Structure of PDB 7yxu Chain L Binding Site BS01

Receptor Information

>7yxu Chain L (length=213) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYA
ASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYDNLPTFGQ
GTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKV
DNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG
LSSPVTKSFNRGE

Ligand information

Ligand ID

TMO

InChI

InChI=1S/C3H9NO/c1-4(2,3)5/h1-3H3

InChIKey

UYPYRKYUKCHHIB-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.370 OpenEye OEToolkits 1.7.0	C[N+](C)(C)[O-]
ACDLabs 12.01	[O-][N+](C)(C)C

Formula

C3 H9 N O

Name

trimethylamine oxide

PDB chain

7yxu Chain H Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7yxu The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies.
Resolution	2.31 Å
Binding residue (original residue number in PDB)	P40 G41
Binding residue (residue number reindexed from 1)	P40 G41
Annotation score	1

External links

PDB	RCSB:7yxu, PDBe:7yxu, PDBj:7yxu
PDBsum	7yxu
PubMed	36343381

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