Structure of PDB 8uu4 Chain L Binding Site BS01

Receptor Information
>8uu4 Chain L (length=143) Species: 1642 (Listeria innocua) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTTYMAKPGEVERKWYVIDATGVSLGRLSSEVASILRGKNKPQFTPHIDT
GDFVIIINAGKIGLTGKKATDKIYYRHSQYPGGLKSRTAGEMRTNNPEKL
LELSIKGMLPKNSLGRQLFKKLHVYGGSEHEHAAQKPEVYELR
Ligand information
>8uu4 Chain A (length=2903) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaaga
aggacgggacuaacaccgauaugcuuuggggagcuguacguaagcguuga
uccagagauuuccgaaugggggaacccacuaucuuuagucggauaguauc
cuuacgugaauacauagcgugaggaaggcagacccagggaacugaaacau
cuaaguaccuggaggaagagaaagaaaaaucgauuuccugaguagcggcg
agcgaaacggaaagagcccaaaccaagaagcuugcuucuugggguuguag
gacacucuauacggaguuacaaaagaaaguuauaaaugaagcggucugga
aaggcccgccaaagacgguaacagcccgguaguugaaauggcuuucccuc
cagaguggauccugaguacgacggaacacgugaaauuccgucggaauccg
ggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaacc
aguaccgugagggaaaggugaaaagcaccccggaaggggagugaaacagu
uccugaaaccgugugccuacaaguaguuagagcccguuaaugggugauag
cgugccuuuuguagaaugaaccggcgaguuacgauuuguugcaagguuaa
gcggaaaaagcggagccguagcgaaagcgagucugaauagggcgcauaag
uaacaggucguagacccgaaaccaggugaucuacccauguccaggaugaa
gguaagguaauacuuacuggagguccgaacccacgcacguugaaaagugc
ggggaugagguguggguagcggagaaauuccaaucgaacuuggagauagc
ugguucucuccgaaauagcuuuagggcuagccucgagguaaagagucaug
gagguagagcacuguuuggacuaggggcccgguuaccgaauucagauaaa
cuccgaaugccauguacuuauacucgggagucagacugcgagugauaaga
uccguagucgaaagggaaacagcccagaccaccaguuaagguccccaaau
auauguuaaguggaaaaggaugugggguugcuuagacaaccaggauguug
gcuuagaagcagccaccauugaaagagugcguaauagcucacuggucgag
ugaccccgcgccgaaaauguaccggggcuaaacauauuaccgaaacugug
gaugaaccgguucgugguaggagagcguucuaagggcggugaagucagac
cggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcg
aaagaagggugagaaucccuuccaccgaauaucuaagguuuccugaggaa
ggcucguccgcucaggguuagucgggaccuaagccgaggccgauaggcgu
aggcgauggacaacagguagagauuccuguaccagugcuaauuguuuaac
cgauggggugacacagaaggauagggaaucgcacgaauggaaaugugcgu
ccaagcagugagugugagaaguaggcaaauccgcuucuugcgaagcauga
gcugugauggggaagcggaaguuccugauuucacgcugucaagaaaagcc
ucuaggaagaguaguacugcccguaccgcaaaccgacacagguagaugag
gagagaauccuaaggugagcgagagaacucucguuaaggaacucggcaaa
augaccccguaacuucgggagaaggggugcucuauuagggugcaagcccg
agagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggu
cucugcaaaaccguaaggugacguauaggggcugacgccugcccggugcu
ggaagguuaagaggagugcuuagcuucggcgaagguacgaauugaagccc
caguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuu
gucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacuguc
ucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacc
cgcgacaggacggaaagaccccguggagcuuuacugcaaccugauaugga
auguuuguaccgcuuguacaggauagguaggagccgaagagacgugugcg
cuagcauacgaggaggcaauggugggauacuacccuggcuguaugaccau
ucuaacccgccacgcuaagcgcguggggagacagugucaggugggcaguu
ugacuggggcggucgccuccuaaagaguaacggaggcgcccaaagguucc
cucagaauggauggaaaucauucgcagaguguaaaggcacaagggagcuu
gacugcgagacugacaagucgagcagggacgaaagucgggcuuagugauc
cggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccg
gggauaacaggcuuaucucccccaagaguccacaucgacggggagguuug
gcaccucgaugucggcucgucgcauccuggggcuguagucggucccaagg
guugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacguc
gugagacaguucggucccuauccgucgcgggcgcaggaaauuugagagga
gcuguccuuaguacgagaggaccgggauggacacaccgcugguguaccag
uuguuccgccaggagcaucgcuggguagcuauguguggcagggauaaacg
cugaaagcaucuaagcgugaagccccccucaagaugagauuucccauuuc
uucggaaaguaagaucccugaaagaugaucagguagauagguuuggagug
gaaguguagcgauacauggagcggacaaauacuaaucgaucgaggacuua
acc
<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<.....
.<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<
<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>
>......>>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<
<<<<<<<<....<<<<........<<<<<<<<<.<<<.....<<<<....
..>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>
>>>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<
<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...........
....<<....>>....]].........<<<<....>>>>...........
..}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>
>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...
<<.......>>...>>>...<<....>>..<<<<.....>>>>......>
>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....
<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>
>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>
.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.....<<<<<<<<
<.....<<<...<<<<<<<<...<<.<<<.>>>..>>...>>>>>>>>..
>>.>.....>>>>>.>>>>...>>>>>>.>>..<<<<<<<.<<......>
>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....
<<<<<<...........<<..<<<<<<<<<<.......<<<<<.<<...<
<<<.......>>>>...>>.........<<......>>...>>>>>...>
>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>
><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<
<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.
...<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...
<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>..
.>>>...>>...<<<<<........>>>>>))<<<<<<<<.<<......<
<...<<<<<...<<<<..<<<..<<<<<.<<<<<...(((....>>>>>.
<<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>..
>>>>>...>>...........>>>>>...>>>...>>>>........>>>
>>..>>..>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<
<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<..
...<<<<<.....<..>......>>>>><<<<<....<<<<....>>>>.
..>>>>>............<<<<<<<<<..<<<.........>>>..<<<
<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<
<<..<<<<..<<...<<<<<<.<<<..>>>..>>>>>>...>>..>>>>>
>>>>..>>>>><<<<<<.......>>>>>>........<...........
<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>..>..>
>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<
<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<
<<<..<<<<<.<<<...........<<<<<..<<<.......<<<<<<<.
...>>>>>>>....>>>............>>>>>..>>>.>>>>>..>>>
>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>.
.<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<
<...<<<<<.<......>>>>>>.....<<.[.(((>>....>>>>>>>.
..<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......
<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>
>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>
>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>
>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<
....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<.
.<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<
<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<
<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<
<..>>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<.
...<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>
>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8uu4 Mechanistic insights into the alternative ribosome recycling by HflXr.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R2 T4 M6 K8 G27 R28 S31 K40 H48 T66 K68 K69 K73 Y76 H78 S79 G83 L85 K86 E103 S105 G108 M109 N113 S114 R117 K121 H133 A135 Q136 R144
Binding residue
(residue number reindexed from 1)		R1 T3 M5 K7 G26 R27 S30 K39 H47 T65 K67 K68 K72 Y75 H77 S78 G82 L84 K85 E102 S104 G107 M108 N112 S113 R116 K120 H132 A134 Q135 R143
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0017148 negative regulation of translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8uu4, PDBe:8uu4, PDBj:8uu4
PDBsum8uu4
PubMed38407413
UniProtA0A0U5AGN0

[Back to BioLiP]