Structure of PDB 8c6j Chain L Binding Site BS01
Receptor Information
>8c6j Chain L (length=144) Species:
9606
(Homo sapiens) [
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MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIF
RIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENL
CCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG
Ligand information
>8c6j Chain 6 (length=97) [
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gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaaga
uuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu
<<<<<.<<....>>>>>>>...............................
......<<...<<<.....>>>....>>...................
Receptor-Ligand Complex Structure
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PDB
8c6j
Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins.
Resolution
2.8 Å
Binding residue
(original residue number in PDB)
G39 K40 R41 K42 Q95 G96 E98 T111 N112 T115 N116 C117 I118 R120 V121 P122 L126 C134 T135 S143 G144
Binding residue
(residue number reindexed from 1)
G39 K40 R41 K42 Q95 G96 E98 T111 N112 T115 N116 C117 I118 R120 V121 P122 L126 C134 T135 S143 G144
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0005515
protein binding
GO:0016922
nuclear receptor binding
GO:0030374
nuclear receptor coactivator activity
Biological Process
GO:0000398
mRNA splicing, via spliceosome
GO:0006397
mRNA processing
GO:0008380
RNA splicing
GO:0045893
positive regulation of DNA-templated transcription
GO:2000825
positive regulation of androgen receptor activity
Cellular Component
GO:0000785
chromatin
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005681
spliceosomal complex
GO:0071007
U2-type catalytic step 2 spliceosome
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Cellular Component
External links
PDB
RCSB:8c6j
,
PDBe:8c6j
,
PDBj:8c6j
PDBsum
8c6j
PubMed
36867703
UniProt
P41223
|BUD31_HUMAN Protein BUD31 homolog (Gene Name=BUD31)
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