Structure of PDB 8qxd Chain L Binding Site BS01

Receptor Information
>8qxd Chain L (length=301) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFAEIMMKIEEYISKQEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRF
PELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTAS
TTQGQQLSEEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSII
IGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQSVLPHTGYIYHSDIVQS
LPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQ
EKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQ
E
Ligand information
>8qxd Chain 4 (length=124) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcg
auuugcuaauugaaaacuucccaauagccgugacgacuagucggcacugg
caauuuuugacagucucgagacug
...................<<<<<.<<<.....<<.....>>..>>>>>>
>>........................<<<<<<.<<<<..>>>>.>>>.>>
>.........<<<<<<<>>>>>>>
Receptor-Ligand Complex Structure
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PDB8qxd Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution9.6 Å
Binding residue
(original residue number in PDB)		C247 L251 H270 A297 R354
Binding residue
(residue number reindexed from 1)		C175 L179 H188 A215 R265
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030621 U4 snRNA binding
GO:0030622 U4atac snRNA binding
GO:0030674 protein-macromolecule adaptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0070990 snRNP binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0048254 snoRNA localization
GO:0071166 ribonucleoprotein complex localization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005687 U4 snRNP
GO:0005690 U4atac snRNP
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071011 precatalytic spliceosome
GO:0071339 MLL1 complex
GO:0097526 spliceosomal tri-snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qxd, PDBe:8qxd, PDBj:8qxd
PDBsum8qxd
PubMed38778104
UniProtQ8WWY3|PRP31_HUMAN U4/U6 small nuclear ribonucleoprotein Prp31 (Gene Name=PRPF31)

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