Structure of PDB 8h1t Chain L Binding Site BS01

Receptor Information
>8h1t Chain L (length=301) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKW
IEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSSATHALLSVLLN
CSSVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHL
PETMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIM
ERIGLATAGEPYHDIRFNLMAVVPDRRIKYEAEACLKEEVEKRKKFKIDD
QRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRK
P
Ligand information
>8h1t Chain I (length=167) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccggatcccctggagaatcccggtgccgaggccgctcaattggtcgtaga
cagctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaa
ccgccaaggggattactccctagtctccaggcacgtgtcacatatataca
tcctgttccagtgccgg
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8h1t Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R699 R700 R701
Binding residue
(residue number reindexed from 1)		R285 R286 R287
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0031490 chromatin DNA binding
GO:0140950 histone H2A deubiquitinase activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0001558 regulation of cell growth
GO:0001701 in utero embryonic development
GO:0001894 tissue homeostasis
GO:0002574 thrombocyte differentiation
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008283 cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010467 gene expression
GO:0016579 protein deubiquitination
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030223 neutrophil differentiation
GO:0030851 granulocyte differentiation
GO:0033028 myeloid cell apoptotic process
GO:0035520 monoubiquitinated protein deubiquitination
GO:0035726 common myeloid progenitor cell proliferation
GO:0036211 protein modification process
GO:0036344 platelet morphogenesis
GO:0043249 erythrocyte maturation
GO:0043363 nucleate erythrocyte differentiation
GO:0045892 negative regulation of DNA-templated transcription
GO:0050727 regulation of inflammatory response
GO:0051726 regulation of cell cycle
GO:0061484 hematopoietic stem cell homeostasis
GO:0061519 macrophage homeostasis
GO:0070050 neuron cellular homeostasis
GO:0070661 leukocyte proliferation
GO:0071108 protein K48-linked deubiquitination
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1903955 positive regulation of protein targeting to mitochondrion
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0035517 PR-DUB complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8h1t, PDBe:8h1t, PDBj:8h1t
PDBsum8h1t
PubMed36991118
UniProtQ92560|BAP1_HUMAN Ubiquitin carboxyl-terminal hydrolase BAP1 (Gene Name=BAP1)

[Back to BioLiP]