Structure of PDB 8ftd Chain L Binding Site BS01

Receptor Information
>8ftd Chain L (length=470) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPE
AITYLLEQYDRVEAEEARLSDLITGFVPELAREKFAELRAQYVVTRDTIA
TAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVE
QCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQK
LQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKK
YTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSI
ADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDK
IRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAA
THDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAK
ALRKLRHPSRSEVLRSFLDD
Ligand information
>8ftd Chain P (length=61) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
attgaggctggtcatggcgctcataaatctggtatacttacccacattgg
ggctgattctg
Receptor-Ligand Complex Structure
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PDB8ftd General transcription factor from Escherichia coli with a distinct mechanism of action.
Resolution2.76 Å
Binding residue
(original residue number in PDB)		V98 R385 L386 K392 K418 R423 Y425 K426 T429 Y430 W433 W434 Q437 R451 H455 T583 E585 R586 Q589
Binding residue
(residue number reindexed from 1)		V9 R242 L243 K249 K275 R280 Y282 K283 T286 Y287 W290 W291 Q294 R308 H312 T440 E442 R443 Q446
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ftd, PDBe:8ftd, PDBj:8ftd
PDBsum8ftd
PubMed38177674
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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