Structure of PDB 8cgj Chain L Binding Site BS01

Receptor Information
>8cgj Chain L (length=114) Species: 679895 (Escherichia coli BW25113) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATVNQLVRKPRNVPALEACPQKRGVCTRVYTTTPKKPNSALRKVCRVRLT
NGFEVTSYIGGEGHNLQEHSVILIRGGRVKDLPGVRYHTVRGALDCSGVK
DRKQARSKYGVKRP
Ligand information
>8cgj Chain A (length=1130) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaa
cacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacga
guggcggacgggugaguaaugucugggaaacugccugauggagggggaua
acuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagg
gcucuugccaucggaugugcccagaugggauuagcuaguaggugggguaa
cggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagcca
cacuggaacugagacacgguccagacuccuacgggaggcagcagugggga
auauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaag
aagcccuucggguuguaaaguacuuucagcggggaggaagggaguaaagu
uaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuc
cgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauua
cugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccc
cgggcucaaccugggaacugcaucugauacuggcaagcuugagucucgua
gagggggguagaauuccagguguagcggugaaaugcguagagaucuggag
gaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggug
cgaaagcguggggagcaaacaggauuagauacccugguaguccacgccgu
aaacgaugucgacuuggagguugugcgcguggcuuccggagcuaacgcgu
uaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaau
ugacgggggcccgcagucgucagcucguguugugaaauguuggguuaagu
cccgcaacgagcgcaacaugacgucaacccgggccuuguacacaccgccc
gucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgg
gagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaag
guaaccguaggggaaccugcgguuggauca
.......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....
<<<.<<<..<<<..<<.<<..<<<<<<..<.......>.>>>.>>>>>..
>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....
.<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<
..>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.....
....>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>
>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>....
.....<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<....
....<<....>>.......>>>>...<.<<<<<......<.<<<<<<<<.
......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<
<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......
...<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<
<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<.
..<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>
...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>
>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>...
.......<<<<<<.<<<<<<<<<<<..>>>>>>>>>>>..<<..))>>..
...>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]
<<<<<.<<<<<<<.........<<<<<<<<<....>>>..<<<<......
>>>>..>>>>>>.................>>>>>>>>>>.>>....<..<
<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>
>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>...
..<<<<<<<<<....>>>>>>>>>......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cgj Structural conservation of antibiotic interaction with ribosomes.
Resolution1.79 Å
Binding residue
(original residue number in PDB)
A2 N5 Q6 L7 R9 R12 V21 A26 C27 P28 Q29 K30 R31 K43 K44 N46 S47 A48 R50 K51 T58 Y66 G68 G69 E70 L81 R83 G84 R86 K88 X89 P91 R94 R110 K111 Q112 A113 R114 S115 K116 V119 K120 R121
Binding residue
(residue number reindexed from 1)
A1 N4 Q5 L6 R8 R11 V13 A18 C19 P20 Q21 K22 R23 K35 K36 N38 S39 A40 R42 K43 T50 Y58 G60 G61 E62 L73 R75 G76 R78 K80 X81 P83 R86 R102 K103 Q104 A105 R106 S107 K108 V111 K112 R113
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0034336 misfolded RNA binding
Biological Process
GO:0000372 Group I intron splicing
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0033120 positive regulation of RNA splicing
GO:0034337 RNA folding
GO:0046677 response to antibiotic
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8cgj, PDBe:8cgj, PDBj:8cgj
PDBsum8cgj
PubMed37550453
UniProtP0A7S3|RS12_ECOLI Small ribosomal subunit protein uS12 (Gene Name=rpsL)

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