Structure of PDB 8guj Chain L Binding Site BS01

Receptor Information
>8guj Chain L (length=73) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEA
RQRKCPKCNAAFGAHDFHRIYIS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8guj Chain L Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8guj Structure of the human Bre1 complex bound to the nucleosome
Resolution2.8 Å
Binding residue
(original residue number in PDB)		C963 H965 C983 C986
Binding residue
(residue number reindexed from 1)		C35 H37 C55 C58
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0003730 mRNA 3'-UTR binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006325 chromatin organization
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0045944 positive regulation of transcription by RNA polymerase II
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0033503 HULC complex
GO:0043005 neuron projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8guj, PDBe:8guj, PDBj:8guj
PDBsum8guj
PubMed38519511
UniProtO75150|BRE1B_HUMAN E3 ubiquitin-protein ligase BRE1B (Gene Name=RNF40)

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