Structure of PDB 7azo Chain L21B Binding Site BS01

Receptor Information
>7azo Chain L21B (length=101) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFAIVKTGGKQYRVEPGLKLRVEKLDAEPGATVELPVLLLGGEKTVVGTP
VVEGASVVAEVLGHGRGKKILVSKFKAKVQYRRKKGHRQPYTELLIKEIR
G
Ligand information
>7azo Chain 23SB (length=2873) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucaagaugguaagggcccacgguggaugccucggcacccgagccgauga
aggacguggcuaccugcgauaagccagggggagccgguagcgggcgugga
ucccuggauguccgaaugggggaacccggccggcgggaacgccggucacc
gcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagagga
gaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccag
ccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccg
aauccccagccuagccgaagcuguugggaagcagcgccagagagggugaa
agccccguaggcgaaagguggggggauaggugaggguacccgaguacccc
gugguucguggagccaugggggaaucugggcggaccaccgccuaaggcua
aguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaa
agaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaag
cagucacggccccgcaagggguuguggcgugccuauugaagcaugagccg
gcgacucacggucgugggcgagcuuaagccguugaggcggaggcguaggg
aaaccgaguccgaacagggcgcaaacggcccgaaaaguccgcggccgugg
acccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagac
ccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcugg
ggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccga
aaugacuuuagggucagccucaggcgcugacuggggccuguagagcacug
auagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagg
gucccagguggagccugggagugagggcgcgagcgauaacguccgcgucc
gagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcua
agugguaaaggauguggcgccgcgaagacagccaggauguugaucauuua
aagagugcucacuggucgaguggcgccgcgccgaaaaugaucggggcuua
agcccagcgccgaagcugcgggucugggggaugaccccaggcgguagggg
agcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaa
gggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccu
cucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguua
ggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguua
auauuccggcccuucccgcaggugcgauggggggacgcucuaggcuaggg
ggaccggagccauggacgagcccggccagaagcgcagggugggagguagg
caaauccgccucccaacaagcucugcgugguggggaagcccguacgggug
acaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugc
gggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacuca
ggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaac
uucgggagaaggggugcucccuggggugaugagccccggggagccgcagu
gaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucg
uaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggg
gaggggugcaagccccgaaccgaagccccggugaacggcggccguaacua
uaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugca
cgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaau
ugaacuggccgugaagaugcggccuacccguggcaggacgaaaagacccc
guggagcuuuacugcagccugguguuggcucuuggucgcgccugcguagg
auaggugggagccugugaacccccgccuccgggugggggggaggcgccgg
ugaaauaccacccuggcgcggcugggggccuaacccucggauggggggac
agcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacg
gaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgc
aaggguagaagggggccugacugcgaggccugcaagccgagcaggggcga
aagccgggccuagugaaccgguggucccguguggaagggccaucgaucaa
cggauaaaaguuaccccggggauaacaggcugaucucccccgagcgucca
cagcggcggggagguuuggcaccucgaugucggcucgucgcauccugggg
cugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcg
agcuggguucagaacgucgugagacaguucggucucuauccgccacgggc
gcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggac
gcaccucugguuucccagcugucccuccaggggcauaagcuggguagcca
ugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgcccca
agaugaggccucccacggcgucaagccgguaaggacccgggaagaccacc
cgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggu
cccaaucguccgaggucuugacc
<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<.....
.<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<
<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>....
.......<<....>>...<<<<<.....<<.....>>....>>>>>...<
<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<.
..<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<....
.))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<
<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>..
....>>.>>>>>>.>>...............<<....>>....>>.....
....<<<<....>>>>..................>>>>>>>>>>>.....
..<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<
<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<.
...>>..<<<<.....>>>>.....<<...>>....>>>>>>>>>>>>>.
.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>
>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>
>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<..
..<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<
<<<<<<...<<<.<........>.>.>>...>>>>>>>>..>>.>...>>
>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>
.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<..
.........<<..<<<<<<<<<......<.<<<<<.<<.......>>...
...........>>>>>.>..>>>>>>>>>.>>..........))).....
.>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>
>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..
>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>
>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....
((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<...
.....>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<
<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<
.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.
....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>
>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..
>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....
..........>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>......
......<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<.
...>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<.
..<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<<.....>>>>>>.....
>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....
......<<<<<........>>>>>..<<<<<<<<.<<<.........<<<
<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<........
...<<<....<<<......<<<<.<<<....>>>.>>>>...>>>.....
.........>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>...
.>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>
>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<..
.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<..
..>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.....
........>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.....
..>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<
<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>..
.>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>.
...<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<
<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>
.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.
......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>
>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>
.>>>...>>>>....>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7azo Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		G8 G9 K10 E23 K24 K68 K69 K74 F75 K76 K78 V79 Y81 R82 R83 K84 K85 H87 R88 Q89
Binding residue
(residue number reindexed from 1)		G8 G9 K10 E23 K24 K68 K69 K74 F75 K76 K78 V79 Y81 R82 R83 K84 K85 H87 R88 Q89
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7azo, PDBe:7azo, PDBj:7azo
PDBsum7azo
PubMed36827973
UniProtP60492|RL21_THET8 Large ribosomal subunit protein bL21 (Gene Name=rplU)

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