggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugag
acccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcu
ggggcuaggagugaaaagcuaaccgagcccggagauagcugguucucccc
gaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcac
ugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaa
gggucccagguggagccugggagugagggcgcgagcgauaacguccgcgu
ccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggc
uaagugguaaaggauguggcgccgcgaagacagccaggauguugaucauu
uaaagagugcucacuggucgaguggcgccgcgccgaaaaugaucggggcu
uaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguagg
ggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggaggu
aagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucc
cucucgccguaagcccaaggguuccuacgcaauggucgucagcguagggu
uaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccggu
uaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuag
ggggaccggagccauggacgagcccggccagaagcgcagggugggaggua
ggcaaauccgccucccaacaagcucugcgugguggggaagcccguacggg
ugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccu
gcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacu
caggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccgua
acuucgggagaaggggugcucccuggggugaugagccccggggagccgca
gugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacu
cguaagaggagguauagggagcgacgcuugcccggugccggaaggucaag
gggaggggugcaagccccgaaccgaagccccggugaacggcggccguaac
uauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccug
cacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaa
auugaacuggccgugaagaugcggccuacccguggcaggacgaaaagacc
ccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcgua
ggauaggugggagccugugaacccccgccuccgggugggggggaggcgcc
ggugaaauaccacccuggcgcggcugggggccuaacccucggaugggggg
acagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaa
cggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagc
gcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggc
gaaagccgggccuagugaaccgguggucccguguggaagggccaucgauc
aacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguc
cacagcggcggggagguuuggcaccucgaugucggcucgucgcauccugg
ggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacg
cgagcuggguucagaacgucgugagacaguucggucucuauccgccacgg
gcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaaggg
acgcaccucugguuucccagcugucccuccaggggcauaagcuggguagc
caugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccc
caagaugaggccucccacggcgucaagccgguaaggacccgggaagacca
cccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccg
gucccaaucguccgaggucuugacc
<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<.....
.<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<
<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>..
.........<<....>>...<<<<<.....<<.....>>....>>>>>..
.<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<
<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<..
...))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<
<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>
......>>.>>>>>>.>>...............<<....>>....>>...
......<<<<....>>>>..................>>>>>>>>>>>...
....<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<
<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<
<....>>..<<<<.....>>>>.....<<...>>....>>>>>>>>>>>>
>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<.....
.>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>
>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<
....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...
<<<<<<<<...<<<.<........>.>.>>...>>>>>>>>..>>.>...
>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>
>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<
...........<<..<<<<<<<<<......<.<<<<<.<<.......>>.
.............>>>>>.>..>>>>>>>>>.>>..........)))...
...>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>
>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>
..>>>>>........>>>>>><......<<.....<<<<<<.......>>
>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>..
..((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<.
.......>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<
<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.
<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>
>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>
>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>
..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...
............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>....
........<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<
<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<
<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<...
....>>>>>>........<...........<<<<<<.....>>>>>>...
..>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...
..>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<
<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<......
.....<<.....<<.......<<<<.<<<....>>>.>>>>....>>...
............>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>.
...>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<..........
.>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<
...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<
....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>...
..........>>>>..>>>>>>.......<<<<.<.<<<<<<...<<...
....>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<
<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>
...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>
>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>
.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>
>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>
>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......
>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>
>>.>>>...>>>>....>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7azs Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K4 A5 I6 A7 R8 Y9 R11 S13 R15 K16 R18 R25 N40 K41 R42 Y45 K49 E52 S53 A56 N57 N60 N61 H62 D77 E78 P80 K83 R84 P87 R88 A89 R90 G91 R92 A93 D94 I96 K97 K98 R99 H102
Binding residue
(residue number reindexed from 1)		K4 A5 I6 A7 R8 Y9 R11 S13 R15 K16 R18 R25 N40 K41 R42 Y45 K49 E52 S53 A56 N57 N60 N61 H62 D77 E78 P80 K83 R84 P87 R88 A89 R90 G91 R92 A93 D94 I96 K97 K98 R99 H102
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7azs, PDBe:7azs, PDBj:7azs
PDBsum7azs
PubMed36827973
UniProtQ5SHP3|RL22_THET8 Large ribosomal subunit protein uL22 (Gene Name=rplV)

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