Structure of PDB 8r08 Chain L Binding Site BS01

Receptor Information
>8r08 Chain L (length=301) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFAEIMMKIEEYISKQEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRF
PELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTAS
TTQGQQLSEEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSII
IGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQSVLPHTGYIYHSDIVQS
LPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQ
EKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQ
E
Ligand information
>8r08 Chain 4 (length=124) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcg
auuugcuaauugaaaacuucccaauagccgugacgacuagucggcacugg
caauuuuugacagucucgagacug
....................<<<..<<.......<.....>....>>.>>
>.........................<<<<<<.<<<<..>>>>.>>>.>>
>.........<<<<<<<>>>>>>>
Receptor-Ligand Complex Structure
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PDB8r08 Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution6.1 Å
Binding residue
(original residue number in PDB)		A246 C247 L251 G253 A254 Q255 P269 H270 K290 K353 R354 R357 M362
Binding residue
(residue number reindexed from 1)		A174 C175 L179 G181 A182 Q183 P187 H188 K208 K264 R265 R268 M273
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030621 U4 snRNA binding
GO:0030622 U4atac snRNA binding
GO:0030674 protein-macromolecule adaptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0070990 snRNP binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0048254 snoRNA localization
GO:0071166 ribonucleoprotein complex localization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005687 U4 snRNP
GO:0005690 U4atac snRNP
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome
GO:0071339 MLL1 complex
GO:0097526 spliceosomal tri-snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r08, PDBe:8r08, PDBj:8r08
PDBsum8r08
PubMed38778104
UniProtQ8WWY3|PRP31_HUMAN U4/U6 small nuclear ribonucleoprotein Prp31 (Gene Name=PRPF31)

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