Structure of PDB 8uhd Chain L Binding Site BS01

Receptor Information
>8uhd Chain L (length=44) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8uhd Chain L Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8uhd Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C19 C36 C39
Binding residue
(residue number reindexed from 1)		C5 C22 C25
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex
GO:0005666 RNA polymerase III complex
GO:0005736 RNA polymerase I complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uhd, PDBe:8uhd, PDBj:8uhd
PDBsum8uhd
PubMed38401543
UniProtA0A4X1TRS6

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