Structure of PDB 6hcq Chain L2 Binding Site BS01

Receptor Information
>6hcq Chain L2 (length=96) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQ
SLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRR
Ligand information
>6hcq Chain A2 (length=1740) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugac
ucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucga
acgucugcccuaucaacuuucgaugguagucgccgugccuaccaugguga
ccacgggugacggggaaucaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacuccc
gacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggc
ccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauugg
agggcaagucuggugccagcagccgcgguaauuccagcuccaauagcgua
uauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggg
cggccguccguccccugccucucggcgccccggggcccgaagcguuuacu
uugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuagg
aauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugagg
ccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggu
gaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaag
aauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucaga
uaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcg
uuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuugggu
uccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaag
ggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaa
ccucacccggcccggacacggacaggauugacagauugauagcucuuucu
cgauuccgugggugguggugcauggccguucuuaguugguggagcgauuu
gucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuac
gcgaccccggucggcguaacuucuuagagggacaaguggcguucagccac
ccgagauugagcaauaacaggucugugaugcccuuagauguccggggcug
cacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcag
gcgcggguaacccguugaaccccauucgugauggggaucggggauugcaa
uuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugc
guugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgau
uggaugguuuagugaggcccucggaucggccccgccggggugcccuggcg
gagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucg
uaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<...((((>>>>><<<.<<<<<<.....<<.........<<<.
.<<........<.....<<..........>>....>.........<<...
.....<<<.<....<<....<<.<..........<<.....<<..<....
...>..>>......>>.........<<<<...<<<<<......>>>>>..
.>>>><<...<<<<......((((.....<..<...>..>....<.....
.>..>>>>.......>>...<<<<.<<<<.>>>>>>>>..>..>>...>>
..>.>>>.<<<....<<<.....<<<<<<.........>>>>>>.>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<.<......
...>>>.>>...<<....>>.....>>.>>>.........<<<....<<<
.....>>>..>>>......>>.......<<<<<<<<..<<<....>>>..
.>>>>>.>>>......<<..<...........>..>>.........<<<<
<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>
>.>>>.........<.<.......<.<<...<<<.<<....<<<.<<<<<
.<..>.>>>>>.>>>....<......<.<.....>>....>....<<<<<
<.<........<...<.......>..<<<.>>.>...>.......>.>>>
..>>>..........<<.<<<<<<<.........))))..>>>>>>>.>>
......>>....<<<<<<......<<<<...<..<<<<<<<<...<<<..
....>>>......>>>>>>>.>.>........<<....>>...>>>>...
..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<....
.>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<
<<<......>>>>>>>>>>.>..>>>...<<....>>...>>.....>>>
.>.>.<<<......<.<......>.>....>>>..))))...<<<<.<<<
<<<...<<..<<<<...<<<.<<<<<<......<<........>>.....
.....<<<<<......<<<<<........<...<<........>>...>.
.....>>>>>...<..<<...<<.<<<.<.....<<<.<<<<......>>
....<<......>>....>>.>>>....<<<...<...<<<<..<<<<<<
<..<<<..>>>...>>>>>>>..>>>>..>.....<<<<<.....>>>>>
........>>>.....>..>>>.....>>.>>.>.......>>>>>...>
>.>>>>.>>>.....<<.<<<................<<<.<<<<....>
>>>.>>>..............>>>.>>.............<<<<......
....>>>>.............>>>>.....<<<<<<<<.......>>>>>
>>>......>>....>>>>>>>>>.>........<<.<..<<<<......
.<<<<<<<<.<<<..<<...<<...<<<<<.<<<<<<<<<..>>>>>>>>
>...>>>>>...>>...>>..>>>.>>>>>>>>......>>>>...>.>>
..........<<<<<<<<....>>>>>>>>..........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6hcq ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Resolution6.5 Å
Binding residue
(original residue number in PDB)		M1 L2 M3 K5 R8 K25 V27 Q50 S54 F62 F67
Binding residue
(residue number reindexed from 1)		M1 L2 M3 K5 R8 K25 V27 Q50 S54 F62 F67
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Cellular Component
GO:0005634 nucleus
GO:0022627 cytosolic small ribosomal subunit

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6hcq, PDBe:6hcq, PDBj:6hcq
PDBsum6hcq
PubMed30293783
UniProtG1TPV3

[Back to BioLiP]