Structure of PDB 8qu5 Chain L Binding Site BS01

Receptor Information
>8qu5 Chain L (length=115) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AIQKMTRVRVVDNSALGNSPYHRAPRCIHVYKKNGVGKVGDQILLAIKGQ
KKKALIVGHCMPGPRMTPRFDSNNVVLIEDNGNPVGTRIKTPIPTSLRKR
EGEYSKVLAIAQNFV
Ligand information
>8qu5 Chain A (length=1049) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcgccuggugauagcugguugucc
aagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaaucccc
uuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuagg
aaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaa
aagcagccaccaauuaagaaagcguucaagcucaacaccucccaaacaua
uaacugaacuccucacacccaauuggaccaaucuaucacccuauagaaga
acuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccug
cgucagaucacugacaauuaacagcccaauaucuacaaucaaccaacaag
ucauuauuacccucacugucaacccaacaggcaugcucauaaggaaaggu
uaaaaaaaguaaaaggaaacaucaccucuagcaucaccaguauuagaggc
cagcugucucuuacuuuuaaccagugaaauugaccugcccgugaggcggg
cauaacacagcaagacgagacccuauggagcuuuaauuuauuaaugcaaa
caccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaacc
uccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauuga
uccaauaacuugaccaacggaacaaguuacccuaggguaucuacuuuauu
ccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgcc
uucuaaaugauaucaucucaacuuaauacccacacccaagaacaggguu
<<<.......<<<<..................................<.
.....>...........<<.....>>.......>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<....>.>>>>......>.>>..<<<<
<<....<<<<....>>>>.<<.<<<<<<<<<<.....<<......>>...
..>>>>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>...<<<
......>>>....<<<.<<<...<..............<....<<<....
.....>>>....>.......<<<......>>>..................
....>...>>>>>>........>>>>>>...<<<<<......>>>>>...
......>>>>>><......<<..<<<....>>><<<<..<<<<.......
.<<<<<....>>>>>......<<<...<<<<...................
....>>>>.......>>>.....<<....>>.>>>>.....>>>>..<<<
<...<<<<<<<<.<<.........<<<<<<.............>>>>>>.
.......>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>
>.......<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<..
....>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>
>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.......
..<<<....>>>............>>>>..>>>>>>>..>>>.>>..<<<
.<<<.................>>>.>>><<<<<...<<<....>>>.>>>
>>.<<<.<............>.>>>........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qu5 GTPBP8 plays a role in mitoribosome formation in human mitochondria.
Resolution2.42 Å
Binding residue
(original residue number in PDB)		Q33 M35 T36 R37 R53 K62 N64 M91 P92 R95
Binding residue
(residue number reindexed from 1)		Q3 M5 T6 R7 R23 K32 N34 M61 P62 R65
Gene Ontology
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qu5, PDBe:8qu5, PDBj:8qu5
PDBsum8qu5
PubMed38969660
UniProtQ6P1L8|RM14_HUMAN Large ribosomal subunit protein uL14m (Gene Name=MRPL14)

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