Structure of PDB 8q1b Chain L Binding Site BS01

Receptor Information

>8q1b Chain L (length=443) Species: 4896 (Schizosaccharomyces pombe)

ATTALPKTETTTLKNGLTVATEHHPYAQTATVLVGVDAGSRAETAKNNGA
AHFLEHLAFKGTKNRSQKALELEFENTGAHLNAYTSREQTVYYAHAFKNA
VPNAVAVLADILTNSSISASAVERERQVILREQEEVDKMADEVVFDHLHA
TAYQGHPLGRTILGPKENIESLTREDLLQYIKDNYRSDRMIISSAGSISH
EELVKLAEKYFGHLEPSAEQLSLGAPRGLKPRFVGSEIRARDDDSPTANI
AIAVEGMSWKHPDYFTALVMQAIIGNWDRAMGASPHLSSRLSTIVQQHQL
ANSFMSFSTSYSDTGLWGIYLVTENLGRIDDLVHFTLQNWARLTVATRAE
VERAKAQLRASLLLSLDSTTAIAEDIGRQLLTTGRRMSPQEVDLRIGQIT
EKDVARVASEMIWDKDIAVSAVGSIEGLLDYNRIRSSISMNRW

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 8q1b Chain L Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8q1b Structure and function of the S. pombe III-IV-cyt c supercomplex.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): H66 H70 E146
• Binding residue (residue number reindexed from 1): H52 H56 E132
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.24.64: mitochondrial processing peptidase.

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0006627 protein processing involved in protein targeting to mitochondrion

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0017087 mitochondrial processing peptidase complex

External links

• PDB: RCSB:8q1b, PDBe:8q1b, PDBj:8q1b
• PDBsum: 8q1b
• PubMed: 37939086
• UniProt: Q9P7X1|MPPB_SCHPO Probable mitochondrial-processing peptidase subunit beta (Gene Name=qcr1)